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Article: Prevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development.

TitlePrevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development.
Authors
Issue Date2011
PublisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journal
Citation
British Journal Of Biomedical Science, 2011, v. 68 n. 3, p. 143-146 How to Cite?
AbstractChronic hepatitis B virus (HBV) infection is a global problem and over 75% of cases are reported in the Asia Pacific region. Infection can lead to progressive liver disease, cirrhosis and hepatocellular carcinoma (HCC). Previous studies suggest the prevalence of HBV carriers in Macau to be approximately 10% of the population. This study aims to investigate the prevalence of HBV genotypes among HBV-positive teenagers in Macao and the prevalence of base core promoter (BCP) and precore (PreC) mutations in the viral genome. In addition, through monitoring aminotransferase and alpha-fetoprotein, it aims to investigate relationships among HBV genotypes, BCP/PreC mutations and HCC development. This study recruited 1991 teenagers in Macau in 2008, and the PreS1/S2, BCP and PreC region of the HBV genome from 34 HBsAg-positive subjects were amplified and sequenced to determine HBV genotype and presence of HCC-associated mutations. Results suggested that the average rate of HBV infection among secondary school teenagers in Macao is low, and HBV genotype B and C viruses were found to predominate in Macao. The BCP/PreC mutations A1762T, G1764A, G1896A and C1766T were identified in 2.9-11.7% of subjects. However, no significant relationship was observed between HBV genotype, BCP/PreC mutations and HCC development.
Persistent Identifierhttp://hdl.handle.net/10722/157649
ISSN
2015 Impact Factor: 1.245
2015 SCImago Journal Rankings: 0.352
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChui, SHen_US
dc.contributor.authorChen, JHen_US
dc.contributor.authorSzeto, YTen_US
dc.contributor.authorYam, WCen_US
dc.date.accessioned2012-08-08T08:51:56Z-
dc.date.available2012-08-08T08:51:56Z-
dc.date.issued2011en_US
dc.identifier.citationBritish Journal Of Biomedical Science, 2011, v. 68 n. 3, p. 143-146en_US
dc.identifier.issn0967-4845en_US
dc.identifier.urihttp://hdl.handle.net/10722/157649-
dc.description.abstractChronic hepatitis B virus (HBV) infection is a global problem and over 75% of cases are reported in the Asia Pacific region. Infection can lead to progressive liver disease, cirrhosis and hepatocellular carcinoma (HCC). Previous studies suggest the prevalence of HBV carriers in Macau to be approximately 10% of the population. This study aims to investigate the prevalence of HBV genotypes among HBV-positive teenagers in Macao and the prevalence of base core promoter (BCP) and precore (PreC) mutations in the viral genome. In addition, through monitoring aminotransferase and alpha-fetoprotein, it aims to investigate relationships among HBV genotypes, BCP/PreC mutations and HCC development. This study recruited 1991 teenagers in Macau in 2008, and the PreS1/S2, BCP and PreC region of the HBV genome from 34 HBsAg-positive subjects were amplified and sequenced to determine HBV genotype and presence of HCC-associated mutations. Results suggested that the average rate of HBV infection among secondary school teenagers in Macao is low, and HBV genotype B and C viruses were found to predominate in Macao. The BCP/PreC mutations A1762T, G1764A, G1896A and C1766T were identified in 2.9-11.7% of subjects. However, no significant relationship was observed between HBV genotype, BCP/PreC mutations and HCC development.en_US
dc.languageengen_US
dc.publisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journalen_US
dc.relation.ispartofBritish journal of biomedical scienceen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshCarcinoma, Hepatocellular - Blood - Virologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B - Blood - Epidemiology - Virologyen_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Blood - Virologyen_US
dc.subject.meshMacau - Epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMutationen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshViral Core Proteins - Geneticsen_US
dc.subject.meshYoung Adulten_US
dc.subject.meshAlpha-Fetoproteins - Metabolismen_US
dc.titlePrevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development.en_US
dc.typeArticleen_US
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_US
dc.identifier.authorityYam, WC=rp00313en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid21950207-
dc.identifier.scopuseid_2-s2.0-80054073373en_US
dc.identifier.volume68en_US
dc.identifier.issue3en_US
dc.identifier.spage143en_US
dc.identifier.epage146en_US
dc.identifier.isiWOS:000295022400008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChui, SH=13204613800en_US
dc.identifier.scopusauthoridChen, JH=53363275200en_US
dc.identifier.scopusauthoridSzeto, YT=6603749114en_US
dc.identifier.scopusauthoridYam, WC=7004281720en_US

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