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Article: Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong
Title | Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong | ||||
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Authors | |||||
Issue Date | 2011 | ||||
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||
Citation | PLoS One, 2011, v. 6 n. 9, article no. e25286 How to Cite? | ||||
Abstract | The men-having-sex-with-men (MSM) population has become one of the major risk groups for HIV-1 infection in the Asia Pacific countries. Hong Kong is located in the centre of Asia and the transmission history of HIV-1 subtype B transmission among MSM remained unclear. The aim of this study was to investigate the transmission dynamics of HIV-1 subtype B virus in the Hong Kong MSM population. Samples of 125 HIV-1 subtype B infected MSM patients were recruited in this study. Through this study, the subtype B epidemic in the Hong Kong MSM population was identified spreading mainly among local Chinese who caught infection locally. On the other hand, HIV-1 subtype B infected Caucasian MSM caught infection mainly outside Hong Kong. The Bayesian phylogenetic analysis also indicated that 3 separate subtype B epidemics with divergence dates in the 1990s had occurred. The first and latest epidemics were comparatively small-scaled; spreading among the local Chinese MSM while sauna-visiting was found to be the major sex partner sourcing reservoir for the first subtype B epidemic. However, the second epidemic was spread in a large-scale among local Chinese MSM with a number of them having sourced their sex partners through the internet. The epidemic virus was estimated to have a divergence date in 1987 and the infected population in Hong Kong had a logistic growth throughout the past 20 years. Our study elucidated the evolutionary and demographic history of HIV-1 subtype B virus in Hong Kong MSM population. The understanding of transmission and growth model of the subtype B epidemic provides more information on the HIV-1 transmission among MSM population in other Asia Pacific high-income countries. © 2011 Chen et al. | ||||
Persistent Identifier | http://hdl.handle.net/10722/157644 | ||||
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 | ||||
ISI Accession Number ID |
Funding Information: This study was supported by the AIDS Trust Fund of Hong Kong Special Administrative Region Government (MSS-155R and MSS-164R). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, JHK | en_US |
dc.contributor.author | Wong, KH | en_US |
dc.contributor.author | Chan, KCW | en_US |
dc.contributor.author | To, SWC | en_US |
dc.contributor.author | Chen, Z | en_US |
dc.contributor.author | Yam, WC | en_US |
dc.date.accessioned | 2012-08-08T08:51:54Z | - |
dc.date.available | 2012-08-08T08:51:54Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | PLoS One, 2011, v. 6 n. 9, article no. e25286 | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/157644 | - |
dc.description.abstract | The men-having-sex-with-men (MSM) population has become one of the major risk groups for HIV-1 infection in the Asia Pacific countries. Hong Kong is located in the centre of Asia and the transmission history of HIV-1 subtype B transmission among MSM remained unclear. The aim of this study was to investigate the transmission dynamics of HIV-1 subtype B virus in the Hong Kong MSM population. Samples of 125 HIV-1 subtype B infected MSM patients were recruited in this study. Through this study, the subtype B epidemic in the Hong Kong MSM population was identified spreading mainly among local Chinese who caught infection locally. On the other hand, HIV-1 subtype B infected Caucasian MSM caught infection mainly outside Hong Kong. The Bayesian phylogenetic analysis also indicated that 3 separate subtype B epidemics with divergence dates in the 1990s had occurred. The first and latest epidemics were comparatively small-scaled; spreading among the local Chinese MSM while sauna-visiting was found to be the major sex partner sourcing reservoir for the first subtype B epidemic. However, the second epidemic was spread in a large-scale among local Chinese MSM with a number of them having sourced their sex partners through the internet. The epidemic virus was estimated to have a divergence date in 1987 and the infected population in Hong Kong had a logistic growth throughout the past 20 years. Our study elucidated the evolutionary and demographic history of HIV-1 subtype B virus in Hong Kong MSM population. The understanding of transmission and growth model of the subtype B epidemic provides more information on the HIV-1 transmission among MSM population in other Asia Pacific high-income countries. © 2011 Chen et al. | en_US |
dc.language | eng | en_US |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | en_US |
dc.relation.ispartof | PLoS ONE | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chen, Z:zchenai@hkucc.hku.hk | en_US |
dc.identifier.email | Yam, WC:wcyam@hkucc.hku.hk | en_US |
dc.identifier.authority | Chen, Z=rp00243 | en_US |
dc.identifier.authority | Yam, WC=rp00313 | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.identifier.doi | 10.1371/journal.pone.0025286 | en_US |
dc.identifier.scopus | eid_2-s2.0-80053068047 | en_US |
dc.identifier.hkuros | 206294 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053068047&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.isi | WOS:000295265100081 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Chen, JHK=35085819900 | en_US |
dc.identifier.scopusauthorid | Wong, KH=7404758411 | en_US |
dc.identifier.scopusauthorid | Chan, KCW=35097079800 | en_US |
dc.identifier.scopusauthorid | To, SWC=36638680200 | en_US |
dc.identifier.scopusauthorid | Chen, Z=35271180800 | en_US |
dc.identifier.scopusauthorid | Yam, WC=7004281720 | en_US |
dc.identifier.issnl | 1932-6203 | - |