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- Publisher Website: 10.2217/fvl.11.109
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Article: Roles of miRNAs in virus-mediated cellular transformation: Lessons from human T-cell leukemia virus type 1
Title | Roles of miRNAs in virus-mediated cellular transformation: Lessons from human T-cell leukemia virus type 1 |
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Authors | |
Keywords | Antagomir Atl Cancer Htlv-1 Mirna Rnai Tax |
Issue Date | 2011 |
Publisher | Future Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl |
Citation | Future Virology, 2011, v. 6 n. 11, p. 1351-1360 How to Cite? |
Abstract | miRNAs are small noncoding RNAs of ∼18-25 nucleotides that contribute to the regulation of a diverse variety of biological pathways. Perturbed miRNA expression is seen in many diseases, including cancers. Here, we first discuss the oncogenic and tumor suppressor roles of miRNA, including the roles played by miRNAs in the replication of some oncogenic viruses. Next, using human T-cell leukemia virus type 1 as an example, we discuss the contributions of virus-induced miRNAs in human T-cell leukemia virus type 1-transformation of human cells. Finally, we briefly survey the therapeutic potential of miRNA mimics or anti-miRNAs, antagomirs, to reverse cancer phenotypes. © 2011 Future Medicine Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/157656 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.366 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Yeung, ML | en_US |
dc.contributor.author | Jeang, KT | en_US |
dc.date.accessioned | 2012-08-08T08:51:59Z | - |
dc.date.available | 2012-08-08T08:51:59Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Future Virology, 2011, v. 6 n. 11, p. 1351-1360 | en_US |
dc.identifier.issn | 1746-0794 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/157656 | - |
dc.description.abstract | miRNAs are small noncoding RNAs of ∼18-25 nucleotides that contribute to the regulation of a diverse variety of biological pathways. Perturbed miRNA expression is seen in many diseases, including cancers. Here, we first discuss the oncogenic and tumor suppressor roles of miRNA, including the roles played by miRNAs in the replication of some oncogenic viruses. Next, using human T-cell leukemia virus type 1 as an example, we discuss the contributions of virus-induced miRNAs in human T-cell leukemia virus type 1-transformation of human cells. Finally, we briefly survey the therapeutic potential of miRNA mimics or anti-miRNAs, antagomirs, to reverse cancer phenotypes. © 2011 Future Medicine Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | Future Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl | en_US |
dc.relation.ispartof | Future Virology | en_US |
dc.subject | Antagomir | en_US |
dc.subject | Atl | en_US |
dc.subject | Cancer | en_US |
dc.subject | Htlv-1 | en_US |
dc.subject | Mirna | en_US |
dc.subject | Rnai | en_US |
dc.subject | Tax | en_US |
dc.title | Roles of miRNAs in virus-mediated cellular transformation: Lessons from human T-cell leukemia virus type 1 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yeung, ML:pmlyeung@hku.hk | en_US |
dc.identifier.authority | Yeung, ML=rp01402 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.2217/fvl.11.109 | en_US |
dc.identifier.scopus | eid_2-s2.0-80755159110 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80755159110&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 1351 | en_US |
dc.identifier.epage | 1360 | en_US |
dc.identifier.isi | WOS:000297219000013 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Yeung, ML=8350940900 | en_US |
dc.identifier.scopusauthorid | Jeang, KT=7004824803 | en_US |
dc.identifier.issnl | 1746-0794 | - |