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Conference Paper: Effects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients

TitleEffects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
Authors
KeywordsDeferasirox (DFRA)
Deferiprone (L1)
Desferrioxamine (DFO)
Infection
Klebsiella pneumoniae
Thalassemia
Issue Date2009
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.asp
Citation
The 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360 How to Cite?
Abstract
Infections are among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO). While encapsulated organisms frequently found in splenectomized patients were readily controlled by prophylactic vaccination and vigilant antibiotic treatment, ferrophilic organisms such as Yersinia and Klebsiella remain common pathogens in thalassemic patients.Yersiniainfections are more prevalent in temperate regions and Klebsiella infections are commonly found in tropical and subtropical areas. While the use of DFO further aggravates the risk of Yersinia infection, oral chelators such as deferiprone (L1) do not enhance the growth of Yersinia in vitro or in vivo. We found that the growth of Klebsiella was marginally enhanced by DFO in vitro when compared to Yersinia. Such an unfavorable effect was not found in either L1 or deferasirox (DFRA) in vitro. The growth of Aeromonas was not affected by the presence of all three forms of chelators. Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients. © Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/159062
ISSN
2013 Impact Factor: 0.955
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChan, GCFen_US
dc.contributor.authorChan, Sen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorHa, SYen_US
dc.date.accessioned2012-08-08T09:06:09Z-
dc.date.available2012-08-08T09:06:09Z-
dc.date.issued2009en_US
dc.identifier.citationThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360en_US
dc.identifier.issn0363-0269en_US
dc.identifier.urihttp://hdl.handle.net/10722/159062-
dc.description.abstractInfections are among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO). While encapsulated organisms frequently found in splenectomized patients were readily controlled by prophylactic vaccination and vigilant antibiotic treatment, ferrophilic organisms such as Yersinia and Klebsiella remain common pathogens in thalassemic patients.Yersiniainfections are more prevalent in temperate regions and Klebsiella infections are commonly found in tropical and subtropical areas. While the use of DFO further aggravates the risk of Yersinia infection, oral chelators such as deferiprone (L1) do not enhance the growth of Yersinia in vitro or in vivo. We found that the growth of Klebsiella was marginally enhanced by DFO in vitro when compared to Yersinia. Such an unfavorable effect was not found in either L1 or deferasirox (DFRA) in vitro. The growth of Aeromonas was not affected by the presence of all three forms of chelators. Therefore, we suggest that factors other than DFO may account for the increased prevalence of Klebsiella and Aeromonas infection in Asian thalassemic patients. © Informa UK, Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03630269.aspen_US
dc.relation.ispartofHemoglobinen_US
dc.rightsHemoglobin: international journal for hemoglobin research. Copyright © Informa Healthcare.-
dc.subjectDeferasirox (DFRA)-
dc.subjectDeferiprone (L1)-
dc.subjectDesferrioxamine (DFO)-
dc.subjectInfection-
dc.subjectKlebsiella pneumoniae-
dc.subjectThalassemia-
dc.subject.meshAeromonas Hydrophila - Drug Effects - Growth & Development - Isolation & Purificationen_US
dc.subject.meshBenzoic Acids - Adverse Effects - Pharmacologyen_US
dc.subject.meshBlood Transfusionen_US
dc.subject.meshDeferoxamine - Adverse Effects - Pharmacologyen_US
dc.subject.meshGram-Negative Bacterial Infections - Chemically Induced - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIron Chelating Agents - Adverse Effects - Pharmacologyen_US
dc.subject.meshIron Overload - Drug Therapy - Microbiologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshKlebsiella Infections - Chemically Induced - Epidemiologyen_US
dc.subject.meshKlebsiella Pneumoniae - Drug Effects - Growth & Development - Isolation & Purificationen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPyridones - Adverse Effects - Pharmacologyen_US
dc.subject.meshThalassemia - Drug Therapy - Microbiologyen_US
dc.subject.meshTriazoles - Adverse Effects - Pharmacologyen_US
dc.titleEffects of chelators (Deferoxamine, deferiprone and deferasirox) on the growth of klebsiella pneumoniae and aeromonas hydrophila isolated from transfusion-dependent thalassemia patientsen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.authorityChan, GCF=rp00431en_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/03630260903211888en_US
dc.identifier.pmid19814682en_US
dc.identifier.scopuseid_2-s2.0-70350701847en_US
dc.identifier.hkuros168343-
dc.identifier.hkuros163809-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350701847&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue5en_US
dc.identifier.spage352en_US
dc.identifier.epage360en_US
dc.identifier.isiWOS:000271556200010-
dc.publisher.placeUnited Kingdomen_US
dc.description.otherThe 17th International Conference on Chelation (ICOC), Shenzhen, China, 23-27 November 2007. In Hemoglobin, 2009, v. 33 n. 5, p. 352-360-
dc.identifier.scopusauthoridChan, GCF=16160154400en_US
dc.identifier.scopusauthoridChan, S=35071039700en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridHa, SY=7202501115en_US

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