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Article: Prevalence of survivor bias in observational studies on fresh frozen plasma: erythrocyte ratios in trauma requiring massive transfusion

TitlePrevalence of survivor bias in observational studies on fresh frozen plasma: erythrocyte ratios in trauma requiring massive transfusion
Authors
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.org
Citation
Anesthesiology, 2012, v. 116 n. 3, p. 716-728 How to Cite?
AbstractObservational studies on transfusion in trauma comparing high versus low plasma:erythrocyte ratio were prone to survivor bias because plasma administration typically started later than erythrocytes. Therefore, early deaths were categorized in the low plasma:erythrocyte group, whereas early survivors had a higher chance of receiving a higher ratio. When early deaths were excluded, however, a bias against higher ratio can be created. Survivor bias could be reduced by performing before-and-after studies or treating the plasma:erythrocyte ratio as a time-dependent covariate.We reviewed 26 studies on blood ratios in trauma. Fifteen of the studies were survivor bias-unlikely or biased against higher ratio; among them, 10 showed an association between higher ratio and improved survival, and five did not. Eleven studies that were judged survivor bias-prone favoring higher ratio suggested that a higher ratio was superior.Without randomized controlled trials controlling for survivor bias, the current available evidence supporting higher plasma:erythrocyte resuscitation is inconclusive.
Persistent Identifierhttp://hdl.handle.net/10722/159250
ISSN
2015 Impact Factor: 5.264
2015 SCImago Journal Rankings: 2.162
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, AMHen_US
dc.contributor.authorDion, PWen_US
dc.contributor.authorYeung, JHHen_US
dc.contributor.authorHolcomb, JBen_US
dc.contributor.authorCritchley, LAHen_US
dc.contributor.authorNg, CSHen_US
dc.contributor.authorKarmakar, MKen_US
dc.contributor.authorCheung, CW-
dc.contributor.authorRainer, TH-
dc.date.accessioned2012-08-16T05:47:11Z-
dc.date.available2012-08-16T05:47:11Z-
dc.date.issued2012en_US
dc.identifier.citationAnesthesiology, 2012, v. 116 n. 3, p. 716-728en_US
dc.identifier.issn0003-3022-
dc.identifier.urihttp://hdl.handle.net/10722/159250-
dc.description.abstractObservational studies on transfusion in trauma comparing high versus low plasma:erythrocyte ratio were prone to survivor bias because plasma administration typically started later than erythrocytes. Therefore, early deaths were categorized in the low plasma:erythrocyte group, whereas early survivors had a higher chance of receiving a higher ratio. When early deaths were excluded, however, a bias against higher ratio can be created. Survivor bias could be reduced by performing before-and-after studies or treating the plasma:erythrocyte ratio as a time-dependent covariate.We reviewed 26 studies on blood ratios in trauma. Fifteen of the studies were survivor bias-unlikely or biased against higher ratio; among them, 10 showed an association between higher ratio and improved survival, and five did not. Eleven studies that were judged survivor bias-prone favoring higher ratio suggested that a higher ratio was superior.Without randomized controlled trials controlling for survivor bias, the current available evidence supporting higher plasma:erythrocyte resuscitation is inconclusive.-
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.org-
dc.relation.ispartofAnesthesiologyen_US
dc.subject.meshBias (Epidemiology)-
dc.subject.meshErythrocyte Transfusion - trends-
dc.subject.meshPlasma-
dc.subject.meshShock, Hemorrhagic - epidemiology - therapy-
dc.subject.meshSurvivors-
dc.titlePrevalence of survivor bias in observational studies on fresh frozen plasma: erythrocyte ratios in trauma requiring massive transfusionen_US
dc.typeArticleen_US
dc.identifier.emailHo, AMH: hoamh@hotmail.comen_US
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.authorityCheung, CW=rp00244en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/ALN.0b013e318245c47b-
dc.identifier.pmid22270506-
dc.identifier.scopuseid_2-s2.0-84859078843-
dc.identifier.hkuros204258en_US
dc.identifier.volume116en_US
dc.identifier.issue3en_US
dc.identifier.spage716en_US
dc.identifier.epage728en_US
dc.identifier.isiWOS:000300766700031-
dc.publisher.placeUnited States-
dc.identifier.f100013994956-

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