Article: High mortality associated with Catabacter hongkongensis bacteremia

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TitleHigh mortality associated with Catabacter hongkongensis bacteremia
AuthorsLau, SKP2
Fan, RYY2
Lo, HW2
Ng, RHY4
Wong, SSY2
Li, IWS2
Wu, AKL3
Ng, KHL1
Tseung, S4
Lee, RA3
Fung, KSC4
Que, TL1
Yuen, KY2
Woo, PCY2
KeywordsAcute cholecystitis
Antibiotic resistance
Appendectomy
Appendix perforation
Bacterium culture
Issue Date2012
PublisherAmerican Society for Microbiology.
CitationJournal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.00128-12
AbstractCatabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.
ISSN0095-1137
2011 Impact Factor: 4.153
2011 SCImago Journal Rankings: 0.397
DOIhttp://dx.doi.org/10.1128/JCM.00128-12
PubMed Central IDPMC3405600
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLau, SKP
dc.contributor.authorFan, RYY
dc.contributor.authorLo, HW
dc.contributor.authorNg, RHY
dc.contributor.authorWong, SSY
dc.contributor.authorLi, IWS
dc.contributor.authorWu, AKL
dc.contributor.authorNg, KHL
dc.contributor.authorTseung, S
dc.contributor.authorLee, RA
dc.contributor.authorFung, KSC
dc.contributor.authorQue, TL
dc.contributor.authorYuen, KY
dc.contributor.authorWoo, PCY
dc.date.accessioned2012-08-08T08:52:28Z
dc.date.available2012-08-08T08:52:28Z
dc.date.issued2012
dc.description.abstractCatabacter hongkongensis is a recently described catalase-positive, motile, anaerobic, nonsporulating, Gram-positive coccobacillus that was first isolated from blood cultures of four patients from Hong Kong and Canada. Although DNA sequences representing C. hongkongensis have been detected in environmental sources, only one additional case of human infection has been reported, in France. We describe five cases of C. hongkongensis bacteremia in Hong Kong, two presenting with sepsis, one with acute gangrenous perforated appendicitis, one with acute calculous cholecystitis, and one with infected carcinoma of colon. Three patients, with gastrointestinal malignancy, died during admission. All five isolates were catalase positive, motile, and negative for indole production and nitrate reduction and produced acid from arabinose, glucose, mannose, and xylose. They were unambiguously identified as C. hongkongensis by 16S rRNA gene analysis. Of the total of 10 reported cases of C. hongkongensis bacteremia in the literature and this study, most patients had underlying diseases, while two cases occurred in healthy young individuals with acute appendicitis. Six patients presented with infections associated with either the gastrointestinal or biliary tract, supporting the gastrointestinal tract as the source of bacteremia. C. hongkongensis bacteremia is associated with a poor prognosis, with a high mortality of 50% among reported cases, especially in patients with advanced malignancies. All reported isolates were susceptible to metronidazole. Identification of more C. hongkongensis isolates by 16S rRNA gene sequencing will help better define its epidemiology and pathogenesis.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationJournal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.00128-12
dc.identifier.doihttp://dx.doi.org/10.1128/JCM.00128-12
dc.identifier.epage2243
dc.identifier.hkuros204376
dc.identifier.issn0095-1137
2011 Impact Factor: 4.153
2011 SCImago Journal Rankings: 0.397
dc.identifier.issue7
dc.identifier.pmcidPMC3405600
dc.identifier.pmid22518872
dc.identifier.scopuseid_2-s2.0-84862731799
dc.identifier.spage2239
dc.identifier.urihttp://hdl.handle.net/10722/157709
dc.identifier.volume50
dc.languageeng
dc.publisherAmerican Society for Microbiology.
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Clinical Microbiology
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.
dc.rightsCopyright © American Society for Microbiology, [Journal of Clinical Microbiology, 2012, v. 50 n. 7, p. 2239-2243]
dc.subjectAcute cholecystitis
dc.subjectAntibiotic resistance
dc.subjectAppendectomy
dc.subjectAppendix perforation
dc.subjectBacterium culture
dc.titleHigh mortality associated with Catabacter hongkongensis bacteremia
dc.typeArticle
Author Affiliations
  1. Tuen Mun Hospital
  2. The University of Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. United Christian Hospital Hong Kong