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Article: Expression of MMP-1 and TIMP-1 in irradiated mandibles during distraction osteogenesis

TitleExpression of MMP-1 and TIMP-1 in irradiated mandibles during distraction osteogenesis
Authors
Issue Date2012
Citation
Oral Surgery, Oral Medicine, Oral Pathology And Oral Radiology, 2012, v. 114 n. 6, p. 698-703 How to Cite?
AbstractObjectives: The study aimed to evaluate the expression of MMP-1 and TIMP-1 in irradiated mandibles during distraction osteogenesis. Study Design: Rabbits in the experimental group received preoperative radiation of 9 Gy for 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at days 7, 12, 18, and 25. Specimens were subjected to immunohistochemical examination and real-time polymerase chain reaction analysis. Results: At day 7, expression of MMP-1 and TIMP-1 was significantly suppressed in the radiotherapy group in contrast to the control group. At day 12, expression of MMP-1 was significantly higher in the control group. At day 18, expression of MMP-1 and TIMP-1 was significantly higher in the control than in the radiotherapy group. Conclusions: Radiotherapy changes the expression pattern of MMP-1 and TIMP-1. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/159229
ISSN
2015 Impact Factor: 1.262
2015 SCImago Journal Rankings: 0.666
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, WBen_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorChua, DTTen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2012-08-16T05:46:50Z-
dc.date.available2012-08-16T05:46:50Z-
dc.date.issued2012en_HK
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology And Oral Radiology, 2012, v. 114 n. 6, p. 698-703en_HK
dc.identifier.issn2212-4403en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159229-
dc.description.abstractObjectives: The study aimed to evaluate the expression of MMP-1 and TIMP-1 in irradiated mandibles during distraction osteogenesis. Study Design: Rabbits in the experimental group received preoperative radiation of 9 Gy for 5 fractions. After 1 month, all rabbits underwent osteotomy and distraction osteogenesis with 7 days of latency. Three rabbits in the control and experimental groups were killed at days 7, 12, 18, and 25. Specimens were subjected to immunohistochemical examination and real-time polymerase chain reaction analysis. Results: At day 7, expression of MMP-1 and TIMP-1 was significantly suppressed in the radiotherapy group in contrast to the control group. At day 12, expression of MMP-1 was significantly higher in the control group. At day 18, expression of MMP-1 and TIMP-1 was significantly higher in the control than in the radiotherapy group. Conclusions: Radiotherapy changes the expression pattern of MMP-1 and TIMP-1. © 2012 Elsevier Inc.en_HK
dc.languageengen_US
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyen_HK
dc.titleExpression of MMP-1 and TIMP-1 in irradiated mandibles during distraction osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, LW: lwzheng@hku.hken_HK
dc.identifier.emailChua, DTT: dttchua@hkucc.hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityChua, DTT=rp00415en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.oooo.2012.01.041en_HK
dc.identifier.pmid22901654-
dc.identifier.scopuseid_2-s2.0-84869492452en_HK
dc.identifier.hkuros204625en_US
dc.identifier.hkuros226155-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84869492452&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue6en_HK
dc.identifier.spage698en_HK
dc.identifier.epage703en_HK
dc.identifier.isiWOS:000311370000017-
dc.identifier.scopusauthoridZhang, WB=37022069200en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridChua, DTT=7006773480en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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