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Article: Brittle tail syndrome is an emerging infection in horses caused by a keratinolytic fungus Equicapillimyces hongkongensis gen. nov., sp. nov
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TitleBrittle tail syndrome is an emerging infection in horses caused by a keratinolytic fungus Equicapillimyces hongkongensis gen. nov., sp. nov
 
AuthorsWong, SSY2
Ngan, AHY2
Riggs, CM
Teng, JLL2
Choi, GKY2
Poon, RWS2
Hui, JJY1
Low, FJ
Luk, A
Yuen, KY2
 
KeywordsDermatophyte
Horses
Keratinolytic
 
Issue Date2012
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/vetmic
 
CitationVeterinary Microbiology, 2012, v. 155 n. 2-4, p. 399-408 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.vetmic.2011.09.024
 
AbstractThe newly described brittle tail syndrome causes weakening and breakage of the tail hair of horses. Extensive mycological and molecular studies showed that a novel fungus Equicapillimyces hongkongensis gen. nov., sp. nov. is the most likely cause of this syndrome. It is a septate branching hyaline mould which grows optimally at 30 °C, requires nicotinic acid but is inhibited by cycloheximide, and specifically infects horse hair. Hyphae fill the core of infected hair shafts with short-necked structures resembling ascomata containing banana-shaped septate ascospore-like structures perforating the hair cortex from within. Compared to asymptomatic horses (n= 31), horses with clinical signs of the syndrome (n= 22) are significantly more likely to have positive E. hongkongensis gen. nov., sp. nov. smear (6.5% vs. 100%), culture (6.5% vs. 72.7%), and PCR (32.3% vs. 100%, P< 0.001 for all). No other potential pathogens were found on bacteriological and mycological culture or PCR (for Trichophyton, Microsporum and Epidermophyton). Genotyping of pure E. hongkongensis gen. nov., sp. nov. isolates and their corresponding direct specimens by PCR and sequencing of the 18S rRNA, ITS1-5.8S-ITS2, 28S rRNA, beta-actin, beta-tubulin, and elongation factor 1 alpha showed that they are all identical but unique, and related distantly to fungi mostly in the class Sordariomycetes and the family Ophiostomataceae. Its geographical distribution, environmental or animal reservoirs are still unknown. Besides the ugly appearance of infected horse tails, this fungus may emerge as another equine pathogen if it affects the skin and hoof of horses. © 2011 Elsevier B.V.
 
ISSN0378-1135
2012 Impact Factor: 3.127
2012 SCImago Journal Rankings: 1.221
 
DOIhttp://dx.doi.org/10.1016/j.vetmic.2011.09.024
 
ISI Accession Number IDWOS:000301626800038
Funding AgencyGrant Number
Hong Kong Jockey Club
Department of Microbiology, Queen Mary Hospital
Ted Sun Foundation
Food and Health Bureau of the Hong Kong Special Administrative Region, China
Funding Information:

We are most indebted to Mr Kam-Chu Han for his efforts in the preparation of the histology slides. The authors are grateful to the support from the staff of the Hong Kong Jockey Club and the Department of Microbiology, Queen Mary Hospital. The study is partially funded by the Ted Sun Foundation, the Clinical Infectious Diseases Research Endowment Fund from Ms. Teresa Wong On Yik, and the commissioned block grant of the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong Special Administrative Region, China.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, SSY
 
dc.contributor.authorNgan, AHY
 
dc.contributor.authorRiggs, CM
 
dc.contributor.authorTeng, JLL
 
dc.contributor.authorChoi, GKY
 
dc.contributor.authorPoon, RWS
 
dc.contributor.authorHui, JJY
 
dc.contributor.authorLow, FJ
 
dc.contributor.authorLuk, A
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2012-08-08T08:52:11Z
 
