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Article: Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong

TitleChanges in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology and Infectious Disease, 2011, v. 71 n. 4, p. 327-334 How to Cite?
AbstractThis study assessed the changes in serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates in children before and after introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. Nasopharyngeal specimens were collected from 1978 and 2211 children (ages, 2 to 6 years) attending day care centers or kindergartens in period 1 (1999-2000) and period 2 (2009-2010), respectively. Carriage of PCV7 serotypes decreased from 12.8% to 8.6% (P < 0.01). The relative contribution of PCV7 serotypes 14 and 18C had decreased, whereas that for non-PCV7 serotypes 19A, 6A, 6C, 23A, and 15B had increased. In period 2, PCV7 penetration rate (at least 1 dose) for children aged 2, 3, 4, and 5 years was 43%, 35.7%, 26.7%, and 20.4%, respectively. In multivariate analysis, PCV7 use was the only independent variable associated with fewer PCV7 serotype carriages (odds ratio 0.5; P = 0.001). In period 2, high rates of dual penicillin/erythromycin nonsusceptibility were found in serotypes 6B (77.3%), 14 (100%), 19F (100%), 23F (78%), 19A (75%), 6A (87.8%), 6C (59.3%), and 23A (78.9%).
Persistent Identifierhttp://hdl.handle.net/10722/157658
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142
ISI Accession Number ID
Funding AgencyGrant Number
Health and Food Bureau of the Hong Kong SAR Government
Funding Information:

This study is supported by research grants from the Research Fund for the Control of Infectious Diseases (RFCID) of the Health and Food Bureau of the Hong Kong SAR Government.

References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorChan, MYen_HK
dc.contributor.authorAng, Ien_HK
dc.contributor.authorChow, KHen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2012-08-08T08:52:00Z-
dc.date.available2012-08-08T08:52:00Z-
dc.date.issued2011en_HK
dc.identifier.citationDiagnostic Microbiology and Infectious Disease, 2011, v. 71 n. 4, p. 327-334en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157658-
dc.description.abstractThis study assessed the changes in serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates in children before and after introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in Hong Kong. Nasopharyngeal specimens were collected from 1978 and 2211 children (ages, 2 to 6 years) attending day care centers or kindergartens in period 1 (1999-2000) and period 2 (2009-2010), respectively. Carriage of PCV7 serotypes decreased from 12.8% to 8.6% (P < 0.01). The relative contribution of PCV7 serotypes 14 and 18C had decreased, whereas that for non-PCV7 serotypes 19A, 6A, 6C, 23A, and 15B had increased. In period 2, PCV7 penetration rate (at least 1 dose) for children aged 2, 3, 4, and 5 years was 43%, 35.7%, 26.7%, and 20.4%, respectively. In multivariate analysis, PCV7 use was the only independent variable associated with fewer PCV7 serotype carriages (odds ratio 0.5; P = 0.001). In period 2, high rates of dual penicillin/erythromycin nonsusceptibility were found in serotypes 6B (77.3%), 14 (100%), 19F (100%), 23F (78%), 19A (75%), 6A (87.8%), 6C (59.3%), and 23A (78.9%).en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Diagnostic Microbiology and Infectious Disease. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Diagnostic Microbiology and Infectious Disease, 2011, v. 71 n. 4, p. 327-334. DOI: 10.1016/j.diagmicrobio.2011.09.006-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarrier State - epidemiology - microbiology-
dc.subject.meshNasopharynx - microbiology-
dc.subject.meshPneumococcal Infections - epidemiology - microbiology-
dc.subject.meshPneumococcal Vaccines - administration and dosage - immunology-
dc.subject.meshStreptococcus pneumoniae - classification - drug effects - isolation and purification-
dc.titleChanges in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumoniae before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailChiu, SS: ssschiu@hku.hken_HK
dc.identifier.emailChan, MY: plho@hkucc.hku.hken_HK
dc.identifier.emailAng, I: ireneang@hku.hken_HK
dc.identifier.emailChow, KH: khchowb@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityChow, KH=rp00370en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepostprinten_US
dc.identifier.doi10.1016/j.diagmicrobio.2011.09.006en_HK
dc.identifier.pmid22000087-
dc.identifier.scopuseid_2-s2.0-82555169636en_HK
dc.identifier.hkuros200702-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82555169636&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue4en_HK
dc.identifier.spage327en_HK
dc.identifier.epage334en_HK
dc.identifier.isiWOS:000297529800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridChow, KH=7202180736en_HK
dc.identifier.scopusauthoridAng, I=55214129400en_HK
dc.identifier.scopusauthoridChan, MY=37109508300en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.citeulike9927265-

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