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Article: T-spot.TB outperforms tuberculin skin test in predicting tuberculosis disease

TitleT-spot.TB outperforms tuberculin skin test in predicting tuberculosis disease
Authors
KeywordsIfn-Γ Release Assay
Latent Tuberculosis Infection
Silicosis
Issue Date2010
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Journal Of Respiratory And Critical Care Medicine, 2010, v. 182 n. 6, p. 834-840 How to Cite?
Abstract
Rationale: Silicosis is a well-recognized risk factor for tuberculosis (TB). Objectives: To compare T-Spot.TB with tuberculin skin test (TST) in predicting the development of TB. Methods:Male patients with silicosis without clinical suspicion of active TB, past history of TB, and treatment for latent TB infection (LTBI) were offered both T-Spot. TB and TST in the Pneumoconiosis Clinic of Hong Kong from 2004 to 2008, and followed prospectively until September 30, 2009, for development of TB. Measurements and Main Results: Active TB and culture- or histology-confirmed TB developed in 17 (5.5%) and 14 (4.5%) of 308 recruited subjects at an annual rate of 2,247 and 1,851 per 100,000 person-years, respectively. Active TB occurred in 7.4% (15 of 204) and 1.9% (2 of 104) of T-Spot. TB-positive and-negative subjects, respectively, whereas the corresponding figures for TST (cutoff 10 mm) were 6.4% (13 of 203) and 3.9% (4 of 205), respectively. Apositive T-Spot. TB test significantly predicted the subsequent development of active TB (relative risk, 4.50; 95% confidence interval, 1.03-19.68) and culture- or histology-confirmed TB (relative risk, 7.80; 95% confidence interval, 1.02-59.63). Consistent results were obtained after exclusion of subjects treated for LTBI and adjustment for potential confounders. TST did not significantly predict the development of active TB or culture- or histology-confirmed TB, irrespective of the cutoff values with or without exclusion of subjects treated for LTBI. Culture filtrate protein 10 spot count, but not early secretary antigenic target 6 spot count, was significantly associated with subsequent TB development. Conclusions: T-Spot. TB performs better than TST in the targeted screening of LTBI among patients with silicosis.
Persistent Identifierhttp://hdl.handle.net/10722/157605
ISSN
2013 Impact Factor: 11.986
ISI Accession Number ID
Funding AgencyGrant Number
Pneumoconiosis Compensation Fund Board
University of Hong Kong
Funding Information:

Supported by research grants from the Pneumoconiosis Compensation Fund Board and from the University of Hong Kong UDF Project-Research Centre of Emerging Infection Diseases.

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Centre for Health Protection
  3. Grantham Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorLeung, CCen_US
dc.contributor.authorYam, WCen_US
dc.contributor.authorYew, WWen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorTam, CMen_US
dc.contributor.authorLaw, WSen_US
dc.contributor.authorAu, KFen_US
dc.contributor.authorTsui, PWen_US
dc.date.accessioned2012-08-08T08:51:38Z-
dc.date.available2012-08-08T08:51:38Z-
dc.date.issued2010en_US
dc.identifier.citationAmerican Journal Of Respiratory And Critical Care Medicine, 2010, v. 182 n. 6, p. 834-840en_US
dc.identifier.issn1073-449Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/157605-
dc.description.abstractRationale: Silicosis is a well-recognized risk factor for tuberculosis (TB). Objectives: To compare T-Spot.TB with tuberculin skin test (TST) in predicting the development of TB. Methods:Male patients with silicosis without clinical suspicion of active TB, past history of TB, and treatment for latent TB infection (LTBI) were offered both T-Spot. TB and TST in the Pneumoconiosis Clinic of Hong Kong from 2004 to 2008, and followed prospectively until September 30, 2009, for development of TB. Measurements and Main Results: Active TB and culture- or histology-confirmed TB developed in 17 (5.5%) and 14 (4.5%) of 308 recruited subjects at an annual rate of 2,247 and 1,851 per 100,000 person-years, respectively. Active TB occurred in 7.4% (15 of 204) and 1.9% (2 of 104) of T-Spot. TB-positive and-negative subjects, respectively, whereas the corresponding figures for TST (cutoff 10 mm) were 6.4% (13 of 203) and 3.9% (4 of 205), respectively. Apositive T-Spot. TB test significantly predicted the subsequent development of active TB (relative risk, 4.50; 95% confidence interval, 1.03-19.68) and culture- or histology-confirmed TB (relative risk, 7.80; 95% confidence interval, 1.02-59.63). Consistent results were obtained after exclusion of subjects treated for LTBI and adjustment for potential confounders. TST did not significantly predict the development of active TB or culture- or histology-confirmed TB, irrespective of the cutoff values with or without exclusion of subjects treated for LTBI. Culture filtrate protein 10 spot count, but not early secretary antigenic target 6 spot count, was significantly associated with subsequent TB development. Conclusions: T-Spot. TB performs better than TST in the targeted screening of LTBI among patients with silicosis.en_US
dc.languageengen_US
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_US
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicineen_US
dc.subjectIfn-Γ Release Assayen_US
dc.subjectLatent Tuberculosis Infectionen_US
dc.subjectSilicosisen_US
dc.titleT-spot.TB outperforms tuberculin skin test in predicting tuberculosis diseaseen_US
dc.typeArticleen_US
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.authorityYam, WC=rp00313en_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1164/rccm.200912-1875OCen_US
dc.identifier.pmid20508217-
dc.identifier.scopuseid_2-s2.0-77957069528en_US
dc.identifier.hkuros179786-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957069528&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume182en_US
dc.identifier.issue6en_US
dc.identifier.spage834en_US
dc.identifier.epage840en_US
dc.identifier.isiWOS:000282162100017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, CC=7402612644en_US
dc.identifier.scopusauthoridYam, WC=7004281720en_US
dc.identifier.scopusauthoridYew, WW=7005934631en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridTam, CM=7201442997en_US
dc.identifier.scopusauthoridLaw, WS=7103147875en_US
dc.identifier.scopusauthoridAu, KF=35763716800en_US
dc.identifier.scopusauthoridTsui, PW=36549504200en_US

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