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Article: Wild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses.

TitleWild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses.
Authors
Issue Date2012
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2012, v. 18 Suppl 2, p. 25-26 How to Cite?
Abstract1. Although CoV-HKU1 was not identified in any of the studied animals, a coronavirus closely related to SARS-CoV (bat-SARS-CoV) was identified in 23 (19%) of 118 wild Chinese horseshoe bats by reverse transcriptase polymerase chain reaction (RT-PCR). 2. Complete genome sequencing and phylogenetic analysis showed that bat-SARS-CoV formed a distinct cluster with SARS-CoV as group 2b coronaviruses, distantly related to known group 2 coronaviruses. 3. Most differences between the bat-SARS-CoV and SARS-CoV genomes were observed in the spike gene. The presence of a29-bp insertion in ORF 8 of bat-SARS-CoV genome, not in most human SARS-CoV genomes, suggests that it has a common ancestor with civet SARS-CoV. 4. Antibody against recombinant bat-SARS-CoV nucleocapsid protein was detected in 84% of Chinese horseshoe bats using an enzyme immunoassay.Neutralising antibody to human SARS-CoV was also detected in those with lower viral loads.5. This study also revealed a previously unknown diversity of coronaviruses in bats, which are important natural reservoir for coronaviruses including SARS-CoV-like viruses.
Persistent Identifierhttp://hdl.handle.net/10722/157702
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorYuen, KYen_US
dc.contributor.authorLau, SKen_US
dc.contributor.authorWoo, PCen_US
dc.date.accessioned2012-08-08T08:52:24Z-
dc.date.available2012-08-08T08:52:24Z-
dc.date.issued2012en_US
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2012, v. 18 Suppl 2, p. 25-26en_US
dc.identifier.issn1024-2708en_US
dc.identifier.urihttp://hdl.handle.net/10722/157702-
dc.description.abstract1. Although CoV-HKU1 was not identified in any of the studied animals, a coronavirus closely related to SARS-CoV (bat-SARS-CoV) was identified in 23 (19%) of 118 wild Chinese horseshoe bats by reverse transcriptase polymerase chain reaction (RT-PCR). 2. Complete genome sequencing and phylogenetic analysis showed that bat-SARS-CoV formed a distinct cluster with SARS-CoV as group 2b coronaviruses, distantly related to known group 2 coronaviruses. 3. Most differences between the bat-SARS-CoV and SARS-CoV genomes were observed in the spike gene. The presence of a29-bp insertion in ORF 8 of bat-SARS-CoV genome, not in most human SARS-CoV genomes, suggests that it has a common ancestor with civet SARS-CoV. 4. Antibody against recombinant bat-SARS-CoV nucleocapsid protein was detected in 84% of Chinese horseshoe bats using an enzyme immunoassay.Neutralising antibody to human SARS-CoV was also detected in those with lower viral loads.5. This study also revealed a previously unknown diversity of coronaviruses in bats, which are important natural reservoir for coronaviruses including SARS-CoV-like viruses.en_US
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_US
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChiroptera - Virologyen_US
dc.subject.meshCoronavirus - Genetics - Isolation & Purificationen_US
dc.subject.meshDisease Reservoirsen_US
dc.subject.meshGenes, Polen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMacaca Mulatta - Virologyen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshRodentia - Virologyen_US
dc.subject.meshSars Virus - Genetics - Isolation & Purificationen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.titleWild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses.en_US
dc.typeArticleen_US
dc.identifier.emailLau, SK:skplau@hkucc.hku.hken_US
dc.identifier.authorityLau, SK=rp00486en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid22311357-
dc.identifier.scopuseid_2-s2.0-84861556689en_US
dc.identifier.volume18 Suppl 2en_US
dc.identifier.spage25en_US
dc.identifier.epage26en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridYuen, KY=55042448400en_US
dc.identifier.scopusauthoridLau, SK=7401596211en_US
dc.identifier.scopusauthoridWoo, PC=55232918300en_US

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