File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Conference Paper: Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins
  • Basic View
  • Metadata View
  • XML View
TitlePattern of mineralization after regenerative periodontal therapy with enamel matrix proteins
 
AuthorsBosshardt, DD3 3
Sculean, A2
Donos, N1
Lang, NP3
 
Issue Date2006
 
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EOS
 
CitationEuropean Journal Of Oral Sciences, 2006, v. 114 SUPPL. 1, p. 225-231 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0722.2006.00300.x
 
AbstractA derivative (EMD) of enamel matrix proteins (EMPs) is used for periodontal regeneration because EMPs are believed to induce the formation of acellular extrinsic fiber cementum (AEFC). Other reports, however, indicate that EMPs have osteogenic potential. The aim of this study was to characterize the nature of the tissue that forms on the root surface following application of EMD. Ten human teeth affected by periodontitis and scheduled for extraction were treated with EMD. Four to six weeks later, they were extracted and processed for analysis by light microscopy and transmission electron microscopy. Immunocytochemistry with antibodies against bone sialoprotein (BSP) and osteopontin (OPN) was performed to determine the mineralization pattern. The newly formed tissues on the root were thick and contained embedded cells. Small mineralization foci were regularly seen, and large organic matrix patches were occasionally seen, but a distinct mineralization front was lacking. While labeling for BSP was always associated with small mineralization foci and large matrix patches, OPN labeling was seen inconsistently. It is concluded that tissues resembling either cellular intrinsic fiber cementum or a type of bone were observed. The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern. © Eur J Oral Sci, 2006.
 
ISSN0909-8836
2012 Impact Factor: 1.42
2012 SCImago Journal Rankings: 0.690
 
DOIhttp://dx.doi.org/10.1111/j.1600-0722.2006.00300.x
 
ISI Accession Number IDWOS:000240404800038
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorBosshardt, DD
 
dc.contributor.authorSculean, A
 
dc.contributor.authorDonos, N
 
dc.contributor.authorLang, NP
 
dc.date.accessioned2012-08-08T08:57:09Z
 
dc.date.available2012-08-08T08:57:09Z
 
dc.date.issued2006
 
dc.description.abstractA derivative (EMD) of enamel matrix proteins (EMPs) is used for periodontal regeneration because EMPs are believed to induce the formation of acellular extrinsic fiber cementum (AEFC). Other reports, however, indicate that EMPs have osteogenic potential. The aim of this study was to characterize the nature of the tissue that forms on the root surface following application of EMD. Ten human teeth affected by periodontitis and scheduled for extraction were treated with EMD. Four to six weeks later, they were extracted and processed for analysis by light microscopy and transmission electron microscopy. Immunocytochemistry with antibodies against bone sialoprotein (BSP) and osteopontin (OPN) was performed to determine the mineralization pattern. The newly formed tissues on the root were thick and contained embedded cells. Small mineralization foci were regularly seen, and large organic matrix patches were occasionally seen, but a distinct mineralization front was lacking. While labeling for BSP was always associated with small mineralization foci and large matrix patches, OPN labeling was seen inconsistently. It is concluded that tissues resembling either cellular intrinsic fiber cementum or a type of bone were observed. The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern. © Eur J Oral Sci, 2006.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Oral Sciences, 2006, v. 114 SUPPL. 1, p. 225-231 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0722.2006.00300.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0722.2006.00300.x
 
dc.identifier.epage231
 
dc.identifier.isiWOS:000240404800038
 
dc.identifier.issn0909-8836
2012 Impact Factor: 1.42
2012 SCImago Journal Rankings: 0.690
 
dc.identifier.issueSUPPL. 1
 
dc.identifier.pmid16674690
 
dc.identifier.scopuseid_2-s2.0-33646512798
 
dc.identifier.spage225
 
dc.identifier.urihttp://hdl.handle.net/10722/157955
 
dc.identifier.volume114
 
dc.languageeng
 
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EOS
 
dc.publisher.placeDenmark
 
dc.relation.ispartofEuropean Journal of Oral Sciences
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCalcification, Physiologic - Drug Effects
 
