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Conference Paper: Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron

TitleMagnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2010, v. 1202, p. 115-122 How to Cite?
AbstractWith transfusional iron overload, almost all the excess iron is sequestered intracellularly as rapidly mobilizable, dispersed, soluble ferritin iron, and as aggregated, insoluble hemosiderin iron for long-term storage. Established magnetic resonance imaging (MRI) indicators of tissue iron (R 2, R 2*) are principally influenced by hemosiderin iron and change slowly, even with intensive iron chelation. Intracellular ferritin iron is evidently in equilibrium with the low-molecular-weight cytosolic iron pool that can change rapidly with iron chelation. We have developed a new MRI method to separately measure ferritin and hemosiderin iron, based on the non-monoexponential signal decay induced by aggregated iron in multiple-spin-echo sequences. We have initially validated the method in agarose phantoms and in human liver explants and shown the feasibility of its application in patients with thalassemia major. Measurement of tissue ferritin iron is a promising new means to rapidly evaluate the effectiveness of iron-chelating regimens. © 2010 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/158647
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health National Institutes of HealthR01-DK069373
R01-DK066251
R01-DK049108
American Heart Association
Hong Kong Research Grant CouncilGRF HKU 7794/07M
0730143N
Funding Information:

This research was supported, in part, by the National Institutes of Health National Institutes of Health (R01-DK069373, R01-DK066251, and R01-DK049108); the American Heart Association; (0730143N); and the Hong Kong Research Grant Council (GRF HKU 7794/07M).

References

 

DC FieldValueLanguage
dc.contributor.authorWu, EXen_US
dc.contributor.authorKim, Den_US
dc.contributor.authorTosti, CLen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorJensen, JHen_US
dc.contributor.authorCheung, JSen_US
dc.contributor.authorFeng, Len_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorHa, SYen_US
dc.contributor.authorSheth, SSen_US
dc.contributor.authorBrown, TRen_US
dc.contributor.authorBrittenham, GMen_US
dc.date.accessioned2012-08-08T09:00:39Z-
dc.date.available2012-08-08T09:00:39Z-
dc.date.issued2010en_US
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2010, v. 1202, p. 115-122en_US
dc.identifier.issn0077-8923en_US
dc.identifier.urihttp://hdl.handle.net/10722/158647-
dc.description.abstractWith transfusional iron overload, almost all the excess iron is sequestered intracellularly as rapidly mobilizable, dispersed, soluble ferritin iron, and as aggregated, insoluble hemosiderin iron for long-term storage. Established magnetic resonance imaging (MRI) indicators of tissue iron (R 2, R 2*) are principally influenced by hemosiderin iron and change slowly, even with intensive iron chelation. Intracellular ferritin iron is evidently in equilibrium with the low-molecular-weight cytosolic iron pool that can change rapidly with iron chelation. We have developed a new MRI method to separately measure ferritin and hemosiderin iron, based on the non-monoexponential signal decay induced by aggregated iron in multiple-spin-echo sequences. We have initially validated the method in agarose phantoms and in human liver explants and shown the feasibility of its application in patients with thalassemia major. Measurement of tissue ferritin iron is a promising new means to rapidly evaluate the effectiveness of iron-chelating regimens. © 2010 New York Academy of Sciences.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.subject.meshFerritins - Chemistry - Metabolismen_US
dc.subject.meshHemosiderin - Chemistry - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshIron - Chemistry - Metabolismen_US
dc.subject.meshIron Overload - Metabolismen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMagnetic Resonance Imaging - Instrumentation - Methodsen_US
dc.subject.meshPhantoms, Imagingen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.titleMagnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin ironen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1749-6632.2010.05587.xen_US
dc.identifier.pmid20712781-
dc.identifier.scopuseid_2-s2.0-77955885409en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955885409&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1202en_US
dc.identifier.spage115en_US
dc.identifier.epage122en_US
dc.identifier.isiWOS:000283099600018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US
dc.identifier.scopusauthoridKim, D=8524290700en_US
dc.identifier.scopusauthoridTosti, CL=10641524200en_US
dc.identifier.scopusauthoridTang, H=36827331000en_US
dc.identifier.scopusauthoridJensen, JH=7404521984en_US
dc.identifier.scopusauthoridCheung, JS=16174280400en_US
dc.identifier.scopusauthoridFeng, L=41761336100en_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridHa, SY=7202501115en_US
dc.identifier.scopusauthoridSheth, SS=7102603512en_US
dc.identifier.scopusauthoridBrown, TR=7404319370en_US
dc.identifier.scopusauthoridBrittenham, GM=7005583587en_US

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