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Article: High incidence of severe influenza among individuals over 50 years of age

TitleHigh incidence of severe influenza among individuals over 50 years of age
Authors
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/
Citation
Clinical And Vaccine Immunology, 2011, v. 18 n. 11, p. 1918-1924 How to Cite?
AbstractAge-specific epidemiological data on asymptomatic, symptomatic, and severe infections are essential for public health policies on combating influenza. In this study, we incorporated data on microbiologically confirmed infections and seroprevalence to comprehensively describe the epidemiology of pandemic H1N1 2009 influenza. Seroprevalence was determined from 1,795 random serum samples collected in our hospital in January 2007 (before the first wave of the pandemic) and March 2010 (after the second wave). Data on microbiologically confirmed infection and severe cases were obtained from the Centre for Health Protection in Hong Kong. Severe cases were most common in the 51- to 60-year-old age group. The microbiologically confirmed incidence rate was highest for children aged ≤10 years and dropped sharply for the adult population (ρ = -1.0; P < 0.01), but the incidence rate for severe disease was highest for the 51- to 60-year-old age group. For the 51- to 60-year-old age group, the seroprevalence was similar to that for the younger age groups, but the proportion of severe cases relative to seroprevalence was significantly higher than that for 11- to 50-year-old age groups. As judged from the percentage of specimens positive for other respiratory viruses compared with that for pandemic H1N1 virus, the impact of symptomatic disease due to pandemic H1N1 virus was higher than that for other respiratory viruses in people aged ≤50 years. In conclusion, the 51- to 60-year-old age group, which had the highest overall incidence and the highest rate of severe disease but is currently not considered by the World Health Organization to be an at-risk group, should be prioritized for influenza vaccination in areas where universal influenza vaccination is not practiced. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157654
ISSN
2015 Impact Factor: 2.277
2015 SCImago Journal Rankings: 1.329
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Science and Technology Major Project of China2009ZX10004-306
Ted Sun Foundation
Clinical Infectious Diseases Research Endowment Fund
Food and Health Bureau
Research Grants Council of the Hong Kong Special Administrative Region, China
Funding Information:

This work was supported by the National Science and Technology Major Project of China (grant 2009ZX10004-306), the Ted Sun Foundation, the Clinical Infectious Diseases Research Endowment Fund from Teresa Wong On Yik, the Research Fund for the Control of Infectious Diseases of the Food and Health Bureau, and the Research Grants Council of the Hong Kong Special Administrative Region, China.

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, AJXen_HK
dc.contributor.authorTo, KKWen_HK
dc.contributor.authorTse, Hen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorGuo, KYen_HK
dc.contributor.authorLi, Cen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorChan, JFWen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2012-08-08T08:51:59Z-
dc.date.available2012-08-08T08:51:59Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical And Vaccine Immunology, 2011, v. 18 n. 11, p. 1918-1924en_HK
dc.identifier.issn1556-6811en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157654-
dc.description.abstractAge-specific epidemiological data on asymptomatic, symptomatic, and severe infections are essential for public health policies on combating influenza. In this study, we incorporated data on microbiologically confirmed infections and seroprevalence to comprehensively describe the epidemiology of pandemic H1N1 2009 influenza. Seroprevalence was determined from 1,795 random serum samples collected in our hospital in January 2007 (before the first wave of the pandemic) and March 2010 (after the second wave). Data on microbiologically confirmed infection and severe cases were obtained from the Centre for Health Protection in Hong Kong. Severe cases were most common in the 51- to 60-year-old age group. The microbiologically confirmed incidence rate was highest for children aged ≤10 years and dropped sharply for the adult population (ρ = -1.0; P < 0.01), but the incidence rate for severe disease was highest for the 51- to 60-year-old age group. For the 51- to 60-year-old age group, the seroprevalence was similar to that for the younger age groups, but the proportion of severe cases relative to seroprevalence was significantly higher than that for 11- to 50-year-old age groups. As judged from the percentage of specimens positive for other respiratory viruses compared with that for pandemic H1N1 virus, the impact of symptomatic disease due to pandemic H1N1 virus was higher than that for other respiratory viruses in people aged ≤50 years. In conclusion, the 51- to 60-year-old age group, which had the highest overall incidence and the highest rate of severe disease but is currently not considered by the World Health Organization to be an at-risk group, should be prioritized for influenza vaccination in areas where universal influenza vaccination is not practiced. Copyright © 2011, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://cdli.asm.org/en_HK
dc.relation.ispartofClinical and Vaccine Immunologyen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshInfluenza A Virus, H1n1 Subtype - Isolation & Purification - Pathogenicityen_US
dc.subject.meshInfluenza, Human - Epidemiology - Pathology - Virologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshYoung Adulten_US
dc.titleHigh incidence of severe influenza among individuals over 50 years of ageen_HK
dc.typeArticleen_HK
dc.identifier.emailZhang, AJX: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hken_HK
dc.identifier.emailTse, H: htse@hkucc.hku.hken_HK
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailChan, JFW: jfwchan@hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityZhang, AJX=rp00413en_HK
dc.identifier.authorityTo, KKW=rp01384en_HK
dc.identifier.authorityTse, H=rp00519en_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityChan, JFW=rp01736en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1128/CVI.05357-11en_HK
dc.identifier.pmid21900532-
dc.identifier.pmcidPMC3209033-
dc.identifier.scopuseid_2-s2.0-80455128645en_HK
dc.identifier.hkuros208520-
dc.identifier.hkuros203198-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80455128645&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1918en_HK
dc.identifier.epage1924en_HK
dc.identifier.isiWOS:000296613800019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, AJX=12752135600en_HK
dc.identifier.scopusauthoridTo, KKW=14323807300en_HK
dc.identifier.scopusauthoridTse, H=7006070596en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridGuo, KY=25623179500en_HK
dc.identifier.scopusauthoridLi, C=54418721000en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridChan, JFW=24278817900en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridTam, S=36947522200en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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