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Article: Roles of miRNAs in virus-mediated cellular transformation: Lessons from human T-cell leukemia virus type 1

TitleRoles of miRNAs in virus-mediated cellular transformation: Lessons from human T-cell leukemia virus type 1
Authors
KeywordsAntagomir
Atl
Cancer
Htlv-1
Mirna
Rnai
Tax
Issue Date2011
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvl
Citation
Future Virology, 2011, v. 6 n. 11, p. 1351-1360 How to Cite?
AbstractmiRNAs are small noncoding RNAs of ∼18-25 nucleotides that contribute to the regulation of a diverse variety of biological pathways. Perturbed miRNA expression is seen in many diseases, including cancers. Here, we first discuss the oncogenic and tumor suppressor roles of miRNA, including the roles played by miRNAs in the replication of some oncogenic viruses. Next, using human T-cell leukemia virus type 1 as an example, we discuss the contributions of virus-induced miRNAs in human T-cell leukemia virus type 1-transformation of human cells. Finally, we briefly survey the therapeutic potential of miRNA mimics or anti-miRNAs, antagomirs, to reverse cancer phenotypes. © 2011 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/157656
ISSN
2015 Impact Factor: 0.886
2015 SCImago Journal Rankings: 0.529
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, MLen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-08-08T08:51:59Z-
dc.date.available2012-08-08T08:51:59Z-
dc.date.issued2011en_US
dc.identifier.citationFuture Virology, 2011, v. 6 n. 11, p. 1351-1360en_US
dc.identifier.issn1746-0794en_US
dc.identifier.urihttp://hdl.handle.net/10722/157656-
dc.description.abstractmiRNAs are small noncoding RNAs of ∼18-25 nucleotides that contribute to the regulation of a diverse variety of biological pathways. Perturbed miRNA expression is seen in many diseases, including cancers. Here, we first discuss the oncogenic and tumor suppressor roles of miRNA, including the roles played by miRNAs in the replication of some oncogenic viruses. Next, using human T-cell leukemia virus type 1 as an example, we discuss the contributions of virus-induced miRNAs in human T-cell leukemia virus type 1-transformation of human cells. Finally, we briefly survey the therapeutic potential of miRNA mimics or anti-miRNAs, antagomirs, to reverse cancer phenotypes. © 2011 Future Medicine Ltd.en_US
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fvlen_US
dc.relation.ispartofFuture Virologyen_US
dc.subjectAntagomiren_US
dc.subjectAtlen_US
dc.subjectCanceren_US
dc.subjectHtlv-1en_US
dc.subjectMirnaen_US
dc.subjectRnaien_US
dc.subjectTaxen_US
dc.titleRoles of miRNAs in virus-mediated cellular transformation: Lessons from human T-cell leukemia virus type 1en_US
dc.typeArticleen_US
dc.identifier.emailYeung, ML:pmlyeung@hku.hken_US
dc.identifier.authorityYeung, ML=rp01402en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2217/fvl.11.109en_US
dc.identifier.scopuseid_2-s2.0-80755159110en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80755159110&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue11en_US
dc.identifier.spage1351en_US
dc.identifier.epage1360en_US
dc.identifier.isiWOS:000297219000013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYeung, ML=8350940900en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

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