dc.date.available2012-08-08T08:52:11Z
 
dc.date.issued2012
 
dc.description.abstractThe newly described brittle tail syndrome causes weakening and breakage of the tail hair of horses. Extensive mycological and molecular studies showed that a novel fungus Equicapillimyces hongkongensis gen. nov., sp. nov. is the most likely cause of this syndrome. It is a septate branching hyaline mould which grows optimally at 30 °C, requires nicotinic acid but is inhibited by cycloheximide, and specifically infects horse hair. Hyphae fill the core of infected hair shafts with short-necked structures resembling ascomata containing banana-shaped septate ascospore-like structures perforating the hair cortex from within. Compared to asymptomatic horses (n= 31), horses with clinical signs of the syndrome (n= 22) are significantly more likely to have positive E. hongkongensis gen. nov., sp. nov. smear (6.5% vs. 100%), culture (6.5% vs. 72.7%), and PCR (32.3% vs. 100%, P< 0.001 for all). No other potential pathogens were found on bacteriological and mycological culture or PCR (for Trichophyton, Microsporum and Epidermophyton). Genotyping of pure E. hongkongensis gen. nov., sp. nov. isolates and their corresponding direct specimens by PCR and sequencing of the 18S rRNA, ITS1-5.8S-ITS2, 28S rRNA, beta-actin, beta-tubulin, and elongation factor 1 alpha showed that they are all identical but unique, and related distantly to fungi mostly in the class Sordariomycetes and the family Ophiostomataceae. Its geographical distribution, environmental or animal reservoirs are still unknown. Besides the ugly appearance of infected horse tails, this fungus may emerge as another equine pathogen if it affects the skin and hoof of horses. © 2011 Elsevier B.V.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationVeterinary Microbiology, 2012, v. 155 n. 2-4, p. 399-408 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.vetmic.2011.09.024
 
dc.identifier.citeulike9857023
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.vetmic.2011.09.024
 
dc.identifier.eissn1873-2542
 
dc.identifier.epage408
 
dc.identifier.isiWOS:000301626800038
Funding AgencyGrant Number
Hong Kong Jockey Club
Department of Microbiology, Queen Mary Hospital
Ted Sun Foundation
Food and Health Bureau of the Hong Kong Special Administrative Region, China
Funding Information:

We are most indebted to Mr Kam-Chu Han for his efforts in the preparation of the histology slides. The authors are grateful to the support from the staff of the Hong Kong Jockey Club and the Department of Microbiology, Queen Mary Hospital. The study is partially funded by the Ted Sun Foundation, the Clinical Infectious Diseases Research Endowment Fund from Ms. Teresa Wong On Yik, and the commissioned block grant of the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau of the Hong Kong Special Administrative Region, China.

 
dc.identifier.issn0378-1135
2012 Impact Factor: 3.127
2012 SCImago Journal Rankings: 1.221
 
dc.identifier.issue2-4
 
dc.identifier.scopuseid_2-s2.0-84857049808
 
dc.identifier.spage399
 
dc.identifier.urihttp://hdl.handle.net/10722/157678
 
dc.identifier.volume155
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/vetmic
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofVeterinary Microbiology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectDermatophyte
 
dc.subjectHorses
 
dc.subjectKeratinolytic
 
dc.titleBrittle tail syndrome is an emerging infection in horses caused by a keratinolytic fungus Equicapillimyces hongkongensis gen. nov., sp. nov
 
dc.typeArticle
 
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<description.abstract>The newly described brittle tail syndrome causes weakening and breakage of the tail hair of horses. Extensive mycological and molecular studies showed that a novel fungus Equicapillimyces hongkongensis gen. nov., sp. nov. is the most likely cause of this syndrome. It is a septate branching hyaline mould which grows optimally at 30 &#176;C, requires nicotinic acid but is inhibited by cycloheximide, and specifically infects horse hair. Hyphae fill the core of infected hair shafts with short-necked structures resembling ascomata containing banana-shaped septate ascospore-like structures perforating the hair cortex from within. Compared to asymptomatic horses (n= 31), horses with clinical signs of the syndrome (n= 22) are significantly more likely to have positive E. hongkongensis gen. nov., sp. nov. smear (6.5% vs. 100%), culture (6.5% vs. 72.7%), and PCR (32.3% vs. 100%, P&lt; 0.001 for all). No other potential pathogens were found on bacteriological and mycological culture or PCR (for Trichophyton, Microsporum and Epidermophyton). Genotyping of pure E. hongkongensis gen. nov., sp. nov. isolates and their corresponding direct specimens by PCR and sequencing of the 18S rRNA, ITS1-5.8S-ITS2, 28S rRNA, beta-actin, beta-tubulin, and elongation factor 1 alpha showed that they are all identical but unique, and related distantly to fungi mostly in the class Sordariomycetes and the family Ophiostomataceae. Its geographical distribution, environmental or animal reservoirs are still unknown. Besides the ugly appearance of infected horse tails, this fungus may emerge as another equine pathogen if it affects the skin and hoof of horses. &#169; 2011 Elsevier B.V.</description.abstract>
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Author Affiliations
  1. PathLab Medical Laboratories Ltd.
  2. The University of Hong Kong