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Conference Paper: Effects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
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TitleEffects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
 
AuthorsChan, GCF1
Chan, S1
Ho, PL1
Ha, SY1
 
KeywordsDeferasirox (DFRA)
Deferiprone (L1)
Desferrioxamine (DFO)
Infection
Klebsiella pneumoniae
Thalassemia
 
Issue Date2009
 
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.asp
 
CitationThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360 [How to Cite?]
DOI: http://dx.doi.org/10.3109/03630260903211888
 
AbstractInfections are among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO). While encapsulated organisms frequently found in splenectomized patients were readily controlled by prophylactic vaccination and vigilant antibiotic treatment, ferrophilic organisms such as Yersinia and Klebsiella remain common pathogens in thalassemic patients.Yersiniainfections are more prevalent in temperate regions and Klebsiella infections are commonly found in tropical and subtropical areas. While the use of DFO further aggravates the risk of Yersinia infection, oral chelators such as deferiprone (L1) do not enhance the growth of Yersinia in vitro or in vivo. We found that the growth of Klebsiella was marginally enhanced by DFO in vitro when compared to Yersinia. Such an unfavorable effect was not found in either L1 or deferasirox (DFRA) in vitro. The growth of Aeromonas was not affected by the presence of all three forms of chelators. Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients. © Informa UK, Ltd.
 
ISSN0363-0269
2013 Impact Factor: 0.955
 
DOIhttp://dx.doi.org/10.3109/03630260903211888
 
ISI Accession Number IDWOS:000271556200010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, GCF
 
dc.contributor.authorChan, S
 
dc.contributor.authorHo, PL
 
dc.contributor.authorHa, SY
 
dc.date.accessioned2012-08-08T09:06:09Z
 
dc.date.available2012-08-08T09:06:09Z
 
dc.date.issued2009
 
dc.description.abstractInfections are among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO). While encapsulated organisms frequently found in splenectomized patients were readily controlled by prophylactic vaccination and vigilant antibiotic treatment, ferrophilic organisms such as Yersinia and Klebsiella remain common pathogens in thalassemic patients.Yersiniainfections are more prevalent in temperate regions and Klebsiella infections are commonly found in tropical and subtropical areas. While the use of DFO further aggravates the risk of Yersinia infection, oral chelators such as deferiprone (L1) do not enhance the growth of Yersinia in vitro or in vivo. We found that the growth of Klebsiella was marginally enhanced by DFO in vitro when compared to Yersinia. Such an unfavorable effect was not found in either L1 or deferasirox (DFRA) in vitro. The growth of Aeromonas was not affected by the presence of all three forms of chelators. Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients. © Informa UK, Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.description.otherThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360
 
dc.identifier.citationThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360 [How to Cite?]
DOI: http://dx.doi.org/10.3109/03630260903211888
 
dc.identifier.doihttp://dx.doi.org/10.3109/03630260903211888
 
dc.identifier.epage360
 
dc.identifier.hkuros168343
 
dc.identifier.hkuros163809
 
dc.identifier.isiWOS:000271556200010
 
dc.identifier.issn0363-0269
2013 Impact Factor: 0.955
 
dc.identifier.issue5
 
dc.identifier.pmid19814682
 
dc.identifier.scopuseid_2-s2.0-70350701847
 
dc.identifier.spage352
 
dc.identifier.urihttp://hdl.handle.net/10722/159062
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.asp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHemoglobin
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHemoglobin: international journal for hemoglobin research. Copyright © Informa Healthcare.
 
dc.subject.meshAeromonas Hydrophila - Drug Effects - Growth & Development - Isolation & Purification
 
dc.subject.meshBenzoic Acids - Adverse Effects - Pharmacology
 
dc.subject.meshBlood Transfusion
 
dc.subject.meshDeferoxamine - Adverse Effects - Pharmacology
 
dc.subject.meshGram-Negative Bacterial Infections - Chemically Induced - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshIron Chelating Agents - Adverse Effects - Pharmacology
 
dc.subject.meshIron Overload - Drug Therapy - Microbiology
 
dc.subject.meshKinetics
 
dc.subject.meshKlebsiella Infections - Chemically Induced - Epidemiology
 
dc.subject.meshKlebsiella Pneumoniae - Drug Effects - Growth & Development - Isolation & Purification
 
dc.subject.meshPrevalence
 
dc.subject.meshPyridones - Adverse Effects - Pharmacology
 
dc.subject.meshThalassemia - Drug Therapy - Microbiology
 
dc.subject.meshTriazoles - Adverse Effects - Pharmacology
 
dc.subjectDeferasirox (DFRA)
 
dc.subjectDeferiprone (L1)
 
dc.subjectDesferrioxamine (DFO)
 
dc.subjectInfection
 
dc.subjectKlebsiella pneumoniae
 
dc.subjectThalassemia
 
dc.titleEffects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
 
dc.typeConference_Paper
 
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Author Affiliations
  1. The University of Hong Kong