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Article: A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection

TitleA functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2012, v. 206 n. 4, p. 495-503 How to Cite?
AbstractInfection due to 2009 pandemic H1N1 influenza A virus (A[H1N1]pdm09) is commonly manifested as mild infection but occasionally as severe pneumonia. We hypothesized that host genetic variations may contribute to disease severity. An initially small-scale genome-wide association study guided the selection of CD55 single-nucleotide polymorphisms in 425 Chinese patients with severe (n = 177) or mild (n = 248) disease. Carriers of rs2564978 genotype T/T were significantly associated with severe infection (odds ratio, 1.75; P = .011) under a recessive model, after adjustment for clinical confounders. An allele-specific effect on CD55 expression was revealed and ascribed to a promoter indel variation, which was in complete linkage disequilibrium with rs2564978. The promoter variant with deletion exhibited significantly lower transcriptional activity. We further demonstrated that CD55 can protect respiratory epithelial cells from complement attack. Additionally, A(H1N1)pdm09 infection promoted CD55 expression. In conclusion, CD55 polymorphisms are associated with severe A(H1N1)pdm09 infection. CD55 may exert a substantial impact on the disease severity of A(H1N1)pdm09 infection.
Persistent Identifierhttp://hdl.handle.net/10722/159276
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Jen_US
dc.contributor.authorTo, KKWen_US
dc.contributor.authorDong, Hen_US
dc.contributor.authorCheng, ZSen_US
dc.contributor.authorLau, CCYen_US
dc.contributor.authorPoon, KMen_US
dc.contributor.authorFan, YHen_US
dc.contributor.authorSong, YQen_US
dc.contributor.authorTse, Hen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorZheng, BJen_US
dc.contributor.authorZhao, GPen_US
dc.contributor.authorYuen, KY-
dc.date.accessioned2012-08-16T05:47:53Z-
dc.date.available2012-08-16T05:47:53Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Infectious Diseases, 2012, v. 206 n. 4, p. 495-503en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/159276-
dc.description.abstractInfection due to 2009 pandemic H1N1 influenza A virus (A[H1N1]pdm09) is commonly manifested as mild infection but occasionally as severe pneumonia. We hypothesized that host genetic variations may contribute to disease severity. An initially small-scale genome-wide association study guided the selection of CD55 single-nucleotide polymorphisms in 425 Chinese patients with severe (n = 177) or mild (n = 248) disease. Carriers of rs2564978 genotype T/T were significantly associated with severe infection (odds ratio, 1.75; P = .011) under a recessive model, after adjustment for clinical confounders. An allele-specific effect on CD55 expression was revealed and ascribed to a promoter indel variation, which was in complete linkage disequilibrium with rs2564978. The promoter variant with deletion exhibited significantly lower transcriptional activity. We further demonstrated that CD55 can protect respiratory epithelial cells from complement attack. Additionally, A(H1N1)pdm09 infection promoted CD55 expression. In conclusion, CD55 polymorphisms are associated with severe A(H1N1)pdm09 infection. CD55 may exert a substantial impact on the disease severity of A(H1N1)pdm09 infection.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/en_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAntigens, CD55 - genetics - immunology-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunology - pathogenicity-
dc.subject.meshInfluenza, Human - genetics - immunology - pathology - virology-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleA functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infectionen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=&spage=&epage=&date=2012&atitle=A+functional+variation+in+CD55+increases+the+severity+of+2009+pandemic+H1N1+influenza+A+virus+infectionen_US
dc.identifier.emailZhou, J: jiezhou@hku.hken_US
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hken_US
dc.identifier.emailLau, CCY: candylau@graduate.hku.hken_US
dc.identifier.emailPoon, KM: vincent.poonkm@gmail.comen_US
dc.identifier.emailSong, YQ: songy@hku.hken_US
dc.identifier.emailTse, H: herman@graduate.hku.hken_US
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hken_US
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hken_US
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityZhou, J=rp01412en_US
dc.identifier.authorityTo, KKW=rp01384en_US
dc.identifier.authoritySong, Y=rp00488en_US
dc.identifier.authorityTse, H=rp00519en_US
dc.identifier.authorityZheng, B=rp00353en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/infdis/jis378-
dc.identifier.pmid22693232-
dc.identifier.scopuseid_2-s2.0-84866927784-
dc.identifier.hkuros202166en_US
dc.identifier.volume206-
dc.identifier.issue4-
dc.identifier.spage495-
dc.identifier.epage503-
dc.identifier.isiWOS:000306667000007-
dc.publisher.placeUnited States-

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