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Conference Paper: In vivo study of the rat patellar tendon healing - histological, biochemical and biomechanical aspects

TitleIn vivo study of the rat patellar tendon healing - histological, biochemical and biomechanical aspects
Authors
Issue Date1998
Citation
Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 1998, v. 5, p. 2471-2473 How to Cite?
AbstractPatellar tendon central one third is removed during anterior cruciate ligament reconstruction. The current study investigates an in vivo model of patellar tendon healing, histologically, biochemically and biomechanically. The histological appearance and the ultimate stress of the central one third patellar tendon were studied over time. The specimens were also analyzed for collagen and non-reducible crosslinks, as measured by hydroxyproline and pyridinoline content, respectively. Thirty days post-injury, the cellularity and the collagen matrix approached a normal tendon. The ultimate stress of the healing tendon restored to an average of 71% of the control and remained constant over time. The pyridinoline of the healing tendon was twice the values for the controls by 30 days and then reached a plateau. However, the hydroxyproline did not change significantly over time. Stepwise regression analysis demonstrated that pyridinoline was a better biochemical marker for the ultimate stress than hydroxyproline. The current study provides insights into the healing process in tendon by establishing the relationship between the biochemical parameters with the ultimate stress. This study also suggests the possibility of using pyridinoline content as an indirect marker of the ultimate stress, since in vivo clinical assessment is impossible.
Persistent Identifierhttp://hdl.handle.net/10722/158925
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChan, BPen_US
dc.contributor.authorFu, SCen_US
dc.contributor.authorQin, Len_US
dc.contributor.authorChan, KMen_US
dc.date.accessioned2012-08-08T09:04:37Z-
dc.date.available2012-08-08T09:04:37Z-
dc.date.issued1998en_US
dc.identifier.citationAnnual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 1998, v. 5, p. 2471-2473en_US
dc.identifier.issn0589-1019en_US
dc.identifier.urihttp://hdl.handle.net/10722/158925-
dc.description.abstractPatellar tendon central one third is removed during anterior cruciate ligament reconstruction. The current study investigates an in vivo model of patellar tendon healing, histologically, biochemically and biomechanically. The histological appearance and the ultimate stress of the central one third patellar tendon were studied over time. The specimens were also analyzed for collagen and non-reducible crosslinks, as measured by hydroxyproline and pyridinoline content, respectively. Thirty days post-injury, the cellularity and the collagen matrix approached a normal tendon. The ultimate stress of the healing tendon restored to an average of 71% of the control and remained constant over time. The pyridinoline of the healing tendon was twice the values for the controls by 30 days and then reached a plateau. However, the hydroxyproline did not change significantly over time. Stepwise regression analysis demonstrated that pyridinoline was a better biochemical marker for the ultimate stress than hydroxyproline. The current study provides insights into the healing process in tendon by establishing the relationship between the biochemical parameters with the ultimate stress. This study also suggests the possibility of using pyridinoline content as an indirect marker of the ultimate stress, since in vivo clinical assessment is impossible.en_US
dc.languageengen_US
dc.relation.ispartofAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedingsen_US
dc.titleIn vivo study of the rat patellar tendon healing - histological, biochemical and biomechanical aspectsen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, BP:bpchan@hkucc.hku.hken_US
dc.identifier.authorityChan, BP=rp00087en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0032267782en_US
dc.identifier.volume5en_US
dc.identifier.spage2471en_US
dc.identifier.epage2473en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, BP=7201530390en_US
dc.identifier.scopusauthoridFu, SC=7402732268en_US
dc.identifier.scopusauthoridQin, L=24449633900en_US
dc.identifier.scopusauthoridChan, KM=7406034671en_US

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