File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
  • Basic View
  • Metadata View
  • XML View
TitleMolecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
 
AuthorsHo, PL1
Chiu, SS1
Chan, MY1
Gan, Y1
Chow, KH1
Lai, EL1
Lau, YL1
 
Issue Date2012
 
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
 
CitationJournal of Infection, 2012, v. 64 n. 5, p. 500-506 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jinf.2012.02.018
 
AbstractOBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population.
 
ISSN0163-4453
2012 Impact Factor: 4.073
2012 SCImago Journal Rankings: 1.489
 
DOIhttp://dx.doi.org/10.1016/j.jinf.2012.02.018
 
ISI Accession Number IDWOS:000303000400005
Funding AgencyGrant Number
Health and Food Bureau of the Hong Kong SAR Government
Funding Information:

The work is supported by a research grant from the Research Fund for the Control of Infectious Diseases (RFCID) of the Health and Food Bureau of the Hong Kong SAR Government.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorChiu, SS
 
dc.contributor.authorChan, MY
 
dc.contributor.authorGan, Y
 
dc.contributor.authorChow, KH
 
dc.contributor.authorLai, EL
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2012-08-08T08:52:16Z
 
dc.date.available2012-08-08T08:52:16Z
 
dc.date.issued2012
 
dc.description.abstractOBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population.
 
dc.description.naturepostprint
 
dc.identifier.citationJournal of Infection, 2012, v. 64 n. 5, p. 500-506 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jinf.2012.02.018
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jinf.2012.02.018
 
dc.identifier.epage506
 
dc.identifier.hkuros200716
 
dc.identifier.isiWOS:000303000400005
Funding AgencyGrant Number
Health and Food Bureau of the Hong Kong SAR Government
Funding Information:

The work is supported by a research grant from the Research Fund for the Control of Infectious Diseases (RFCID) of the Health and Food Bureau of the Hong Kong SAR Government.

 
dc.identifier.issn0163-4453
2012 Impact Factor: 4.073
2012 SCImago Journal Rankings: 1.489
 
dc.identifier.issue5
 
dc.identifier.pmid22406412
 
dc.identifier.scopuseid_2-s2.0-84859838790
 
dc.identifier.spage500
 
dc.identifier.urihttp://hdl.handle.net/10722/157689
 
dc.identifier.volume64
 
dc.languageeng
 
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Infection
 
dc.relation.referencesReferences in Scopus
 
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection, 2012, v. 64 n. 5, p. 500-506. DOI: 10.1016/j.jinf.2012.02.018
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCarrier State - epidemiology - microbiology
 
dc.subject.meshChild Day Care Centers
 
dc.subject.meshMethicillin-Resistant Staphylococcus aureus - classification - drug effects - genetics - isolation and purification
 
dc.subject.meshNose - microbiology
 
dc.subject.meshStaphylococcal Infections - epidemiology - microbiology
 
dc.titleMolecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Ho, PL</contributor.author>
<contributor.author>Chiu, SS</contributor.author>
<contributor.author>Chan, MY</contributor.author>
<contributor.author>Gan, Y</contributor.author>
<contributor.author>Chow, KH</contributor.author>
<contributor.author>Lai, EL</contributor.author>
<contributor.author>Lau, YL</contributor.author>
<date.accessioned>2012-08-08T08:52:16Z</date.accessioned>
<date.available>2012-08-08T08:52:16Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Journal of Infection, 2012, v. 64 n. 5, p. 500-506</identifier.citation>
<identifier.issn>0163-4453</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/157689</identifier.uri>
<description.abstract>OBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population.</description.abstract>
<language>eng</language>
<publisher>WB Saunders Co Ltd. The Journal&apos;s web site is located at http://www.elsevier.com/locate/jinf</publisher>
<relation.ispartof>Journal of Infection</relation.ispartof>
<rights>NOTICE: this is the author&#8217;s version of a work that was accepted for publication in Journal of Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection, 2012, v. 64 n. 5, p. 500-506. DOI: 10.1016/j.jinf.2012.02.018</rights>
<rights>Creative Commons: Attribution 3.0 Hong Kong License</rights>
<subject.mesh>Carrier State - epidemiology - microbiology</subject.mesh>
<subject.mesh>Child Day Care Centers</subject.mesh>
<subject.mesh>Methicillin-Resistant Staphylococcus aureus - classification - drug effects - genetics - isolation and purification</subject.mesh>
<subject.mesh>Nose - microbiology</subject.mesh>
<subject.mesh>Staphylococcal Infections - epidemiology - microbiology</subject.mesh>
<title>Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong</title>
<type>Article</type>
<description.nature>postprint</description.nature>
<identifier.doi>10.1016/j.jinf.2012.02.018</identifier.doi>
<identifier.pmid>22406412</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84859838790</identifier.scopus>
<identifier.hkuros>200716</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-84859838790&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>64</identifier.volume>
<identifier.issue>5</identifier.issue>
<identifier.spage>500</identifier.spage>
<identifier.epage>506</identifier.epage>
<identifier.isi>WOS:000303000400005</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<bitstream.url>http://hub.hku.hk/bitstream/10722/157689/1/Content.pdf</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong