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Article: High mortality associated with Catabacter hongkongensis bacteremia

TitleHigh mortality associated with Catabacter hongkongensis bacteremia
Authors
KeywordsAcute cholecystitis
Antibiotic resistance
Appendectomy
Appendix perforation
Bacterium culture
Issue Date2012
PublisherAmerican Society for Microbiology.
Citation
Journal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243 How to Cite?
AbstractCatabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/157709
ISSN
2014 Impact Factor: 3.993
2014 SCImago Journal Rankings: 1.893
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, SKPen_US
dc.contributor.authorFan, RYYen_US
dc.contributor.authorLo, HWen_US
dc.contributor.authorNg, RHYen_US
dc.contributor.authorWong, SSYen_US
dc.contributor.authorLi, IWSen_US
dc.contributor.authorWu, AKLen_US
dc.contributor.authorNg, KHLen_US
dc.contributor.authorTseung, Sen_US
dc.contributor.authorLee, RAen_US
dc.contributor.authorFung, KSCen_US
dc.contributor.authorQue, TLen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorWoo, PCYen_US
dc.date.accessioned2012-08-08T08:52:28Z-
dc.date.available2012-08-08T08:52:28Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243en_US
dc.identifier.issn0095-1137en_US
dc.identifier.urihttp://hdl.handle.net/10722/157709-
dc.description.abstractCatabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology.-
dc.relation.ispartofJournal of Clinical Microbiologyen_US
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [Journal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243]-
dc.subjectAcute cholecystitis-
dc.subjectAntibiotic resistance-
dc.subjectAppendectomy-
dc.subjectAppendix perforation-
dc.subjectBacterium culture-
dc.titleHigh mortality associated with Catabacter hongkongensis bacteremiaen_US
dc.typeArticleen_US
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hken_US
dc.identifier.emailFan, RYY: rfyy@hku.hken_US
dc.identifier.emailWong, SSY: samsonsy@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLau, SKP=rp00486en_US
dc.identifier.authorityWoo, PCY=rp00430en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JCM.00128-12en_US
dc.identifier.pmid22518872-
dc.identifier.pmcidPMC3405600-
dc.identifier.scopuseid_2-s2.0-84862731799en_US
dc.identifier.hkuros204376-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862731799&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue7en_US
dc.identifier.spage2239en_US
dc.identifier.epage2243en_US
dc.identifier.isiWOS:000307360800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWoo, PCY=7201801340en_US
dc.identifier.scopusauthoridYuen, KY=55018434500en_US
dc.identifier.scopusauthoridQue, TL=7003786628en_US
dc.identifier.scopusauthoridFung, KSC=55259963600en_US
dc.identifier.scopusauthoridLee, RA=55259790500en_US
dc.identifier.scopusauthoridTseung, S=55260248300en_US
dc.identifier.scopusauthoridNg, KHL=27467782600en_US
dc.identifier.scopusauthoridWu, AKL=55247482100en_US
dc.identifier.scopusauthoridLi, IWS=55259870500en_US
dc.identifier.scopusauthoridWong, SSY=55259895800en_US
dc.identifier.scopusauthoridNg, RHY=55260408500en_US
dc.identifier.scopusauthoridLo, HW=55259853200en_US
dc.identifier.scopusauthoridFan, RYY=15519269300en_US
dc.identifier.scopusauthoridLau, SKP=7401596211en_US

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