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Article: Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China

TitleIdentification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
Authors
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2010, v. 404 n. 1, p. 106-116 How to Cite?
Abstract
Among 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are unique by possessing GA instead of AG at the 5th and 6th positions. Unlike Menangle and Tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attachment proteins are present. The genome of ThkPV-1 represents the largest rubulavirus genome. Unique features between the three viruses include perfect complementary 5'-trailer and 3'-leader sequence and a unique cysteine pair in attachment protein of ThkPV-1, G at +. 1 position in all predicted mRNA sequences of ThkPV-2, and amino acid substitutions in the conserved N-terminal motif of nucleocapsid of ThkPV-3. Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/157591
ISSN
2013 Impact Factor: 3.278
ISI Accession Number ID
References

 

Author Affiliations
  1. Guangdong Center for Disease Control and Prevention
  2. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLau, SKPen_US
dc.contributor.authorWoo, PCYen_US
dc.contributor.authorWong, BHLen_US
dc.contributor.authorWong, AYPen_US
dc.contributor.authorTsoi, HWen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorLee, Pen_US
dc.contributor.authorXu, Hen_US
dc.contributor.authorPoon, RWSen_US
dc.contributor.authorGuo, Ren_US
dc.contributor.authorLi, KSMen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorZheng, BJen_US
dc.contributor.authorYuen, KYen_US
dc.date.accessioned2012-08-08T08:51:32Z-
dc.date.available2012-08-08T08:51:32Z-
dc.date.issued2010en_US
dc.identifier.citationVirology, 2010, v. 404 n. 1, p. 106-116en_US
dc.identifier.issn0042-6822en_US
dc.identifier.urihttp://hdl.handle.net/10722/157591-
dc.description.abstractAmong 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are unique by possessing GA instead of AG at the 5th and 6th positions. Unlike Menangle and Tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attachment proteins are present. The genome of ThkPV-1 represents the largest rubulavirus genome. Unique features between the three viruses include perfect complementary 5'-trailer and 3'-leader sequence and a unique cysteine pair in attachment protein of ThkPV-1, G at +. 1 position in all predicted mRNA sequences of ThkPV-2, and amino acid substitutions in the conserved N-terminal motif of nucleocapsid of ThkPV-3. Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes. © 2010 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_US
dc.relation.ispartofVirologyen_US
dc.subject.mesh3' Untranslated Regionsen_US
dc.subject.meshAmino Acid Substitution - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChinaen_US
dc.subject.meshChiroptera - Virologyen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshParamyxoviridae - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshParamyxoviridae Infections - Veterinary - Virologyen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshRna, Viral - Geneticsen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshViral Proteins - Geneticsen_US
dc.titleIdentification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from Chinaen_US
dc.typeArticleen_US
dc.identifier.emailLau, SKP:skplau@hkucc.hku.hken_US
dc.identifier.emailWoo, PCY:pcywoo@hkucc.hku.hken_US
dc.identifier.emailTsoi, HW:hwtsoi@hkucc.hku.hken_US
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityLau, SKP=rp00486en_US
dc.identifier.authorityWoo, PCY=rp00430en_US
dc.identifier.authorityTsoi, HW=rp00439en_US
dc.identifier.authorityZheng, BJ=rp00353en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.virol.2010.03.049en_US
dc.identifier.pmid20537670en_US
dc.identifier.scopuseid_2-s2.0-77953707374en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953707374&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume404en_US
dc.identifier.issue1en_US
dc.identifier.spage106en_US
dc.identifier.epage116en_US
dc.identifier.isiWOS:000278958000012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, SKP=7401596211en_US
dc.identifier.scopusauthoridWoo, PCY=7201801340en_US
dc.identifier.scopusauthoridWong, BHL=7402023413en_US
dc.identifier.scopusauthoridWong, AYP=53464494100en_US
dc.identifier.scopusauthoridTsoi, HW=6603822102en_US
dc.identifier.scopusauthoridWang, M=7406685232en_US
dc.identifier.scopusauthoridLee, P=36189338700en_US
dc.identifier.scopusauthoridXu, H=7407448207en_US
dc.identifier.scopusauthoridPoon, RWS=9334879200en_US
dc.identifier.scopusauthoridGuo, R=15839273700en_US
dc.identifier.scopusauthoridLi, KSM=24759122500en_US
dc.identifier.scopusauthoridChan, KH=7406034307en_US
dc.identifier.scopusauthoridZheng, BJ=7201780588en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.citeulike7400831-

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