Conference Paper: Effects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleEffects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
AuthorsChan, GCF1
Chan, S1
Ho, PL1
Ha, SY1
KeywordsDeferasirox (DFRA)
Deferiprone (L1)
Desferrioxamine (DFO)
Infection
Klebsiella pneumoniae
Thalassemia
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.asp
CitationThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360 [How to Cite?]
DOI: http://dx.doi.org/10.3109/03630260903211888
AbstractInfections are among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO). While encapsulated organisms frequently found in splenectomized patients were readily controlled by prophylactic vaccination and vigilant antibiotic treatment, ferrophilic organisms such as Yersinia and Klebsiella remain common pathogens in thalassemic patients.Yersiniainfections are more prevalent in temperate regions and Klebsiella infections are commonly found in tropical and subtropical areas. While the use of DFO further aggravates the risk of Yersinia infection, oral chelators such as deferiprone (L1) do not enhance the growth of Yersinia in vitro or in vivo. We found that the growth of Klebsiella was marginally enhanced by DFO in vitro when compared to Yersinia. Such an unfavorable effect was not found in either L1 or deferasirox (DFRA) in vitro. The growth of Aeromonas was not affected by the presence of all three forms of chelators. Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients. © Informa UK, Ltd.
ISSN0363-0269
2011 Impact Factor: 1.304
2011 SCImago Journal Rankings: 0.131
DOIhttp://dx.doi.org/10.3109/03630260903211888
ISI Accession Number IDWOS:000271556200010
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChan, GCF
dc.contributor.authorChan, S
dc.contributor.authorHo, PL
dc.contributor.authorHa, SY
dc.date.accessioned2012-08-08T09:06:09Z
dc.date.available2012-08-08T09:06:09Z
dc.date.issued2009
dc.description.abstractInfections are among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO). While encapsulated organisms frequently found in splenectomized patients were readily controlled by prophylactic vaccination and vigilant antibiotic treatment, ferrophilic organisms such as Yersinia and Klebsiella remain common pathogens in thalassemic patients.Yersiniainfections are more prevalent in temperate regions and Klebsiella infections are commonly found in tropical and subtropical areas. While the use of DFO further aggravates the risk of Yersinia infection, oral chelators such as deferiprone (L1) do not enhance the growth of Yersinia in vitro or in vivo. We found that the growth of Klebsiella was marginally enhanced by DFO in vitro when compared to Yersinia. Such an unfavorable effect was not found in either L1 or deferasirox (DFRA) in vitro. The growth of Aeromonas was not affected by the presence of all three forms of chelators. Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients. © Informa UK, Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.description.otherThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360
dc.identifier.citationThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360 [How to Cite?]
DOI: http://dx.doi.org/10.3109/03630260903211888
dc.identifier.doihttp://dx.doi.org/10.3109/03630260903211888
dc.identifier.epage360
dc.identifier.hkuros168343
dc.identifier.isiWOS:000271556200010
dc.identifier.issn0363-0269
2011 Impact Factor: 1.304
2011 SCImago Journal Rankings: 0.131
dc.identifier.issue5
dc.identifier.pmid19814682
dc.identifier.scopuseid_2-s2.0-70350701847
dc.identifier.spage352
dc.identifier.urihttp://hdl.handle.net/10722/159062
dc.identifier.volume33
dc.languageeng
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.asp
dc.publisher.placeUnited Kingdom
dc.relation.ispartofHemoglobin
dc.relation.referencesReferences in Scopus
dc.rightsHemoglobin: international journal for hemoglobin research. Copyright © Informa Healthcare.
dc.subject.meshAeromonas Hydrophila - Drug Effects - Growth & Development - Isolation & Purification
dc.subject.meshBenzoic Acids - Adverse Effects - Pharmacology
dc.subject.meshBlood Transfusion
dc.subject.meshDeferoxamine - Adverse Effects - Pharmacology
dc.subject.meshGram-Negative Bacterial Infections - Chemically Induced - Epidemiology
dc.subject.meshHumans
dc.subject.meshIron Chelating Agents - Adverse Effects - Pharmacology
dc.subject.meshIron Overload - Drug Therapy - Microbiology
dc.subject.meshKinetics
dc.subject.meshKlebsiella Infections - Chemically Induced - Epidemiology
dc.subject.meshKlebsiella Pneumoniae - Drug Effects - Growth & Development - Isolation & Purification
dc.subject.meshPrevalence
dc.subject.meshPyridones - Adverse Effects - Pharmacology
dc.subject.meshThalassemia - Drug Therapy - Microbiology
dc.subject.meshTriazoles - Adverse Effects - Pharmacology
dc.subjectDeferasirox (DFRA)
dc.subjectDeferiprone (L1)
dc.subjectDesferrioxamine (DFO)
dc.subjectInfection
dc.subjectKlebsiella pneumoniae
dc.subjectThalassemia
dc.titleEffects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
dc.typeConference_Paper
Author Affiliations
  1. The University of Hong Kong