Article: Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China

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TitleIdentification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
AuthorsLau, SKP2
Woo, PCY2
Wong, BHL2
Wong, AYP2
Tsoi, HW2
Wang, M1
Lee, P2
Xu, H1
Poon, RWS2
Guo, R1
Li, KSM2
Chan, KH2
Zheng, BJ2
Yuen, KY2
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
CitationVirology, 2010, v. 404 n. 1, p. 106-116 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.virol.2010.03.049
AbstractAmong 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are unique by possessing GA instead of AG at the 5th and 6th positions. Unlike Menangle and Tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attachment proteins are present. The genome of ThkPV-1 represents the largest rubulavirus genome. Unique features between the three viruses include perfect complementary 5'-trailer and 3'-leader sequence and a unique cysteine pair in attachment protein of ThkPV-1, G at +. 1 position in all predicted mRNA sequences of ThkPV-2, and amino acid substitutions in the conserved N-terminal motif of nucleocapsid of ThkPV-3. Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes. © 2010 Elsevier Inc.
ISSN0042-6822
2011 Impact Factor: 3.351
2011 SCImago Journal Rankings: 0.355
DOIhttp://dx.doi.org/10.1016/j.virol.2010.03.049
ISI Accession Number IDWOS:000278958000012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLau, SKP
dc.contributor.authorWoo, PCY
dc.contributor.authorWong, BHL
dc.contributor.authorWong, AYP
dc.contributor.authorTsoi, HW
dc.contributor.authorWang, M
dc.contributor.authorLee, P
dc.contributor.authorXu, H
dc.contributor.authorPoon, RWS
dc.contributor.authorGuo, R
dc.contributor.authorLi, KSM
dc.contributor.authorChan, KH
dc.contributor.authorZheng, BJ
dc.contributor.authorYuen, KY
dc.date.accessioned2012-08-08T08:51:32Z
dc.date.available2012-08-08T08:51:32Z
dc.date.issued2010
dc.description.abstractAmong 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are unique by possessing GA instead of AG at the 5th and 6th positions. Unlike Menangle and Tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attachment proteins are present. The genome of ThkPV-1 represents the largest rubulavirus genome. Unique features between the three viruses include perfect complementary 5'-trailer and 3'-leader sequence and a unique cysteine pair in attachment protein of ThkPV-1, G at +. 1 position in all predicted mRNA sequences of ThkPV-2, and amino acid substitutions in the conserved N-terminal motif of nucleocapsid of ThkPV-3. Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes. © 2010 Elsevier Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationVirology, 2010, v. 404 n. 1, p. 106-116 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.virol.2010.03.049
dc.identifier.citeulike7400831
dc.identifier.doihttp://dx.doi.org/10.1016/j.virol.2010.03.049
dc.identifier.epage116
dc.identifier.isiWOS:000278958000012
dc.identifier.issn0042-6822
2011 Impact Factor: 3.351
2011 SCImago Journal Rankings: 0.355
dc.identifier.issue1
dc.identifier.pmid20537670
dc.identifier.scopuseid_2-s2.0-77953707374
dc.identifier.spage106
dc.identifier.urihttp://hdl.handle.net/10722/157591
dc.identifier.volume404
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
dc.publisher.placeUnited States
dc.relation.ispartofVirology
dc.relation.referencesReferences in Scopus
dc.subject.mesh3' Untranslated Regions
dc.subject.meshAmino Acid Substitution - Genetics
dc.subject.meshAnimals
dc.subject.meshChina
dc.subject.meshChiroptera - Virology
dc.subject.meshCluster Analysis
dc.subject.meshGenome, Viral
dc.subject.meshMolecular Sequence Data
dc.subject.meshParamyxoviridae - Classification - Genetics - Isolation & Purification
dc.subject.meshParamyxoviridae Infections - Veterinary - Virology
dc.subject.meshPhylogeny
dc.subject.meshRna, Viral - Genetics
dc.subject.meshSequence Analysis, Dna
dc.subject.meshViral Proteins - Genetics
dc.titleIdentification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
dc.typeArticle
Author Affiliations
  1. Guangdong Center for Disease Control and Prevention
  2. The University of Hong Kong