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Article: Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
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TitleIdentification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
 
AuthorsLau, SKP2
Woo, PCY2
Wong, BHL2
Wong, AYP2
Tsoi, HW2
Wang, M1
Lee, P2
Xu, H1
Poon, RWS2
Guo, R1
Li, KSM2
Chan, KH2
Zheng, BJ2
Yuen, KY2
 
Issue Date2010
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
 
CitationVirology, 2010, v. 404 n. 1, p. 106-116 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.virol.2010.03.049
 
AbstractAmong 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are unique by possessing GA instead of AG at the 5th and 6th positions. Unlike Menangle and Tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attachment proteins are present. The genome of ThkPV-1 represents the largest rubulavirus genome. Unique features between the three viruses include perfect complementary 5'-trailer and 3'-leader sequence and a unique cysteine pair in attachment protein of ThkPV-1, G at +. 1 position in all predicted mRNA sequences of ThkPV-2, and amino acid substitutions in the conserved N-terminal motif of nucleocapsid of ThkPV-3. Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes. © 2010 Elsevier Inc.
 
ISSN0042-6822
2013 Impact Factor: 3.278
 
DOIhttp://dx.doi.org/10.1016/j.virol.2010.03.049
 
ISI Accession Number IDWOS:000278958000012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLau, SKP
 
dc.contributor.authorWoo, PCY
 
dc.contributor.authorWong, BHL
 
dc.contributor.authorWong, AYP
 
dc.contributor.authorTsoi, HW
 
dc.contributor.authorWang, M
 
dc.contributor.authorLee, P
 
dc.contributor.authorXu, H
 
dc.contributor.authorPoon, RWS
 
dc.contributor.authorGuo, R
 
dc.contributor.authorLi, KSM
 
dc.contributor.authorChan, KH
 
dc.contributor.authorZheng, BJ
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2012-08-08T08:51:32Z
 
dc.date.available2012-08-08T08:51:32Z
 
dc.date.issued2010
 
dc.description.abstractAmong 489 bats of 11 species in China, three novel paramyxoviruses [Tuhokovirus 1, 2 and 3 (ThkPV-1, ThkPV-2 and ThkPV-3)] were discovered in 15 Leschenault's rousettes. Phylogenetically, the three viruses are most closely related to Menangle and Tioman virus. Genome analysis showed that their 3'-leader sequences are unique by possessing GA instead of AG at the 5th and 6th positions. Unlike Menangle and Tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attachment proteins are present. The genome of ThkPV-1 represents the largest rubulavirus genome. Unique features between the three viruses include perfect complementary 5'-trailer and 3'-leader sequence and a unique cysteine pair in attachment protein of ThkPV-1, G at +. 1 position in all predicted mRNA sequences of ThkPV-2, and amino acid substitutions in the conserved N-terminal motif of nucleocapsid of ThkPV-3. Analysis of phosphoprotein gene mRNA products confirmed mRNA editing. Antibodies to the viruses were detected in 48-60% of Leschenault's rousettes. © 2010 Elsevier Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationVirology, 2010, v. 404 n. 1, p. 106-116 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.virol.2010.03.049
 
dc.identifier.citeulike7400831
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.virol.2010.03.049
 
dc.identifier.epage116
 
dc.identifier.isiWOS:000278958000012
 
dc.identifier.issn0042-6822
2013 Impact Factor: 3.278
 
dc.identifier.issue1
 
dc.identifier.pmid20537670
 
dc.identifier.scopuseid_2-s2.0-77953707374
 
dc.identifier.spage106
 
dc.identifier.urihttp://hdl.handle.net/10722/157591
 
dc.identifier.volume404
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
 
dc.publisher.placeUnited States
 
dc.relation.ispartofVirology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.mesh3' Untranslated Regions
 
dc.subject.meshAmino Acid Substitution - Genetics
 
dc.subject.meshAnimals
 
dc.subject.meshChina
 
dc.subject.meshChiroptera - Virology
 
dc.subject.meshCluster Analysis
 
dc.subject.meshGenome, Viral
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshParamyxoviridae - Classification - Genetics - Isolation & Purification
 
dc.subject.meshParamyxoviridae Infections - Veterinary - Virology
 
dc.subject.meshPhylogeny
 
dc.subject.meshRna, Viral - Genetics
 
dc.subject.meshSequence Analysis, Dna
 
dc.subject.meshViral Proteins - Genetics
 
dc.titleIdentification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China
 
dc.typeArticle
 
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Author Affiliations
  1. Guangdong Center for Disease Control and Prevention
  2. The University of Hong Kong