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Conference Paper: Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins

TitlePattern of mineralization after regenerative periodontal therapy with enamel matrix proteins
Authors
Issue Date2006
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EOS
Citation
European Journal Of Oral Sciences, 2006, v. 114 SUPPL. 1, p. 225-231 How to Cite?
Abstract
A derivative (EMD) of enamel matrix proteins (EMPs) is used for periodontal regeneration because EMPs are believed to induce the formation of acellular extrinsic fiber cementum (AEFC). Other reports, however, indicate that EMPs have osteogenic potential. The aim of this study was to characterize the nature of the tissue that forms on the root surface following application of EMD. Ten human teeth affected by periodontitis and scheduled for extraction were treated with EMD. Four to six weeks later, they were extracted and processed for analysis by light microscopy and transmission electron microscopy. Immunocytochemistry with antibodies against bone sialoprotein (BSP) and osteopontin (OPN) was performed to determine the mineralization pattern. The newly formed tissues on the root were thick and contained embedded cells. Small mineralization foci were regularly seen, and large organic matrix patches were occasionally seen, but a distinct mineralization front was lacking. While labeling for BSP was always associated with small mineralization foci and large matrix patches, OPN labeling was seen inconsistently. It is concluded that tissues resembling either cellular intrinsic fiber cementum or a type of bone were observed. The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern. © Eur J Oral Sci, 2006.
Persistent Identifierhttp://hdl.handle.net/10722/157955
ISSN
2013 Impact Factor: 1.729
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBosshardt, DDen_US
dc.contributor.authorSculean, Aen_US
dc.contributor.authorDonos, Nen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:57:09Z-
dc.date.available2012-08-08T08:57:09Z-
dc.date.issued2006en_US
dc.identifier.citationEuropean Journal Of Oral Sciences, 2006, v. 114 SUPPL. 1, p. 225-231en_US
dc.identifier.issn0909-8836en_US
dc.identifier.urihttp://hdl.handle.net/10722/157955-
dc.description.abstractA derivative (EMD) of enamel matrix proteins (EMPs) is used for periodontal regeneration because EMPs are believed to induce the formation of acellular extrinsic fiber cementum (AEFC). Other reports, however, indicate that EMPs have osteogenic potential. The aim of this study was to characterize the nature of the tissue that forms on the root surface following application of EMD. Ten human teeth affected by periodontitis and scheduled for extraction were treated with EMD. Four to six weeks later, they were extracted and processed for analysis by light microscopy and transmission electron microscopy. Immunocytochemistry with antibodies against bone sialoprotein (BSP) and osteopontin (OPN) was performed to determine the mineralization pattern. The newly formed tissues on the root were thick and contained embedded cells. Small mineralization foci were regularly seen, and large organic matrix patches were occasionally seen, but a distinct mineralization front was lacking. While labeling for BSP was always associated with small mineralization foci and large matrix patches, OPN labeling was seen inconsistently. It is concluded that tissues resembling either cellular intrinsic fiber cementum or a type of bone were observed. The mineralization pattern mostly resembled that found in bone, except for a few areas that exhibited a hitherto undescribed mineralization pattern. © Eur J Oral Sci, 2006.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EOSen_US
dc.relation.ispartofEuropean Journal of Oral Sciencesen_US
dc.subject.meshCalcification, Physiologic - Drug Effectsen_US
dc.subject.meshCementogenesis - Drug Effectsen_US
dc.subject.meshDental Cementum - Drug Effects - Ultrastructureen_US
dc.subject.meshDental Enamel Proteins - Therapeutic Useen_US
dc.subject.meshGuided Tissue Regeneration, Periodontal - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIntegrin-Binding Sialoproteinen_US
dc.subject.meshMicroscopy, Electron, Transmissionen_US
dc.subject.meshOsteogenesis - Drug Effectsen_US
dc.subject.meshOsteopontinen_US
dc.subject.meshPeriodontal Ligament - Drug Effectsen_US
dc.subject.meshPeriodontitis - Therapyen_US
dc.subject.meshPhosphoproteins - Analysisen_US
dc.subject.meshSialoglycoproteins - Analysisen_US
dc.subject.meshTooth Root - Drug Effects - Ultrastructureen_US
dc.titlePattern of mineralization after regenerative periodontal therapy with enamel matrix proteinsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0722.2006.00300.xen_US
dc.identifier.pmid16674690en_US
dc.identifier.scopuseid_2-s2.0-33646512798en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646512798&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume114en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spage225en_US
dc.identifier.epage231en_US
dc.identifier.isiWOS:000240404800038-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridBosshardt, DD=6603806230en_US
dc.identifier.scopusauthoridSculean, A=7005695622en_US
dc.identifier.scopusauthoridDonos, N=7004314492en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US

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