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Article: Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humans

TitleNovel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humans
Authors
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2011, v. 85 n. 20, p. 10432-10439 How to Cite?
AbstractPigs are considered to be intermediate hosts and "mixing vessels," facilitating the genesis of pandemic influenza viruses, as demonstrated by the emergence of the 2009 H1N1 pandemic (pdm/09) virus. The prevalence and repeated introduction of the pdm/09 virus into pigs raises the possibility of generating novel swine influenza viruses with the potential to infect humans. To address this, an active influenza surveillance program was conducted with slaughtered pigs in abattoirs in southern China. Over 50% of the pigs tested were found to be seropositive for one or more H1 influenza viruses, most commonly pdm/09-like viruses. Out of 36 virus isolates detected, one group of novel reassortants had Eurasian avian-like swine H1N1 surface genes and pdm/09 internal genes. Animal experiments showed that this virus transmitted effectively from pig to pig and from pig to ferret, and it could also replicate in ex vivo human lung tissue. Immunization against the 2009 pandemic virus gave only partial protection to ferrets. The continuing prevalence of the pdm/09 virus in pigs could lead to the genesis of novel swine reassortant viruses with the potential to infect humans. © 2011, American Society for Microbiology.
Persistent Identifierhttp://hdl.handle.net/10722/157651
ISSN
2014 Impact Factor: 4.439
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health (National Institute of Allergy and Infectious Diseases)HSN266200700005C
Li Ka Shing Foundation
University Grants Committee of the Hong Kong SARAoE/M-12/06
Funding Information:

This work was supported by the National Institutes of Health (National Institute of Allergy and Infectious Diseases contract HSN266200700005C), the Li Ka Shing Foundation, and the Area of Excellence Scheme of the University Grants Committee of the Hong Kong SAR (grant AoE/M-12/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorZhou, Ben_HK
dc.contributor.authorFan, Xen_HK
dc.contributor.authorLam, TTYen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorChen, Aen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorWebby, Ren_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorSmith, DKen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2012-08-08T08:51:57Z-
dc.date.available2012-08-08T08:51:57Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Virology, 2011, v. 85 n. 20, p. 10432-10439en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/157651-
dc.description.abstractPigs are considered to be intermediate hosts and "mixing vessels," facilitating the genesis of pandemic influenza viruses, as demonstrated by the emergence of the 2009 H1N1 pandemic (pdm/09) virus. The prevalence and repeated introduction of the pdm/09 virus into pigs raises the possibility of generating novel swine influenza viruses with the potential to infect humans. To address this, an active influenza surveillance program was conducted with slaughtered pigs in abattoirs in southern China. Over 50% of the pigs tested were found to be seropositive for one or more H1 influenza viruses, most commonly pdm/09-like viruses. Out of 36 virus isolates detected, one group of novel reassortants had Eurasian avian-like swine H1N1 surface genes and pdm/09 internal genes. Animal experiments showed that this virus transmitted effectively from pig to pig and from pig to ferret, and it could also replicate in ex vivo human lung tissue. Immunization against the 2009 pandemic virus gave only partial protection to ferrets. The continuing prevalence of the pdm/09 virus in pigs could lead to the genesis of novel swine reassortant viruses with the potential to infect humans. © 2011, American Society for Microbiology.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, 2011, v. 85 n. 20, p. 10432-10439]-
dc.subject.meshInfluenza A virus - classification - genetics - isolation and purification - pathogenicityen_US
dc.subject.meshOrthomyxoviridae Infections - transmission - virologyen_US
dc.subject.meshRNA, Viral - geneticsen_US
dc.subject.meshReassortant Viruses - classification - genetics - isolation and purification - pathogenicityen_US
dc.subject.meshSwine - virologyen_US
dc.titleNovel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humansen_HK
dc.typeArticleen_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailLam, TTY: ttylam@hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authorityLam, TTY=rp01733en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1128/JVI.05352-11en_HK
dc.identifier.pmid21849442en_HK
dc.identifier.pmcidPMC3187487-
dc.identifier.scopuseid_2-s2.0-80054981148en_HK
dc.identifier.hkuros203150-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054981148&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue20en_HK
dc.identifier.spage10432en_HK
dc.identifier.epage10439en_HK
dc.identifier.isiWOS:000296254100001-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridZhou, B=7401906727en_HK
dc.identifier.scopusauthoridFan, X=36023320000en_HK
dc.identifier.scopusauthoridLam, TTY=36775821700en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridChen, A=55447340500en_HK
dc.identifier.scopusauthoridChen, X=8710357400en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridWebby, R=35448064800en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridSmith, DK=7410351143en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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