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Article: The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics
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TitleThe emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics
 
AuthorsIwao, Y4
Ishii, R6
Tomita, Y2
Shibuya, Y1
Takano, T4
Hung, WC4
Higuchi, W4
Isobe, H4
Nishiyama, A4
Yano, M8
Matsumoto, T9
Ogata, K7
Okubo, T5
Khokhlova, O4
Ho, PL3
Yamamoto, T4
 
KeywordsCommunity-Acquired Methicillin-Resistant Staphylococcus Aureus (Ca-Mrsa)
Comparative Genomics
Diversity
Evolution
Infections
St8 Ca-Mrsa/J
Toxic Shock Syndrome Toxin-1 (Tsst-1)
 
Issue Date2012
 
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10156/index.htm
 
CitationJournal Of Infection And Chemotherapy, 2012, v. 18 n. 2, p. 228-240 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10156-012-0379-6
 
AbstractCommunity-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCC mecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCC mecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8 Jα to γ. Of those, ST8 Jβ was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine leukocidin phage and arginine catabolic mobile element, unlike USA300. The unique features of ST8 CA-MRSA/J included a novel mosaic SaPI (designated SaPIj50) carrying the toxic shock syndrome toxin-1 gene with high expression; the evolution included salvage (through recombination) of hospital-acquired MRSA virulence. The data suggest that ST8 CA-MRSA/J has become a successful native clone in Japan, in association with not only SSTIs but also severe invasive infections (posing a threat), requiring attention. © 2012 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
 
ISSN1341-321X
2012 Impact Factor: 1.554
2012 SCImago Journal Rankings: 0.628
 
DOIhttp://dx.doi.org/10.1007/s10156-012-0379-6
 
ISI Accession Number IDWOS:000303057800012
 
DC FieldValue
dc.contributor.authorIwao, Y
 
dc.contributor.authorIshii, R
 
dc.contributor.authorTomita, Y
 
dc.contributor.authorShibuya, Y
 
dc.contributor.authorTakano, T
 
dc.contributor.authorHung, WC
 
dc.contributor.authorHiguchi, W
 
dc.contributor.authorIsobe, H
 
dc.contributor.authorNishiyama, A
 
dc.contributor.authorYano, M
 
dc.contributor.authorMatsumoto, T
 
dc.contributor.authorOgata, K
 
dc.contributor.authorOkubo, T
 
dc.contributor.authorKhokhlova, O
 
dc.contributor.authorHo, PL
 
dc.contributor.authorYamamoto, T
 
dc.date.accessioned2012-08-08T08:52:10Z
 
dc.date.available2012-08-08T08:52:10Z
 
dc.date.issued2012
 
dc.description.abstractCommunity-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCC mecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCC mecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8 Jα to γ. Of those, ST8 Jβ was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine leukocidin phage and arginine catabolic mobile element, unlike USA300. The unique features of ST8 CA-MRSA/J included a novel mosaic SaPI (designated SaPIj50) carrying the toxic shock syndrome toxin-1 gene with high expression; the evolution included salvage (through recombination) of hospital-acquired MRSA virulence. The data suggest that ST8 CA-MRSA/J has become a successful native clone in Japan, in association with not only SSTIs but also severe invasive infections (posing a threat), requiring attention. © 2012 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Infection And Chemotherapy, 2012, v. 18 n. 2, p. 228-240 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s10156-012-0379-6
 
dc.identifier.citeulike10395880
 
dc.identifier.doihttp://dx.doi.org/10.1007/s10156-012-0379-6
 
dc.identifier.epage240
 
dc.identifier.hkuros209787
 
dc.identifier.isiWOS:000303057800012
 
dc.identifier.issn1341-321X
2012 Impact Factor: 1.554
2012 SCImago Journal Rankings: 0.628
 
dc.identifier.issue2
 
dc.identifier.pmid22350401
 
dc.identifier.scopuseid_2-s2.0-84863318559
 
dc.identifier.spage228
 
dc.identifier.urihttp://hdl.handle.net/10722/157677
 
dc.languageeng
 
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10156/index.htm
 
dc.publisher.placeJapan
 
dc.relation.ispartofJournal of Infection and Chemotherapy
 
dc.subjectCommunity-Acquired Methicillin-Resistant Staphylococcus Aureus (Ca-Mrsa)
 
dc.subjectComparative Genomics
 
dc.subjectDiversity
 
dc.subjectEvolution
 
dc.subjectInfections
 
dc.subjectSt8 Ca-Mrsa/J
 
dc.subjectToxic Shock Syndrome Toxin-1 (Tsst-1)
 
dc.titleThe emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics
 
dc.typeArticle
 
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<contributor.author>Hung, WC</contributor.author>
<contributor.author>Higuchi, W</contributor.author>
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<description.abstract>Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCC mecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCC mecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8&#160;J&#945; to &#947;. Of those, ST8&#160;J&#946; was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine leukocidin phage and arginine catabolic mobile element, unlike USA300. The unique features of ST8 CA-MRSA/J included a novel mosaic SaPI (designated SaPIj50) carrying the toxic shock syndrome toxin-1 gene with high expression; the evolution included salvage (through recombination) of hospital-acquired MRSA virulence. The data suggest that ST8 CA-MRSA/J has become a successful native clone in Japan, in association with not only SSTIs but also severe invasive infections (posing a threat), requiring attention. &#169; 2012 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.</description.abstract>
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Author Affiliations
  1. Tokyo Metropolitan Bokuto General Hospital
  2. Kumamoto University
  3. The University of Hong Kong
  4. Niigata University School of Medicine
  5. Niigata Prefectural Muikamachi Hospital
  6. Akashi Municipal Hospital
  7. Oita Prefectural Institute of Public Health and Environmental Science
  8. Kyoto Prefectural University of Medicine
  9. Tokyo Medical University