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Article: Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong

TitlePhylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2011, v. 6 n. 9, article no. e25286 How to Cite?
AbstractThe men-having-sex-with-men (MSM) population has become one of the major risk groups for HIV-1 infection in the Asia Pacific countries. Hong Kong is located in the centre of Asia and the transmission history of HIV-1 subtype B transmission among MSM remained unclear. The aim of this study was to investigate the transmission dynamics of HIV-1 subtype B virus in the Hong Kong MSM population. Samples of 125 HIV-1 subtype B infected MSM patients were recruited in this study. Through this study, the subtype B epidemic in the Hong Kong MSM population was identified spreading mainly among local Chinese who caught infection locally. On the other hand, HIV-1 subtype B infected Caucasian MSM caught infection mainly outside Hong Kong. The Bayesian phylogenetic analysis also indicated that 3 separate subtype B epidemics with divergence dates in the 1990s had occurred. The first and latest epidemics were comparatively small-scaled; spreading among the local Chinese MSM while sauna-visiting was found to be the major sex partner sourcing reservoir for the first subtype B epidemic. However, the second epidemic was spread in a large-scale among local Chinese MSM with a number of them having sourced their sex partners through the internet. The epidemic virus was estimated to have a divergence date in 1987 and the infected population in Hong Kong had a logistic growth throughout the past 20 years. Our study elucidated the evolutionary and demographic history of HIV-1 subtype B virus in Hong Kong MSM population. The understanding of transmission and growth model of the subtype B epidemic provides more information on the HIV-1 transmission among MSM population in other Asia Pacific high-income countries. © 2011 Chen et al.
Persistent Identifierhttp://hdl.handle.net/10722/157644
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
Funding AgencyGrant Number
AIDS Trust of Hong Kong Special Administrative Region GovernmentMSS-155R
MSS-164R
Funding Information:

This study was supported by the AIDS Trust Fund of Hong Kong Special Administrative Region Government (MSS-155R and MSS-164R). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorChen, JHKen_US
dc.contributor.authorWong, KHen_US
dc.contributor.authorChan, KCWen_US
dc.contributor.authorTo, SWCen_US
dc.contributor.authorChen, Zen_US
dc.contributor.authorYam, WCen_US
dc.date.accessioned2012-08-08T08:51:54Z-
dc.date.available2012-08-08T08:51:54Z-
dc.date.issued2011en_US
dc.identifier.citationPLoS One, 2011, v. 6 n. 9, article no. e25286en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/157644-
dc.description.abstractThe men-having-sex-with-men (MSM) population has become one of the major risk groups for HIV-1 infection in the Asia Pacific countries. Hong Kong is located in the centre of Asia and the transmission history of HIV-1 subtype B transmission among MSM remained unclear. The aim of this study was to investigate the transmission dynamics of HIV-1 subtype B virus in the Hong Kong MSM population. Samples of 125 HIV-1 subtype B infected MSM patients were recruited in this study. Through this study, the subtype B epidemic in the Hong Kong MSM population was identified spreading mainly among local Chinese who caught infection locally. On the other hand, HIV-1 subtype B infected Caucasian MSM caught infection mainly outside Hong Kong. The Bayesian phylogenetic analysis also indicated that 3 separate subtype B epidemics with divergence dates in the 1990s had occurred. The first and latest epidemics were comparatively small-scaled; spreading among the local Chinese MSM while sauna-visiting was found to be the major sex partner sourcing reservoir for the first subtype B epidemic. However, the second epidemic was spread in a large-scale among local Chinese MSM with a number of them having sourced their sex partners through the internet. The epidemic virus was estimated to have a divergence date in 1987 and the infected population in Hong Kong had a logistic growth throughout the past 20 years. Our study elucidated the evolutionary and demographic history of HIV-1 subtype B virus in Hong Kong MSM population. The understanding of transmission and growth model of the subtype B epidemic provides more information on the HIV-1 transmission among MSM population in other Asia Pacific high-income countries. © 2011 Chen et al.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePhylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.identifier.authorityYam, WC=rp00313en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0025286en_US
dc.identifier.scopuseid_2-s2.0-80053068047en_US
dc.identifier.hkuros206294-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053068047&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue9en_US
dc.identifier.isiWOS:000295265100081-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, JHK=35085819900en_US
dc.identifier.scopusauthoridWong, KH=7404758411en_US
dc.identifier.scopusauthoridChan, KCW=35097079800en_US
dc.identifier.scopusauthoridTo, SWC=36638680200en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US
dc.identifier.scopusauthoridYam, WC=7004281720en_US

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