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Article: The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics

TitleThe emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics
Authors
KeywordsCommunity-Acquired Methicillin-Resistant Staphylococcus Aureus (Ca-Mrsa)
Comparative Genomics
Diversity
Evolution
Infections
St8 Ca-Mrsa/J
Toxic Shock Syndrome Toxin-1 (Tsst-1)
Issue Date2012
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10156/index.htm
Citation
Journal Of Infection And Chemotherapy, 2012, v. 18 n. 2, p. 228-240 How to Cite?
AbstractCommunity-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCC mecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCC mecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8 Jα to γ. Of those, ST8 Jβ was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine leukocidin phage and arginine catabolic mobile element, unlike USA300. The unique features of ST8 CA-MRSA/J included a novel mosaic SaPI (designated SaPIj50) carrying the toxic shock syndrome toxin-1 gene with high expression; the evolution included salvage (through recombination) of hospital-acquired MRSA virulence. The data suggest that ST8 CA-MRSA/J has become a successful native clone in Japan, in association with not only SSTIs but also severe invasive infections (posing a threat), requiring attention. © 2012 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
Persistent Identifierhttp://hdl.handle.net/10722/157677
ISSN
2014 Impact Factor: 1.486
2014 SCImago Journal Rankings: 0.621
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIwao, Yen_US
dc.contributor.authorIshii, Ren_US
dc.contributor.authorTomita, Yen_US
dc.contributor.authorShibuya, Yen_US
dc.contributor.authorTakano, Ten_US
dc.contributor.authorHung, WCen_US
dc.contributor.authorHiguchi, Wen_US
dc.contributor.authorIsobe, Hen_US
dc.contributor.authorNishiyama, Aen_US
dc.contributor.authorYano, Men_US
dc.contributor.authorMatsumoto, Ten_US
dc.contributor.authorOgata, Ken_US
dc.contributor.authorOkubo, Ten_US
dc.contributor.authorKhokhlova, Oen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorYamamoto, Ten_US
dc.date.accessioned2012-08-08T08:52:10Z-
dc.date.available2012-08-08T08:52:10Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Infection And Chemotherapy, 2012, v. 18 n. 2, p. 228-240en_US
dc.identifier.issn1341-321Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/157677-
dc.description.abstractCommunity-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a major concern worldwide. In the United States, ST8 CA-MRSA with SCC mecIVa (USA300) has been predominant, affecting the entire United States. In this study, we investigated Japanese ST8 CA-MRSA with new SCC mecIVl (designated ST8 CA-MRSA/J), which has emerged in Japan since 2003. Regarding community spread and infections, ST8 CA-MRSA/J spread in 16.2-34.4% as a major genotype in the community in Japan, and was associated with skin and soft tissue infections (SSTIs), colitis, and invasive infections (sepsis, epidural abscesses, and necrotizing pneumonia), including influenza prodrome cases and athlete infections, similar to USA300. It spread to even public transport and Hong Kong through a Japanese family. Regarding genetic diversity, ST8 CA-MRSA/J included ST and spa variants and was classified into at least three pulsed-field gel electrophoresis types, ST8 Jα to γ. Of those, ST8 Jβ was associated with severe invasive infections. As for genomics, ST8 CA-MRSA/J showed high similarities to USA300, but with marked diversity in accessory genes; e.g., ST8 CA-MRSA/J possessed enhanced cytolytic peptide genes of CA-MRSA, but lacked the Panton-Valentine leukocidin phage and arginine catabolic mobile element, unlike USA300. The unique features of ST8 CA-MRSA/J included a novel mosaic SaPI (designated SaPIj50) carrying the toxic shock syndrome toxin-1 gene with high expression; the evolution included salvage (through recombination) of hospital-acquired MRSA virulence. The data suggest that ST8 CA-MRSA/J has become a successful native clone in Japan, in association with not only SSTIs but also severe invasive infections (posing a threat), requiring attention. © 2012 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.en_US
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10156/index.htmen_US
dc.relation.ispartofJournal of Infection and Chemotherapyen_US
dc.subjectCommunity-Acquired Methicillin-Resistant Staphylococcus Aureus (Ca-Mrsa)en_US
dc.subjectComparative Genomicsen_US
dc.subjectDiversityen_US
dc.subjectEvolutionen_US
dc.subjectInfectionsen_US
dc.subjectSt8 Ca-Mrsa/Jen_US
dc.subjectToxic Shock Syndrome Toxin-1 (Tsst-1)en_US
dc.titleThe emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomicsen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10156-012-0379-6en_US
dc.identifier.pmid22350401-
dc.identifier.scopuseid_2-s2.0-84863318559-
dc.identifier.hkuros209787-
dc.identifier.issue2-
dc.identifier.spage228en_US
dc.identifier.epage240en_US
dc.identifier.isiWOS:000303057800012-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridIwao, Y=16028482600en_US
dc.identifier.scopusauthoridIshii, R=23469691000en_US
dc.identifier.scopusauthoridTomita, Y=36777696800en_US
dc.identifier.scopusauthoridShibuya, Y=54985453600en_US
dc.identifier.scopusauthoridTakano, T=13007211800en_US
dc.identifier.scopusauthoridHung, WC=54989586100en_US
dc.identifier.scopusauthoridHiguchi, W=7102245163en_US
dc.identifier.scopusauthoridIsobe, H=8598658900en_US
dc.identifier.scopusauthoridNishiyama, A=36916636000en_US
dc.identifier.scopusauthoridYano, M=54984398500en_US
dc.identifier.scopusauthoridMatsumoto, T=7407962381en_US
dc.identifier.scopusauthoridOgata, K=7201445057en_US
dc.identifier.scopusauthoridOkubo, T=14023371800en_US
dc.identifier.scopusauthoridKhokhlova, O=54986821300en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridYamamoto, T=54984595700en_US
dc.identifier.citeulike10395880-

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