Article: Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humans
| Title | Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humans | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Zhu, H Zhou, B Fan, X Lam, TTY Wang, J Chen, A Chen, X Chen, H Webster, RG Webby, R Peiris, JSM Smith, DK Guan, Y | ||||||||
| Issue Date | 2011 | ||||||||
| Publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | ||||||||
| Citation | Journal Of Virology, 2011, v. 85 n. 20, p. 10432-10439 [How to Cite?] DOI: http://dx.doi.org/10.1128/JVI.05352-11 | ||||||||
| Abstract | Pigs are considered to be intermediate hosts and "mixing vessels," facilitating the genesis of pandemic influenza viruses, as demonstrated by the emergence of the 2009 H1N1 pandemic (pdm/09) virus. The prevalence and repeated introduction of the pdm/09 virus into pigs raises the possibility of generating novel swine influenza viruses with the potential to infect humans. To address this, an active influenza surveillance program was conducted with slaughtered pigs in abattoirs in southern China. Over 50% of the pigs tested were found to be seropositive for one or more H1 influenza viruses, most commonly pdm/09-like viruses. Out of 36 virus isolates detected, one group of novel reassortants had Eurasian avian-like swine H1N1 surface genes and pdm/09 internal genes. Animal experiments showed that this virus transmitted effectively from pig to pig and from pig to ferret, and it could also replicate in ex vivo human lung tissue. Immunization against the 2009 pandemic virus gave only partial protection to ferrets. The continuing prevalence of the pdm/09 virus in pigs could lead to the genesis of novel swine reassortant viruses with the potential to infect humans. © 2011, American Society for Microbiology. | ||||||||
| ISSN | 0022-538X 2011 Impact Factor: 5.402 2011 SCImago Journal Rankings: 0.745 | ||||||||
| DOI | http://dx.doi.org/10.1128/JVI.05352-11 | ||||||||
| ISI Accession Number ID | WOS:000296254100001
Funding Information: This work was supported by the National Institutes of Health (National Institute of Allergy and Infectious Diseases contract HSN266200700005C), the Li Ka Shing Foundation, and the Area of Excellence Scheme of the University Grants Committee of the Hong Kong SAR (grant AoE/M-12/06). | ||||||||
| PubMed Central ID | PMC3187487 | ||||||||
| References | References in Scopus | ||||||||
| Grants | Control of Pandemic and Inter-pandemic Influenza |
| dc.contributor.author | Zhu, H | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zhou, B | ||||||||
| dc.contributor.author | Fan, X | ||||||||
| dc.contributor.author | Lam, TTY | ||||||||
| dc.contributor.author | Wang, J | ||||||||
| dc.contributor.author | Chen, A | ||||||||
| dc.contributor.author | Chen, X | ||||||||
| dc.contributor.author | Chen, H | ||||||||
| dc.contributor.author | Webster, RG | ||||||||
| dc.contributor.author | Webby, R | ||||||||
| dc.contributor.author | Peiris, JSM | ||||||||
| dc.contributor.author | Smith, DK | ||||||||
| dc.contributor.author | Guan, Y | ||||||||
| dc.date.accessioned | 2012-08-08T08:51:57Z | ||||||||
| dc.date.available | 2012-08-08T08:51:57Z | ||||||||
| dc.date.issued | 2011 | ||||||||
| dc.description.abstract | Pigs are considered to be intermediate hosts and "mixing vessels," facilitating the genesis of pandemic influenza viruses, as demonstrated by the emergence of the 2009 H1N1 pandemic (pdm/09) virus. The prevalence and repeated introduction of the pdm/09 virus into pigs raises the possibility of generating novel swine influenza viruses with the potential to infect humans. To address this, an active influenza surveillance program was conducted with slaughtered pigs in abattoirs in southern China. Over 50% of the pigs tested were found to be seropositive for one or more H1 influenza viruses, most commonly pdm/09-like viruses. Out of 36 virus isolates detected, one group of novel reassortants had Eurasian avian-like swine H1N1 surface genes and pdm/09 internal genes. Animal experiments showed that this virus transmitted effectively from pig to pig and from pig to ferret, and it could also replicate in ex vivo human lung tissue. Immunization against the 2009 pandemic virus gave only partial protection to ferrets. The continuing prevalence of the pdm/09 virus in pigs could lead to the genesis of novel swine reassortant viruses with the potential to infect humans. © 2011, American Society for Microbiology. | ||||||||
| dc.description.grant | Control of Pandemic and Inter-pandemic Influenza | ||||||||
| dc.description.grantcode | 97655 | ||||||||
| dc.description.nature | link_to_OA_fulltext | ||||||||
| dc.identifier.citation | Journal Of Virology, 2011, v. 85 n. 20, p. 10432-10439 [How to Cite?] DOI: http://dx.doi.org/10.1128/JVI.05352-11 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1128/JVI.05352-11 | ||||||||
| dc.identifier.epage | 10439 | ||||||||
| dc.identifier.hkuros | 203150 | ||||||||
| dc.identifier.isi | WOS:000296254100001
Funding Information: This work was supported by the National Institutes of Health (National Institute of Allergy and Infectious Diseases contract HSN266200700005C), the Li Ka Shing Foundation, and the Area of Excellence Scheme of the University Grants Committee of the Hong Kong SAR (grant AoE/M-12/06). | ||||||||
| dc.identifier.issn | 0022-538X 2011 Impact Factor: 5.402 2011 SCImago Journal Rankings: 0.745 | ||||||||
| dc.identifier.issue | 20 | ||||||||
| dc.identifier.pmcid | PMC3187487 | ||||||||
| dc.identifier.pmid | 21849442 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-80054981148 | ||||||||
| dc.identifier.spage | 10432 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/157651 | ||||||||
| dc.identifier.volume | 85 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | ||||||||
| dc.publisher.place | United States | ||||||||
| dc.relation.ispartof | Journal of Virology | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.rights | Journal of Virology. Copyright © American Society for Microbiology. | ||||||||
| dc.rights | Copyright © American Society for Microbiology, [Journal of Virology, 2011, v. 85 n. 20, p. 10432-10439] | ||||||||
| dc.subject.mesh | Influenza A virus - classification - genetics - isolation and purification - pathogenicity | ||||||||
| dc.subject.mesh | Orthomyxoviridae Infections - transmission - virology | ||||||||
| dc.subject.mesh | RNA, Viral - genetics | ||||||||
| dc.subject.mesh | Reassortant Viruses - classification - genetics - isolation and purification - pathogenicity | ||||||||
| dc.subject.mesh | Swine - virology | ||||||||
| dc.title | Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: Infectious potential for humans | ||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- The University of Hong Kong
- Shantou University, Medical College (SUMC)
- Guangxi Medical University
- Wuxi Sangosho Pet Park Co. Ltd.
- St. Jude Children's Research Hospital