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Article: LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
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TitleLTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
 
AuthorsChen, H4
Ko, JMY2
Wong, VCL2
Hyytiainen, M10
KeskiOja, J10
Chua, D2 7
Nicholls, JM2
Cheung, FMF2 3
Lee, AWM2 3
Kwong, DLW2
Chiu, PM2
Zabarovsky, ER8 6 1
Tsao, SW2
Tao, Q9
Kan, R2
Chan, SHK2
Stanbridge, EJ5
Lung, ML2
 
KeywordsAnti-angiogenesis
Latent transforming growth factor β binding protein 2 (LTBP-2)
Metastatic growth
Nasopharyngeal carcinoma (NPC)
Tumor cell dormancy
Tumor suppression
 
Issue Date2012
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
CitationCancer Letters, 2012, v. 325 n. 1, p. 89-98 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2012.06.005
 
AbstractThis study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment. © 2012 Elsevier Ireland Ltd.
 
ISSN0304-3835
2013 Impact Factor: 5.016
 
DOIhttp://dx.doi.org/10.1016/j.canlet.2012.06.005
 
ISI Accession Number IDWOS:000308781600011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, H
 
dc.contributor.authorKo, JMY
 
dc.contributor.authorWong, VCL
 
dc.contributor.authorHyytiainen, M
 
dc.contributor.authorKeskiOja, J
 
dc.contributor.authorChua, D
 
dc.contributor.authorNicholls, JM
 
dc.contributor.authorCheung, FMF
 
dc.contributor.authorLee, AWM
 
dc.contributor.authorKwong, DLW
 
dc.contributor.authorChiu, PM
 
dc.contributor.authorZabarovsky, ER
 
dc.contributor.authorTsao, SW
 
dc.contributor.authorTao, Q
 
dc.contributor.authorKan, R
 
dc.contributor.authorChan, SHK
 
dc.contributor.authorStanbridge, EJ
 
dc.contributor.authorLung, ML
 
dc.date.accessioned2012-08-16T05:47:33Z
 
dc.date.available2012-08-16T05:47:33Z
 
dc.date.issued2012
 
dc.description.abstractThis study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment. © 2012 Elsevier Ireland Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCancer Letters, 2012, v. 325 n. 1, p. 89-98 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2012.06.005
 
dc.identifier.citeulike11279395
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2012.06.005
 
dc.identifier.epage98
 
dc.identifier.hkuros202596
 
dc.identifier.isiWOS:000308781600011
 
dc.identifier.issn0304-3835
2013 Impact Factor: 5.016
 
dc.identifier.issue1
 
dc.identifier.pmid22743615
 
dc.identifier.scopuseid_2-s2.0-84865283257
 
dc.identifier.spage89
 
dc.identifier.urihttp://hdl.handle.net/10722/159266
 
dc.identifier.volume325
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
dc.publisher.placeIreland
 
dc.relation.ispartofCancer Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAnti-angiogenesis
 
dc.subjectLatent transforming growth factor β binding protein 2 (LTBP-2)
 
dc.subjectMetastatic growth
 
dc.subjectNasopharyngeal carcinoma (NPC)
 
dc.subjectTumor cell dormancy
 
dc.subjectTumor suppression
 
dc.titleLTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
 
dc.typeArticle
 
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<contributor.author>Lee, AWM</contributor.author>
<contributor.author>Kwong, DLW</contributor.author>
<contributor.author>Chiu, PM</contributor.author>
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Author Affiliations
  1. Linköpings universitet
  2. The University of Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. Hong Kong University of Science and Technology
  5. UC Irvine
  6. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
  7. Hong Kong Sanatorium and Hospital
  8. Södersjukhuset
  9. Chinese University of Hong Kong
  10. Helsinki University Central Hospital