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Article: Randomized trial on fluorides and sealants for fissure caries prevention

TitleRandomized trial on fluorides and sealants for fissure caries prevention
Authors
Issue Date2012
PublisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal of Dental Research, 2012, v. 91 n. 8, p. 753-758 How to Cite?
AbstractTo investigate the effectiveness of topical fluorides in preventing fissure caries, we conducted a randomized controlled trial with parallel groups. In total, 501 children (1,539 molars, 3,078 sites), mean age 9.1 years, who had at least one sound permanent first molar with deep fissures or fissures with signs of early caries were recruited. They were randomly allocated among four groups: (1) resin sealant, single placement; (2) 5% NaF varnish, semi-annual application; (3) 38% silver diamine fluoride (SDF) solution, annual application; and (4) placebo control. Follow-up examinations were conducted every 6 months by a masked examiner. After 24 months, 485 children (97%) were examined. Proportions of pit/fissure sites with dentin caries in the sealant, NaF, SDF, and control groups were 1.6%, 2.4%, 2.2%, and 4.6%, respectively. A multi-level logistic regression analysis accounting for the effects of data clustering and confounding factors showed that fissures in any of the three treatment groups had significantly lower risks of carious cavity development into dentin than did controls (p < 0.05). We concluded that placement of resin sealant, semi-annual application of NaF varnish, and annual application of SDF solution are all effective in preventing pit and fissure caries in permanent molars (ClinicalTrials.gov number CT01446107).
Persistent Identifierhttp://hdl.handle.net/10722/159214
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, BYen_US
dc.contributor.authorLo, ECMen_US
dc.contributor.authorChu, CHen_US
dc.contributor.authorLin, HCen_US
dc.date.accessioned2012-08-16T05:46:46Z-
dc.date.available2012-08-16T05:46:46Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Dental Research, 2012, v. 91 n. 8, p. 753-758en_US
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/159214-
dc.description.abstractTo investigate the effectiveness of topical fluorides in preventing fissure caries, we conducted a randomized controlled trial with parallel groups. In total, 501 children (1,539 molars, 3,078 sites), mean age 9.1 years, who had at least one sound permanent first molar with deep fissures or fissures with signs of early caries were recruited. They were randomly allocated among four groups: (1) resin sealant, single placement; (2) 5% NaF varnish, semi-annual application; (3) 38% silver diamine fluoride (SDF) solution, annual application; and (4) placebo control. Follow-up examinations were conducted every 6 months by a masked examiner. After 24 months, 485 children (97%) were examined. Proportions of pit/fissure sites with dentin caries in the sealant, NaF, SDF, and control groups were 1.6%, 2.4%, 2.2%, and 4.6%, respectively. A multi-level logistic regression analysis accounting for the effects of data clustering and confounding factors showed that fissures in any of the three treatment groups had significantly lower risks of carious cavity development into dentin than did controls (p < 0.05). We concluded that placement of resin sealant, semi-annual application of NaF varnish, and annual application of SDF solution are all effective in preventing pit and fissure caries in permanent molars (ClinicalTrials.gov number CT01446107).-
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925-
dc.relation.ispartofJournal of Dental Researchen_US
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAcid Etching, Dental - methods-
dc.subject.meshCariostatic Agents - therapeutic use-
dc.subject.meshDental Caries - pathology - prevention and control-
dc.subject.meshFluorides, Topical - therapeutic use-
dc.subject.meshPit and Fissure Sealants - therapeutic use-
dc.titleRandomized trial on fluorides and sealants for fissure caries preventionen_US
dc.typeArticleen_US
dc.identifier.emailLiu, BY: smilelby@hku.hken_US
dc.identifier.emailLo, ECM: hrdplcm@hkucc.hku.hken_US
dc.identifier.emailChu, CH: chchu@hku.hken_US
dc.identifier.authorityLo, ECM=rp00015en_US
dc.identifier.authorityChu, CH=rp00022en_US
dc.description.naturepostprint-
dc.identifier.doi10.1177/0022034512452278-
dc.identifier.pmid22736448-
dc.identifier.scopuseid_2-s2.0-84864119372-
dc.identifier.hkuros203775en_US
dc.identifier.volume91en_US
dc.identifier.issue8-
dc.identifier.spage753en_US
dc.identifier.epage758en_US
dc.identifier.eissn1544-0591-
dc.identifier.isiWOS:000306493300005-
dc.publisher.placeUnited States-

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