dc.subject.meshCementogenesis - Drug Effects
 
dc.subject.meshDental Cementum - Drug Effects - Ultrastructure
 
dc.subject.meshDental Enamel Proteins - Therapeutic Use
 
dc.subject.meshGuided Tissue Regeneration, Periodontal - Methods
 
dc.subject.meshHumans
 
dc.subject.meshImmunohistochemistry
 
dc.subject.meshIntegrin-Binding Sialoprotein
 
dc.subject.meshMicroscopy, Electron, Transmission
 
dc.subject.meshOsteogenesis - Drug Effects
 
dc.subject.meshOsteopontin
 
dc.subject.meshPeriodontal Ligament - Drug Effects
 
dc.subject.meshPeriodontitis - Therapy
 
dc.subject.meshPhosphoproteins - Analysis
 
dc.subject.meshSialoglycoproteins - Analysis
 
dc.subject.meshTooth Root - Drug Effects - Ultrastructure
 
dc.titlePattern of mineralization after regenerative periodontal therapy with enamel matrix proteins
 
dc.typeConference_Paper
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Bosshardt, DD</contributor.author>
<contributor.author>Sculean, A</contributor.author>
<contributor.author>Donos, N</contributor.author>
<contributor.author>Lang, NP</contributor.author>
<date.accessioned>2012-08-08T08:57:09Z</date.accessioned>
<date.available>2012-08-08T08:57:09Z</date.available>
<date.issued>2006</date.issued>
<identifier.citation>European Journal Of Oral Sciences, 2006, v. 114 SUPPL. 1, p. 225-231</identifier.citation>
<identifier.issn>0909-8836</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/157955</identifier.uri>
<description.abstract>A derivative (EMD) of enamel matrix proteins (EMPs) is used for periodontal regeneration because EMPs are believed to induce the formation of acellular extrinsic fiber cementum (AEFC). Other reports, however, indicate that EMPs have osteogenic potential. The aim of this study was to characterize the nature of the tissue that forms on the root surface following application of EMD. Ten human teeth affected by periodontitis and scheduled for extraction were treated with EMD. Four to six weeks later, they were extracted and processed for analysis by light microscopy and transmission electron microscopy. Immunocytochemistry with antibodies against bone sialoprotein (BSP) and osteopontin (OPN) was performed to determine the mineralization pattern. The newly formed tissues on the root were thick and contained embedded cells. Small mineralization foci were regularly seen, and large organic matrix patches were occasionally seen, but a distinct mineralization front was lacking. While labeling for BSP was always associated with small mineralization foci and large matrix patches, OPN labeling was seen inconsistently. It is concluded that tissues resembling either cellular intrinsic fiber cementum or a type of bone were observed. The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern. &#169; Eur J Oral Sci, 2006.</description.abstract>
<language>eng</language>
<publisher>Blackwell Munksgaard. The Journal&apos;s web site is located at http://www.blackwellpublishing.com/journals/EOS</publisher>
<relation.ispartof>European Journal of Oral Sciences</relation.ispartof>
<subject.mesh>Calcification, Physiologic - Drug Effects</subject.mesh>
<subject.mesh>Cementogenesis - Drug Effects</subject.mesh>
<subject.mesh>Dental Cementum - Drug Effects - Ultrastructure</subject.mesh>
<subject.mesh>Dental Enamel Proteins - Therapeutic Use</subject.mesh>
<subject.mesh>Guided Tissue Regeneration, Periodontal - Methods</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Immunohistochemistry</subject.mesh>
<subject.mesh>Integrin-Binding Sialoprotein</subject.mesh>
<subject.mesh>Microscopy, Electron, Transmission</subject.mesh>
<subject.mesh>Osteogenesis - Drug Effects</subject.mesh>
<subject.mesh>Osteopontin</subject.mesh>
<subject.mesh>Periodontal Ligament - Drug Effects</subject.mesh>
<subject.mesh>Periodontitis - Therapy</subject.mesh>
<subject.mesh>Phosphoproteins - Analysis</subject.mesh>
<subject.mesh>Sialoglycoproteins - Analysis</subject.mesh>
<subject.mesh>Tooth Root - Drug Effects - Ultrastructure</subject.mesh>
<title>Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins</title>
<type>Conference_Paper</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1111/j.1600-0722.2006.00300.x</identifier.doi>
<identifier.pmid>16674690</identifier.pmid>
<identifier.scopus>eid_2-s2.0-33646512798</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-33646512798&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>114</identifier.volume>
<identifier.issue>SUPPL. 1</identifier.issue>
<identifier.spage>225</identifier.spage>
<identifier.epage>231</identifier.epage>
<identifier.isi>WOS:000240404800038</identifier.isi>
<publisher.place>Denmark</publisher.place>
</item>
Author Affiliations
  1. UCL Eastman Dental Institute
  2. Radboud University Nijmegen Medical Centre
  3. Universität Bern