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Article: Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity

TitleInhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity
Authors
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.asp
Citation
Free Radical Research, 2012, v. 46 n. 9, p. 1123-1129 How to Cite?
AbstractOur recent study has indicated that Chinese green tea (Lung Chen), in which epigallocatechin-3-gallate (EGCG) accounts for 60% of catechins, protected cigarette smoke-induced lung injury. We now hypothesized that Lung Chen tea may also have potential effect on lung oxidative stress and proteases/anti-proteases in a smoking rat model. Sprague–Dawley rats were exposed to either sham air (SA) or 4% cigarette smoke (CS) plus 2% Lung Chen tea or water by oral gavage. Serine proteases, matrix metalloproteinases (MMPs) and their respective endogenous inhibitors were determined in bronchoalveolar lavage (BAL) and lung tissues by gelatin/casein zymography and biochemical assays. Green tea consumption significantly decreased CS-induced elevation of lung lipid peroxidation marker, malondialdehyde (MDA), and CS-induced up-regulation of neutrophil elastase (NE) concentration and activity along with that of α1-antitrypsin (α1-AT) and secretory leukoproteinase inhibitor (SLPI) in BAL and lung. In parallel, significant elevation of MMP-12 activity was found in BAL and lung of the CS-exposed group, which returned to the levels of SA-exposed group after green tea consumption but not CS-induced reduction of tissue inhibitor of metalloproteinase (TIMP)-1 activity, which was not reversed by green tea consumption. Taken together, our data supported the presence of local oxidative stress and protease/anti-protease imbalance in the airways after CS exposure, which might be alleviated by green tea consumption through its biological antioxidant activity. Read More: http://informahealthcare.com/doi/abs/10.3109/10715762.2012.692786
Persistent Identifierhttp://hdl.handle.net/10722/159279
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_US
dc.contributor.authorChan, CHen_US
dc.contributor.authorYeung, SCen_US
dc.contributor.authorMan, RYKen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorMak, JCWen_US
dc.date.accessioned2012-08-16T05:47:55Z-
dc.date.available2012-08-16T05:47:55Z-
dc.date.issued2012en_US
dc.identifier.citationFree Radical Research, 2012, v. 46 n. 9, p. 1123-1129en_US
dc.identifier.urihttp://hdl.handle.net/10722/159279-
dc.description.abstractOur recent study has indicated that Chinese green tea (Lung Chen), in which epigallocatechin-3-gallate (EGCG) accounts for 60% of catechins, protected cigarette smoke-induced lung injury. We now hypothesized that Lung Chen tea may also have potential effect on lung oxidative stress and proteases/anti-proteases in a smoking rat model. Sprague–Dawley rats were exposed to either sham air (SA) or 4% cigarette smoke (CS) plus 2% Lung Chen tea or water by oral gavage. Serine proteases, matrix metalloproteinases (MMPs) and their respective endogenous inhibitors were determined in bronchoalveolar lavage (BAL) and lung tissues by gelatin/casein zymography and biochemical assays. Green tea consumption significantly decreased CS-induced elevation of lung lipid peroxidation marker, malondialdehyde (MDA), and CS-induced up-regulation of neutrophil elastase (NE) concentration and activity along with that of α1-antitrypsin (α1-AT) and secretory leukoproteinase inhibitor (SLPI) in BAL and lung. In parallel, significant elevation of MMP-12 activity was found in BAL and lung of the CS-exposed group, which returned to the levels of SA-exposed group after green tea consumption but not CS-induced reduction of tissue inhibitor of metalloproteinase (TIMP)-1 activity, which was not reversed by green tea consumption. Taken together, our data supported the presence of local oxidative stress and protease/anti-protease imbalance in the airways after CS exposure, which might be alleviated by green tea consumption through its biological antioxidant activity. Read More: http://informahealthcare.com/doi/abs/10.3109/10715762.2012.692786-
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.asp-
dc.relation.ispartofFree Radical Researchen_US
dc.rightsFree Radical Research. Copyright © Informa Healthcare-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleInhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activityen_US
dc.typeArticleen_US
dc.identifier.emailChan, CH: bcsty99@hkucc.hku.hken_US
dc.identifier.emailYeung, SC: flag@hkucc.hku.hken_US
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_US
dc.identifier.emailIp, MSM: msmip@hku.hken_US
dc.identifier.emailMak, JCW: judymak@hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturepostprint-
dc.identifier.doi10.3109/10715762.2012.692786-
dc.identifier.pmid22574903-
dc.identifier.hkuros204335en_US
dc.identifier.hkuros223637-
dc.identifier.spage1123en_US
dc.identifier.epage1129en_US
dc.identifier.isiWOS:000307067900009-

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