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Article: MicroRNAs and cancer therapeutics

TitleMicroRNAs and cancer therapeutics
Authors
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2011, v. 28 n. 12, p. 3043-3049 How to Cite?
AbstractMicroRNAs (miRNAs) are small physiological non-coding RNAs that regulate gene expression through an RNA interference (RNAi) mechanism. The expression of miRNAs is tightly controlled both spatially and temporally. Aberrant miRNA expression has been correlated with various cancers. Recent findings suggest that some miRNAs can function as tumor suppressors or oncogenes. In model experiments, the cancer phenotype of some cells can be reverted to normal when the cells are treated with miRNA mimics or inhibitors. Here, we discuss in brief the potential utility of miRNA-based cancer therapy as well as the current limitations thwarting their useful clinical application. © 2011 Springer Science + Business Media, LLC (outside the USA).
Persistent Identifierhttp://hdl.handle.net/10722/157660
ISSN
2015 Impact Factor: 3.26
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, MLen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-08-08T08:52:01Z-
dc.date.available2012-08-08T08:52:01Z-
dc.date.issued2011en_US
dc.identifier.citationPharmaceutical Research, 2011, v. 28 n. 12, p. 3043-3049en_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttp://hdl.handle.net/10722/157660-
dc.description.abstractMicroRNAs (miRNAs) are small physiological non-coding RNAs that regulate gene expression through an RNA interference (RNAi) mechanism. The expression of miRNAs is tightly controlled both spatially and temporally. Aberrant miRNA expression has been correlated with various cancers. Recent findings suggest that some miRNAs can function as tumor suppressors or oncogenes. In model experiments, the cancer phenotype of some cells can be reverted to normal when the cells are treated with miRNA mimics or inhibitors. Here, we discuss in brief the potential utility of miRNA-based cancer therapy as well as the current limitations thwarting their useful clinical application. © 2011 Springer Science + Business Media, LLC (outside the USA).en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741en_US
dc.relation.ispartofPharmaceutical Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGene Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMicrornas - Administration & Dosage - Genetics - Therapeutic Useen_US
dc.subject.meshNanoparticles - Chemistryen_US
dc.subject.meshNeoplasms - Genetics - Therapyen_US
dc.subject.meshOncogenes - Geneticsen_US
dc.subject.meshRna Interferenceen_US
dc.titleMicroRNAs and cancer therapeuticsen_US
dc.typeArticleen_US
dc.identifier.emailYeung, ML:pmlyeung@hku.hken_US
dc.identifier.authorityYeung, ML=rp01402en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11095-011-0526-2en_US
dc.identifier.pmid21773853-
dc.identifier.scopuseid_2-s2.0-83455206025en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83455206025&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue12en_US
dc.identifier.spage3043en_US
dc.identifier.epage3049en_US
dc.identifier.isiWOS:000297710200007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYeung, ML=8350940900en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US
dc.identifier.citeulike9589792-

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