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Conference Paper: PHBV/PLLA-based composite scaffolds containing nano-sized hydroxyapatite particles for bone tissue engineering

TitlePHBV/PLLA-based composite scaffolds containing nano-sized hydroxyapatite particles for bone tissue engineering
Authors
KeywordsCrystallinity
Degradation
Freeze Drying
Poly (L-Lactic Acid)
Poly(Hydroxybutyrate-Co-Hydroxyvalerate)
Polymer Blend
Porosity
Scaffold
Issue Date2008
PublisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/17458080.asp
Citation
Journal Of Experimental Nanoscience, 2008, v. 3 n. 2, p. 121-132 How to Cite?
AbstractComposite scaffolds made of PHBV/PLLA blends and nano-sized hydroxyapatite (HA) particles can be useful for bone tissue engineering as different blends of PHBV with PLLA should have higher degradation rates than PHBV itself and scaffolds containing bioactive HA particles will provide desired osteoconductivity. In this investigation, composite scaffolds were produced via an emulsion freezing/freeze-drying process and subsequently characterised using several techniques. Highly porous and interconnected scaffolds with porosity greater than 70% could be made. It was found that the crystallinity of PHBV in the scaffolds was decreased due to blending with the PLLA polymer, which is beneficial for the faster degradation of the scaffolds in vitro and in vivo. It was shown that the incorporation of HA nanoparticles enhanced compressive mechanical properties of scaffolds.
Persistent Identifierhttp://hdl.handle.net/10722/158988
ISSN
2015 Impact Factor: 0.832
2015 SCImago Journal Rankings: 0.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSultana, Nen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-08T09:04:58Z-
dc.date.available2012-08-08T09:04:58Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Experimental Nanoscience, 2008, v. 3 n. 2, p. 121-132en_US
dc.identifier.issn1745-8080en_US
dc.identifier.urihttp://hdl.handle.net/10722/158988-
dc.description.abstractComposite scaffolds made of PHBV/PLLA blends and nano-sized hydroxyapatite (HA) particles can be useful for bone tissue engineering as different blends of PHBV with PLLA should have higher degradation rates than PHBV itself and scaffolds containing bioactive HA particles will provide desired osteoconductivity. In this investigation, composite scaffolds were produced via an emulsion freezing/freeze-drying process and subsequently characterised using several techniques. Highly porous and interconnected scaffolds with porosity greater than 70% could be made. It was found that the crystallinity of PHBV in the scaffolds was decreased due to blending with the PLLA polymer, which is beneficial for the faster degradation of the scaffolds in vitro and in vivo. It was shown that the incorporation of HA nanoparticles enhanced compressive mechanical properties of scaffolds.en_US
dc.languageengen_US
dc.publisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/17458080.aspen_US
dc.relation.ispartofJournal of Experimental Nanoscienceen_US
dc.subjectCrystallinityen_US
dc.subjectDegradationen_US
dc.subjectFreeze Dryingen_US
dc.subjectPoly (L-Lactic Acid)en_US
dc.subjectPoly(Hydroxybutyrate-Co-Hydroxyvalerate)en_US
dc.subjectPolymer Blenden_US
dc.subjectPorosityen_US
dc.subjectScaffolden_US
dc.titlePHBV/PLLA-based composite scaffolds containing nano-sized hydroxyapatite particles for bone tissue engineeringen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, M:memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/17458080701867429en_US
dc.identifier.scopuseid_2-s2.0-47949130706en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47949130706&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume3en_US
dc.identifier.issue2en_US
dc.identifier.spage121en_US
dc.identifier.epage132en_US
dc.identifier.isiWOS:000257543600004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSultana, N=15849681300en_US
dc.identifier.scopusauthoridWang, M=15749714100en_US

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