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Article: The estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation

TitleThe estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulation
Authors
KeywordsAngiotensin II
Estrogen related receptor alpha
Animal experiment
Brain region
Gene expression
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2012, v. 7 n. 6 How to Cite?
AbstractOsmoregulation via maintenance of water and salt homeostasis is a vital process. In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release. In this report, we provide evidence that estrogen-related receptor α (ERRα, NR3B1), a transcription factor mainly involved in metabolism, acts as an upstream activator of the SCT gene. In vitro studies using mouse hypothalamic cell line N-42 show that ERRα upregulates SCT promoter and gene expression. More importantly, knockdown of endogenous ERRα abolishes SCT promoter activation in response to hypertonic and ANGII stimulations. In mouse brain, ERRα coexpresses with SCT in various osmoregulatory brain regions, including the lamina terminalis and the paraventricular nucleus of the hypothalamus, and its expression is induced by hyperosmotic and ANGII treatments. Based on our data, we propose that both the upregulation of ERRα and/or the increased binding of ERRα to the mouse SCT promoter are two possible mechanisms for the elevated SCT expression upon hyperosmolality and central ANGII stimulation. © 2012 Lee et al.
Persistent Identifierhttp://hdl.handle.net/10722/159264
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, VHYen_HK
dc.contributor.authorLam, IPYen_HK
dc.contributor.authorChoi, HSen_HK
dc.contributor.authorChow, BKCen_HK
dc.contributor.authorLee, LTOen_HK
dc.date.accessioned2012-08-16T05:47:32Z-
dc.date.available2012-08-16T05:47:32Z-
dc.date.issued2012en_HK
dc.identifier.citationPlos One, 2012, v. 7 n. 6en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159264-
dc.description.abstractOsmoregulation via maintenance of water and salt homeostasis is a vital process. In the brain, a functional secretin (SCT) and secretin receptor (SCTR) axis has recently been shown to mediate central actions of angiotensin II (ANGII), including initiation of water intake and stimulation of vasopressin (VP) expression and release. In this report, we provide evidence that estrogen-related receptor α (ERRα, NR3B1), a transcription factor mainly involved in metabolism, acts as an upstream activator of the SCT gene. In vitro studies using mouse hypothalamic cell line N-42 show that ERRα upregulates SCT promoter and gene expression. More importantly, knockdown of endogenous ERRα abolishes SCT promoter activation in response to hypertonic and ANGII stimulations. In mouse brain, ERRα coexpresses with SCT in various osmoregulatory brain regions, including the lamina terminalis and the paraventricular nucleus of the hypothalamus, and its expression is induced by hyperosmotic and ANGII treatments. Based on our data, we propose that both the upregulation of ERRα and/or the increased binding of ERRα to the mouse SCT promoter are two possible mechanisms for the elevated SCT expression upon hyperosmolality and central ANGII stimulation. © 2012 Lee et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAngiotensin II-
dc.subjectEstrogen related receptor alpha-
dc.subjectAnimal experiment-
dc.subjectBrain region-
dc.subjectGene expression-
dc.titleThe estrogen-related receptor alpha upregulates secretin expressions in response to hypertonicity and angiotensin II stimulationen_HK
dc.typeArticleen_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0039913en_HK
dc.identifier.pmid22761926-
dc.identifier.pmcidPMC3382582-
dc.identifier.scopuseid_2-s2.0-84862705506en_HK
dc.identifier.hkuros202443en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862705506&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue6en_HK
dc.identifier.eissn1932-6203-
dc.identifier.isiWOS:000305781700072-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, VHY=14050662700en_HK
dc.identifier.scopusauthoridLam, IPY=14050702700en_HK
dc.identifier.scopusauthoridChoi, HS=7404338771en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK

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