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Conference Paper: Host response modulation in the management of periodontal diseases

TitleHost response modulation in the management of periodontal diseases
Authors
Issue Date2005
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2005, v. 32 SUPPL. 6, p. 108-129 How to Cite?
AbstractObjective: To review the biological mechanisms and clinical utility of therapeutic modulation of the host response in the management of periodontal diseases. Material and methods: A search of MEDLINE-PubMed was performed up to and including December 2004. The search was limited to in vitro, experimental animal and clinical studies published in English. The selection criteria included all levels of available evidence: systematic reviews, randomised-controlled clinical trials, controlled clinical trials, prospective and retrospective cohort studies and case reports of human and experimental animal studies. Results: Six targets for non-microbial chemotherapeutic intervention were identified. Clinical trials have demonstrated the ability of non-steroidal anti-inflammatory drugs to slow periodontal disease progression. However, recently reported serious adverse effects preclude the use of cyclooxygenase-2 inhibitors as an adjunct to periodontal therapy. Adjunctive use of subantimicrobial dose doxycycline to non-surgical periodontal therapy is beneficial in the management of chronic periodontitis over 12 months. Controversial data exist on the effects of bisphosphonate administration as an adjunct to periodontal therapy. Evidence on modulation of other host mediators including lipoxins, cytokines and nitric oxide synthase is limited to animal research. Conclusion: After validation in long-term clinical trials, adjunctive host modulation therapy may prove advantageous in the management of periodontal diseases. © Blackwell Munksgaard 2005.
Persistent Identifierhttp://hdl.handle.net/10722/157951
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSalvi, GEen_US
dc.contributor.authorLang, NPen_US
dc.date.accessioned2012-08-08T08:57:08Z-
dc.date.available2012-08-08T08:57:08Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Clinical Periodontology, 2005, v. 32 SUPPL. 6, p. 108-129en_US
dc.identifier.issn0303-6979en_US
dc.identifier.urihttp://hdl.handle.net/10722/157951-
dc.description.abstractObjective: To review the biological mechanisms and clinical utility of therapeutic modulation of the host response in the management of periodontal diseases. Material and methods: A search of MEDLINE-PubMed was performed up to and including December 2004. The search was limited to in vitro, experimental animal and clinical studies published in English. The selection criteria included all levels of available evidence: systematic reviews, randomised-controlled clinical trials, controlled clinical trials, prospective and retrospective cohort studies and case reports of human and experimental animal studies. Results: Six targets for non-microbial chemotherapeutic intervention were identified. Clinical trials have demonstrated the ability of non-steroidal anti-inflammatory drugs to slow periodontal disease progression. However, recently reported serious adverse effects preclude the use of cyclooxygenase-2 inhibitors as an adjunct to periodontal therapy. Adjunctive use of subantimicrobial dose doxycycline to non-surgical periodontal therapy is beneficial in the management of chronic periodontitis over 12 months. Controversial data exist on the effects of bisphosphonate administration as an adjunct to periodontal therapy. Evidence on modulation of other host mediators including lipoxins, cytokines and nitric oxide synthase is limited to animal research. Conclusion: After validation in long-term clinical trials, adjunctive host modulation therapy may prove advantageous in the management of periodontal diseases. © Blackwell Munksgaard 2005.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_US
dc.relation.ispartofJournal of Clinical Periodontologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Therapeutic Useen_US
dc.subject.meshArachidonic Acid - Antagonists & Inhibitorsen_US
dc.subject.meshBone Remodeling - Drug Effectsen_US
dc.subject.meshCyclooxygenase Inhibitors - Therapeutic Useen_US
dc.subject.meshDental Scalingen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation Mediators - Therapeutic Useen_US
dc.subject.meshLipoxins - Physiologyen_US
dc.subject.meshMatrix Metalloproteinases - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshNitric Oxide Synthase - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshPeriodontitis - Drug Therapy - Metabolismen_US
dc.subject.meshProtease Inhibitors - Pharmacology - Therapeutic Useen_US
dc.subject.meshReceptors, Cytokine - Drug Effectsen_US
dc.titleHost response modulation in the management of periodontal diseasesen_US
dc.typeConference_Paperen_US
dc.identifier.emailLang, NP:nplang@hkucc.hku.hken_US
dc.identifier.authorityLang, NP=rp00031en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-051X.2005.00785.xen_US
dc.identifier.pmid16128833-
dc.identifier.scopuseid_2-s2.0-25844460542en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-25844460542&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issueSUPPL. 6en_US
dc.identifier.spage108en_US
dc.identifier.epage129en_US
dc.identifier.isiWOS:000232374300010-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridSalvi, GE=35600695300en_US
dc.identifier.scopusauthoridLang, NP=7201577367en_US
dc.identifier.citeulike912862-

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