File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: High mortality associated with Catabacter hongkongensis bacteremia
  • Basic View
  • Metadata View
  • XML View
TitleHigh mortality associated with Catabacter hongkongensis bacteremia
 
AuthorsLau, SKP1
Fan, RYY1
Lo, HW1
Ng, RHY4
Wong, SSY1
Li, IWS1
Wu, AKL3
Ng, KHL2
Tseung, S4
Lee, RA3
Fung, KSC4
Que, TL2
Yuen, KY1
Woo, PCY1
 
KeywordsAcute cholecystitis
Antibiotic resistance
Appendectomy
Appendix perforation
Bacterium culture
 
Issue Date2012
 
PublisherAmerican Society for Microbiology.
 
CitationJournal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.00128-12
 
AbstractCatabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.
 
ISSN0095-1137
2013 Impact Factor: 4.232
 
DOIhttp://dx.doi.org/10.1128/JCM.00128-12
 
PubMed Central IDPMC3405600
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLau, SKP
 
dc.contributor.authorFan, RYY
 
dc.contributor.authorLo, HW
 
dc.contributor.authorNg, RHY
 
dc.contributor.authorWong, SSY
 
dc.contributor.authorLi, IWS
 
dc.contributor.authorWu, AKL
 
dc.contributor.authorNg, KHL
 
dc.contributor.authorTseung, S
 
dc.contributor.authorLee, RA
 
dc.contributor.authorFung, KSC
 
dc.contributor.authorQue, TL
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorWoo, PCY
 
dc.date.accessioned2012-08-08T08:52:28Z
 
dc.date.available2012-08-08T08:52:28Z
 
dc.date.issued2012
 
dc.description.abstractCatabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.00128-12
 
dc.identifier.doihttp://dx.doi.org/10.1128/JCM.00128-12
 
dc.identifier.epage2243
 
dc.identifier.hkuros204376
 
dc.identifier.issn0095-1137
2013 Impact Factor: 4.232
 
dc.identifier.issue7
 
dc.identifier.pmcidPMC3405600
 
dc.identifier.pmid22518872
 
dc.identifier.scopuseid_2-s2.0-84862731799
 
dc.identifier.spage2239
 
dc.identifier.urihttp://hdl.handle.net/10722/157709
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology.
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Microbiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.
 
dc.rightsCopyright © American Society for Microbiology, [Journal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243]
 
dc.subjectAcute cholecystitis
 
dc.subjectAntibiotic resistance
 
dc.subjectAppendectomy
 
dc.subjectAppendix perforation
 
dc.subjectBacterium culture
 
dc.titleHigh mortality associated with Catabacter hongkongensis bacteremia
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Lau, SKP</contributor.author>
<contributor.author>Fan, RYY</contributor.author>
<contributor.author>Lo, HW</contributor.author>
<contributor.author>Ng, RHY</contributor.author>
<contributor.author>Wong, SSY</contributor.author>
<contributor.author>Li, IWS</contributor.author>
<contributor.author>Wu, AKL</contributor.author>
<contributor.author>Ng, KHL</contributor.author>
<contributor.author>Tseung, S</contributor.author>
<contributor.author>Lee, RA</contributor.author>
<contributor.author>Fung, KSC</contributor.author>
<contributor.author>Que, TL</contributor.author>
<contributor.author>Yuen, KY</contributor.author>
<contributor.author>Woo, PCY</contributor.author>
<date.accessioned>2012-08-08T08:52:28Z</date.accessioned>
<date.available>2012-08-08T08:52:28Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Journal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243</identifier.citation>
<identifier.issn>0095-1137</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/157709</identifier.uri>
<description.abstract>Catabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.</description.abstract>
<language>eng</language>
<publisher>American Society for Microbiology.</publisher>
<relation.ispartof>Journal of Clinical Microbiology</relation.ispartof>
<rights>Journal of Clinical Microbiology. Copyright &#169; American Society for Microbiology.</rights>
<rights>Copyright &#169; American Society for Microbiology, [Journal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243]</rights>
<subject>Acute cholecystitis</subject>
<subject>Antibiotic resistance</subject>
<subject>Appendectomy</subject>
<subject>Appendix perforation</subject>
<subject>Bacterium culture</subject>
<title>High mortality associated with Catabacter hongkongensis bacteremia</title>
<type>Article</type>
<description.nature>link_to_OA_fulltext</description.nature>
<identifier.doi>10.1128/JCM.00128-12</identifier.doi>
<identifier.pmid>22518872</identifier.pmid>
<identifier.pmcid>PMC3405600</identifier.pmcid>
<identifier.scopus>eid_2-s2.0-84862731799</identifier.scopus>
<identifier.hkuros>204376</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862731799&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>50</identifier.volume>
<identifier.issue>7</identifier.issue>
<identifier.spage>2239</identifier.spage>
<identifier.epage>2243</identifier.epage>
<publisher.place>United States</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/157709/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Tuen Mun Hospital
  3. Pamela Youde Nethersole Eastern Hospital
  4. United Christian Hospital Hong Kong