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Article: Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong

TitleMolecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong
Authors
Issue Date2012
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal of Infection, 2012, v. 64 n. 5, p. 500-506 How to Cite?
Abstract
OBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population.
Persistent Identifierhttp://hdl.handle.net/10722/157689
ISSN
2013 Impact Factor: 4.017
2013 SCImago Journal Rankings: 1.738
ISI Accession Number ID
Funding AgencyGrant Number
Health and Food Bureau of the Hong Kong SAR Government
Funding Information:

The work is supported by a research grant from the Research Fund for the Control of Infectious Diseases (RFCID) of the Health and Food Bureau of the Hong Kong SAR Government.

References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorChan, MYen_HK
dc.contributor.authorGan, Yen_HK
dc.contributor.authorChow, KHen_HK
dc.contributor.authorLai, ELen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2012-08-08T08:52:16Z-
dc.date.available2012-08-08T08:52:16Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of Infection, 2012, v. 64 n. 5, p. 500-506en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157689-
dc.description.abstractOBJECTIVES: To investigate the prevalence and molecular epidemiology of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) nasal carriage in children. METHODS: We collected nasal and nasopharyngeal swabs from 2211 children aged 2-5 years attending 79 day care centers (DCCs) and 113 kindergartens (KGs) in all 18 geographical districts in Hong Kong. RESULTS: The overall carriage rates of S. aureus and MRSA were 27.6% (95% confidence interval [CI], 24.8-28.5%) and 1.3% (95% CI, 0.8-1.8%), respectively. Molecular typing (staphylococcal cassette chromosome mec [SCCmec], sequence type [ST], clonal cluster [CC]) showed that all the 28 MRSA isolates had SCCmec IV (n = 13) or V (n = 15) including 12 isolates with community-associated-MRSA genotypes (ST59-IV/V, ST30-IV and ST88-V), 10 isolates with healthcare-associated-MRSA genotypes (ST45-IV/V, CC5-IV and ST630-V) and six isolates with novel genotypes (ST10-V and CC1-IV). Spa typing indicated that there was some within and between DCCs/KGs transmission of certain MRSA and methicillin-sensitive S. aureus strains but this was not extensive. CONCLUSION: Our findings indicate the potential for DCCs to be a reservoir for emerging MRSA genotypes and highlight the need to enhance education and infection control measures to reduce their cross-transmission in this population.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Infection. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Infection, 2012, v. 64 n. 5, p. 500-506. DOI: 10.1016/j.jinf.2012.02.018-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarrier State - epidemiology - microbiology-
dc.subject.meshChild Day Care Centers-
dc.subject.meshMethicillin-Resistant Staphylococcus aureus - classification - drug effects - genetics - isolation and purification-
dc.subject.meshNose - microbiology-
dc.subject.meshStaphylococcal Infections - epidemiology - microbiology-
dc.titleMolecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailChiu, SS: ssschiu@hku.hken_HK
dc.identifier.emailChow, KH: khchowb@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityChow, KH=rp00370en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepostprinten_US
dc.identifier.doi10.1016/j.jinf.2012.02.018en_HK
dc.identifier.pmid22406412-
dc.identifier.scopuseid_2-s2.0-84859838790en_HK
dc.identifier.hkuros200716-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859838790&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue5en_HK
dc.identifier.spage500en_HK
dc.identifier.epage506en_HK
dc.identifier.isiWOS:000303000400005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridLai, EL=55081620700en_HK
dc.identifier.scopusauthoridChow, KH=7202180736en_HK
dc.identifier.scopusauthoridGan, Y=55082076700en_HK
dc.identifier.scopusauthoridChan, MY=37109508300en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK

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