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Conference Paper: In vivo manganese-enhanced MRI and diffusion tensor imaging of developing and impaired visual brains

TitleIn vivo manganese-enhanced MRI and diffusion tensor imaging of developing and impaired visual brains
Authors
KeywordsCorpus callosum
Diffusion tensor imaging
Fractional anisotropy
Functional activities
High resolution
Issue Date2011
PublisherIEEE.
Citation
The 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2011), Boston, MA., 30 August-3 September 2011. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2011, p. 7005-7008 How to Cite?
AbstractThis study explored the feasibility of high-resolution Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) for in vivo assessments of the development and reorganization of retinal and visual callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Using MEMRI, intravitreal Mn 2+ injection into one eye resulted in maximal T1-weighted hyperintensity in neonatal contralateral superior colliculus (SC) 8 hours after administration, whereas in adult contralateral SC signal increase continued at 1 day post-injection. Notably, mild but significant Mn 2+ enhancement was observed in the ipsilateral SC in normal neonatal rats, and in adult rats after neonatal monocular enucleation (ME) but not in normal adult rats. Upon intracortical Mn 2+ injection to the visual cortex, neonatal binocularly-enucleated (BE) rats showed an enhancement of a larger projection area, via the splenium of corpus callosum to the V1/V2 transition zone of the contralateral hemisphere in comparison to normal rats. For DTI, the retinal pathways projected from the enucleated eyes possessed lower fractional anisotropy (FA) 6 weeks after BE and ME. Interestingly, in the optic nerve projected from the remaining eye in ME rats a significantly higher FA was observed compared to normal rats. The results of this study are potentially important for understanding the axonal transport, microstructural reorganization and functional activities in the living visual brain during early postnatal development and plasticity in a global and longitudinal setting. © 2011 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/158763
ISBN
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorCheng, JSen_HK
dc.contributor.authorFan, Sen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-08-08T09:01:13Z-
dc.date.available2012-08-08T09:01:13Z-
dc.date.issued2011en_HK
dc.identifier.citationThe 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2011), Boston, MA., 30 August-3 September 2011. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2011, p. 7005-7008en_US
dc.identifier.isbn978-1-4244-4122-8-
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/158763-
dc.description.abstractThis study explored the feasibility of high-resolution Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) for in vivo assessments of the development and reorganization of retinal and visual callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Using MEMRI, intravitreal Mn 2+ injection into one eye resulted in maximal T1-weighted hyperintensity in neonatal contralateral superior colliculus (SC) 8 hours after administration, whereas in adult contralateral SC signal increase continued at 1 day post-injection. Notably, mild but significant Mn 2+ enhancement was observed in the ipsilateral SC in normal neonatal rats, and in adult rats after neonatal monocular enucleation (ME) but not in normal adult rats. Upon intracortical Mn 2+ injection to the visual cortex, neonatal binocularly-enucleated (BE) rats showed an enhancement of a larger projection area, via the splenium of corpus callosum to the V1/V2 transition zone of the contralateral hemisphere in comparison to normal rats. For DTI, the retinal pathways projected from the enucleated eyes possessed lower fractional anisotropy (FA) 6 weeks after BE and ME. Interestingly, in the optic nerve projected from the remaining eye in ME rats a significantly higher FA was observed compared to normal rats. The results of this study are potentially important for understanding the axonal transport, microstructural reorganization and functional activities in the living visual brain during early postnatal development and plasticity in a global and longitudinal setting. © 2011 IEEE.en_HK
dc.languageengen_US
dc.publisherIEEE.-
dc.relation.ispartofProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBSen_HK
dc.rightsIEEE Engineering in Medicine and Biology Society Conference Proceedings. Copyright © IEEE.-
dc.rights©2011 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCorpus callosum-
dc.subjectDiffusion tensor imaging-
dc.subjectFractional anisotropy-
dc.subjectFunctional activities-
dc.subjectHigh resolution-
dc.titleIn vivo manganese-enhanced MRI and diffusion tensor imaging of developing and impaired visual brainsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailZhou, IY: izhou@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityZhou, IY=rp01739en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1109/IEMBS.2011.6091771en_HK
dc.identifier.scopuseid_2-s2.0-84055200427en_HK
dc.identifier.hkuros206811-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84055200427&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage7005en_HK
dc.identifier.epage7008en_HK
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2011), Boston, MA., 30 August-3 September 2011. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2011, p. 7005-7008-
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridCheng, JS=55443910700en_HK
dc.identifier.scopusauthoridFan, S=36514618100en_HK
dc.identifier.scopusauthoridZhou, IY=35424838500en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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