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Article: Possible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy

TitlePossible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancy
Authors
Issue Date2012
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2012, v. 97 n. 6, p. 2105-2112 How to Cite?
AbstractContext: Tubal ectopic pregnancy (tEP) is currently the leading cause of pregnancy-related deaths during the first trimester. Our current knowledge on the molecular pathogenesis is limited. Objective: The objective of the study was to find out the possible role of adrenomedullin (ADM) in the pathogenesis of tEP. Design: This was an experimental in vitro study on oviductal tissue. Setting: The study was conducted at a university teaching hospital. Patients and Interventions: Patients included those having oviducts removed surgically during salpingectomy for tEP or hysterectomy for benign gynecological conditions. Oviductal tissues were incubated in hormonal condition mimicking early pregnancy before used for in vitro experiments. Main Outcome Measures: Plasma ADM concentration, oviductal expression of ADM and its receptors, ciliary beat frequency, smooth muscle contraction were measured. Results: The ciliary beat frequency and frequency of muscle contraction were lower in the oviducts from patients with tEP than those from simulated normal pregnancy. The plasma and oviductal tissue ADM levels were also lower. The decreases in ciliary beat and frequency of contraction were restored to normal after ADM treatment. Conclusions: The results suggest that the lower ADM level in the oviducts of tEP may lead to the decrease in ciliary beating and muscle contraction, with the result that the embryo is retained and implanted in the oviduct. Our findings explain for the first time the etiology of tubal pregnancy on the basis of an impairment of the transport of the fertilized ovum resulting from an ADM deficiency and raise the possibility of using the plasma ADM level as a predictor for tubal ectopic pregnancy. Copyright © 2012 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/159263
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiao, SBen_HK
dc.contributor.authorLi, HWRen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorTang, Fen_HK
dc.contributor.authorO, WSen_HK
dc.date.accessioned2012-08-16T05:47:32Z-
dc.date.available2012-08-16T05:47:32Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2012, v. 97 n. 6, p. 2105-2112en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/159263-
dc.description.abstractContext: Tubal ectopic pregnancy (tEP) is currently the leading cause of pregnancy-related deaths during the first trimester. Our current knowledge on the molecular pathogenesis is limited. Objective: The objective of the study was to find out the possible role of adrenomedullin (ADM) in the pathogenesis of tEP. Design: This was an experimental in vitro study on oviductal tissue. Setting: The study was conducted at a university teaching hospital. Patients and Interventions: Patients included those having oviducts removed surgically during salpingectomy for tEP or hysterectomy for benign gynecological conditions. Oviductal tissues were incubated in hormonal condition mimicking early pregnancy before used for in vitro experiments. Main Outcome Measures: Plasma ADM concentration, oviductal expression of ADM and its receptors, ciliary beat frequency, smooth muscle contraction were measured. Results: The ciliary beat frequency and frequency of muscle contraction were lower in the oviducts from patients with tEP than those from simulated normal pregnancy. The plasma and oviductal tissue ADM levels were also lower. The decreases in ciliary beat and frequency of contraction were restored to normal after ADM treatment. Conclusions: The results suggest that the lower ADM level in the oviducts of tEP may lead to the decrease in ciliary beating and muscle contraction, with the result that the embryo is retained and implanted in the oviduct. Our findings explain for the first time the etiology of tubal pregnancy on the basis of an impairment of the transport of the fertilized ovum resulting from an ADM deficiency and raise the possibility of using the plasma ADM level as a predictor for tubal ectopic pregnancy. Copyright © 2012 by The Endocrine Society.en_HK
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.subject.meshAdrenomedullin - blood - genetics - physiology-
dc.subject.meshBiological Markers - blood-
dc.subject.meshCilia - physiology-
dc.subject.meshFallopian Tubes - physiology-
dc.subject.meshPregnancy, Tubal - blood - etiology - physiopathology-
dc.titlePossible role of adrenomedullin in the pathogenesis of tubal ectopic pregnancyen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, HWR: raymondli@hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_HK
dc.identifier.authorityLi, HWR=rp01649en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityO, WS=rp00315en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/jc.2011-3290en_HK
dc.identifier.pmid22456622-
dc.identifier.scopuseid_2-s2.0-84861987864en_HK
dc.identifier.hkuros202276en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861987864&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume97en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2105en_HK
dc.identifier.epage2112en_HK
dc.identifier.eissn1945-7197-
dc.identifier.isiWOS:000306100800064-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiao, SB=36170881600en_HK
dc.identifier.scopusauthoridLi, HWR=8554164300en_HK
dc.identifier.scopusauthoridHo, JC=37761650300en_HK
dc.identifier.scopusauthoridYeung, WSB=54899819600en_HK
dc.identifier.scopusauthoridNg, EHY=54942496400en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridTang, F=54947857500en_HK
dc.identifier.scopusauthoridO, WS=6701729369en_HK

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