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Article: Continued evolution of highly pathogenic avian influenza A (H5N1): Updated nomenclature

TitleContinued evolution of highly pathogenic avian influenza A (H5N1): Updated nomenclature
Authors
Issue Date2012
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1
Citation
Influenza And Other Respiratory Viruses, 2012, v. 6 n. 1, p. 1-5 How to Cite?
AbstractPlease cite this paper as: WHO/OIE/FAO. (2012) Continued evolution of highly pathogenic avian influenza A(H5N1): Updated nomenclature. Influenza and Other Respiratory Viruses 6(1), 1-5. Background Continued evolution of highly pathogenic avian influenza A (H5N1) throughout many regions of the eastern hemisphere has led to the emergence of new phylogenetic groups. A total of 1637 new H5N1 hemagglutinin (HA) sequences have become available since the previous nomenclature recommendations described in 2009 by the WHO/OIE/FAO H5N1 Evolution Working Group. A comprehensive analysis including all the new data is needed to update HA clade nomenclature. Methods Phylogenetic trees were constructed from data sets of all available H5N1 HA sequences. New clades were designated on the basis of phylogeny and p-distance using the pre-established nomenclature system (Emerg Infec Dis 2008; 14:e1). Each circulating H5N1 clade was subjected to further phylogenetic analysis and nucleotide sequence divergence calculations. Results All recently circulating clades (clade 1 in the Mekong River Delta, 2.1.3 in Indonesia, 2.2 in India/Bangladesh, 2.2.1 in Egypt, 2.3.2, 2.3.4 and 7 in Asia) required assignment of divergent HA genes to new second-, third-, and/or fourth-order clades. At the same time, clades 0, 3, 4, 5, 6, 8, 9, and several second- and third-order groups from clade 2 have not been detected since 2008 or earlier. Conclusions New designations are recommended for 12 HA clades, named according to previously defined criteria. In addition, viruses from 13 clades have not been detected since 2008 or earlier. The periodic updating of this dynamic classification system allows continued use of a unified nomenclature in all H5N1 studies. © 2011 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/157662
ISSN
2015 Impact Factor: 2.378
2015 SCImago Journal Rankings: 1.570
ISI Accession Number ID
Funding AgencyGrant Number
Australian Government Department of Health and Ageing
Funding Information:

We thank Justin Bahl, Ian H. Brown, Giovanni Cattoli, Todd Davis, Ruben O. Donis, Ron A.M. Fouchier, Elizabeth Mumford, Pierre Rivailler, Gavin J.D. Smith, and Ian A. York for drafting the manuscript on behalf of the H5N1 Evolution Working Group. We also thank Justin Bahl, Todd Davis, Pierre Rivailler, and Gavin Smith for performing sequence and phylogenetic analyses. We acknowledge access to sequence information from the GISAID database. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. This publication contains the collective views of an international group of experts and does not necessarily represent the decisions or the stated policy of the Food and Agriculture Organization of the United Nations (FAO), the World Organisation for Animal Health (OIE), or the World Health Organization (WHO).

References

 

DC FieldValueLanguage
dc.contributor.authorSmith, GJDen_US
dc.contributor.authorDonis, ROen_US
dc.date.accessioned2012-08-08T08:52:02Z-
dc.date.available2012-08-08T08:52:02Z-
dc.date.issued2012en_US
dc.identifier.citationInfluenza And Other Respiratory Viruses, 2012, v. 6 n. 1, p. 1-5en_US
dc.identifier.issn1750-2640en_US
dc.identifier.urihttp://hdl.handle.net/10722/157662-
dc.description.abstractPlease cite this paper as: WHO/OIE/FAO. (2012) Continued evolution of highly pathogenic avian influenza A(H5N1): Updated nomenclature. Influenza and Other Respiratory Viruses 6(1), 1-5. Background Continued evolution of highly pathogenic avian influenza A (H5N1) throughout many regions of the eastern hemisphere has led to the emergence of new phylogenetic groups. A total of 1637 new H5N1 hemagglutinin (HA) sequences have become available since the previous nomenclature recommendations described in 2009 by the WHO/OIE/FAO H5N1 Evolution Working Group. A comprehensive analysis including all the new data is needed to update HA clade nomenclature. Methods Phylogenetic trees were constructed from data sets of all available H5N1 HA sequences. New clades were designated on the basis of phylogeny and p-distance using the pre-established nomenclature system (Emerg Infec Dis 2008; 14:e1). Each circulating H5N1 clade was subjected to further phylogenetic analysis and nucleotide sequence divergence calculations. Results All recently circulating clades (clade 1 in the Mekong River Delta, 2.1.3 in Indonesia, 2.2 in India/Bangladesh, 2.2.1 in Egypt, 2.3.2, 2.3.4 and 7 in Asia) required assignment of divergent HA genes to new second-, third-, and/or fourth-order clades. At the same time, clades 0, 3, 4, 5, 6, 8, 9, and several second- and third-order groups from clade 2 have not been detected since 2008 or earlier. Conclusions New designations are recommended for 12 HA clades, named according to previously defined criteria. In addition, viruses from 13 clades have not been detected since 2008 or earlier. The periodic updating of this dynamic classification system allows continued use of a unified nomenclature in all H5N1 studies. © 2011 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/subs.asp?ref=1750-2640&site=1en_US
dc.relation.ispartofInfluenza and other Respiratory Virusesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAsiaen_US
dc.subject.meshBirdsen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - Geneticsen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Classification - Geneticsen_US
dc.subject.meshInfluenza In Birds - Virologyen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshRna, Viral - Geneticsen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshTerminology As Topicen_US
dc.titleContinued evolution of highly pathogenic avian influenza A (H5N1): Updated nomenclatureen_US
dc.typeArticleen_US
dc.identifier.emailSmith, GJD:gjsmith@hkucc.hku.hken_US
dc.identifier.authoritySmith, GJD=rp00444en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1750-2659.2011.00298.xen_US
dc.identifier.pmid22035148-
dc.identifier.scopuseid_2-s2.0-83555173308en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83555173308&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage5en_US
dc.identifier.isiWOS:000298015000001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSmith, GJD=8344015800en_US
dc.identifier.scopusauthoridDonis, RO=35261680000en_US

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