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Conference Paper: Puncture Depth and the Mechanical Stability of Microneedles

TitlePuncture Depth and the Mechanical Stability of Microneedles
Authors
KeywordsSilicone Rubber
Punctures
Microneedles
Mechanical Behaviour
Drug Delivery
Issue Date2008
Citation
The 1st International Conference on Biomedical Electronics and Devices (BIODEVICES 2008), Funchal, Madeira, Portugal, 28-31 January 2008. In BIODEVICES 2008: Proceedings of the 1st International Conference on Biomedical Electronics and Devices, 2008, v. 2, p. 291-296 How to Cite?
AbstractMicroneedles penetrating less than 1mm beneath the skin can deliver the drugs directly without piercing blood vessels or damaging nerves. The mechanical stability and the puncture behaviour were investigated experimentally by inserting steel needles into silicone rubber and pig skin. Puncture tests revealed that the length of needle buried in the flesh is less than 50% of the nominal insertion depth when the insertion depth is less 1mm. The mechanical stability of the buried needle-flesh assembly, characterized by the force needed to retract the needle, decreased with buried depth and needle diameter. Analysis of the load data suggested that a 100-micron diameter microneedle buried 100 microns deep in pig skin would have a retraction force of 0.1mN, which is only 1% of the retraction force of a conventional needle inserted 5mm into the skin. This suggests that the usage of microneedles in arrays is necessary to increase stability and to enable stable drug delivery.
Persistent Identifierhttp://hdl.handle.net/10722/158565
ISBN
References

 

DC FieldValueLanguage
dc.contributor.authorLam, DCCen_US
dc.contributor.authorLee, YHen_US
dc.contributor.authorShek, KTen_US
dc.contributor.authorPang, Gen_US
dc.date.accessioned2012-08-08T09:00:17Z-
dc.date.available2012-08-08T09:00:17Z-
dc.date.issued2008en_US
dc.identifier.citationThe 1st International Conference on Biomedical Electronics and Devices (BIODEVICES 2008), Funchal, Madeira, Portugal, 28-31 January 2008. In BIODEVICES 2008: Proceedings of the 1st International Conference on Biomedical Electronics and Devices, 2008, v. 2, p. 291-296en_US
dc.identifier.isbn978-989811117-3-
dc.identifier.urihttp://hdl.handle.net/10722/158565-
dc.description.abstractMicroneedles penetrating less than 1mm beneath the skin can deliver the drugs directly without piercing blood vessels or damaging nerves. The mechanical stability and the puncture behaviour were investigated experimentally by inserting steel needles into silicone rubber and pig skin. Puncture tests revealed that the length of needle buried in the flesh is less than 50% of the nominal insertion depth when the insertion depth is less 1mm. The mechanical stability of the buried needle-flesh assembly, characterized by the force needed to retract the needle, decreased with buried depth and needle diameter. Analysis of the load data suggested that a 100-micron diameter microneedle buried 100 microns deep in pig skin would have a retraction force of 0.1mN, which is only 1% of the retraction force of a conventional needle inserted 5mm into the skin. This suggests that the usage of microneedles in arrays is necessary to increase stability and to enable stable drug delivery.en_US
dc.languageengen_US
dc.relation.ispartofBIODEVICES 2008: Proceedings of the 1st International Conference on Biomedical Electronics and Devicesen_US
dc.subjectSilicone Rubberen_US
dc.subjectPuncturesen_US
dc.subjectMicroneedlesen_US
dc.subjectMechanical Behaviouren_US
dc.subjectDrug Deliveryen_US
dc.titlePuncture Depth and the Mechanical Stability of Microneedlesen_US
dc.typeConference_Paperen_US
dc.identifier.emailPang, G: gpang@eee.hku.hken_US
dc.identifier.authorityPang, G=rp00162en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-55649088227en_US
dc.identifier.hkuros168567-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55649088227&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2en_US
dc.identifier.spage291en_US
dc.identifier.epage296en_US
dc.identifier.scopusauthoridPang, G=7103393283en_US
dc.identifier.scopusauthoridShek, KT=8557567900en_US
dc.identifier.scopusauthoridLee, YH=25638933300en_US
dc.identifier.scopusauthoridLam, DCC=24280283500en_US
dc.customcontrol.immutablesml 140815-

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