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Article: Fecal carriage of CTXM type extended-spectrum beta-lactamase-producing organisms by children and their household contacts

TitleFecal carriage of CTXM type extended-spectrum beta-lactamase-producing organisms by children and their household contacts
Authors
KeywordsColonization
Extended-spectrum beta-lactamases
Molecular epidemiology
Risk factors
Issue Date2010
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinf
Citation
Journal Of Infection, 2010, v. 60 n. 4, p. 286-292 How to Cite?
AbstractObjectives: To investigate the epidemiology of fecal carriage of CTX-M type extended-spectrum beta-lactamases (ESBL)-producing organisms among children and their household contacts. Methods: Fecal carriage with CTX-M-producing organisms was studied in 53 children and 172 household members. Molecular methods were used to characterize the isolates. Results: The children were mostly healthy and hospitalized for relatively mild febrile illnesses. Overall, the prevalence of fecal carriage of CTX-M-producing bacteria was 43.5% (admission children, 37.7%; household children, 20.7% and household adults, 50.3%). Household colonization index (defined by number of household carriers/total number of members) was significantly higher among families with at least one individual having a history of prolonged (>3months) out-of-town residence in the previous year (mean ± standard deviation; yes group, 0.67 ± 0.36 vs. no group, 0.39 ± 0.28, P=. 0.009) and was inversely correlated with the living space per person (R-square = 0.139, P = 0.006). Among 29 households with at least two carriers of CTX-M-producing enterobacteria, six clusters of clonally related strains were shared by 15 individuals from seven households; with both intra- and inter-household transmission. Conclusion: CTX-M beta-lactamases may spread extensively amongst family members in the home. © 2010 The British Infection Society.
Persistent Identifierhttp://hdl.handle.net/10722/157586
ISSN
2015 Impact Factor: 4.382
2015 SCImago Journal Rankings: 2.070
ISI Accession Number ID
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases (RFCID) of the Health
Welfare and Food Bureau of the Hong Kong
Funding Information:

The work is supported by research grants from the Research Fund for the Control of Infectious Diseases (RFCID) of the Health, Welfare and Food Bureau of the Hong Kong SAR Government and from the UDF Project-Research Centre of Emerging Infectious Diseases.

References

 

DC FieldValueLanguage
dc.contributor.authorLo, WUen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChow, KHen_HK
dc.contributor.authorLai, ELen_HK
dc.contributor.authorYeung, Fen_HK
dc.contributor.authorChiu, SSen_HK
dc.date.accessioned2012-08-08T08:51:29Z-
dc.date.available2012-08-08T08:51:29Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Infection, 2010, v. 60 n. 4, p. 286-292en_HK
dc.identifier.issn0163-4453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157586-
dc.description.abstractObjectives: To investigate the epidemiology of fecal carriage of CTX-M type extended-spectrum beta-lactamases (ESBL)-producing organisms among children and their household contacts. Methods: Fecal carriage with CTX-M-producing organisms was studied in 53 children and 172 household members. Molecular methods were used to characterize the isolates. Results: The children were mostly healthy and hospitalized for relatively mild febrile illnesses. Overall, the prevalence of fecal carriage of CTX-M-producing bacteria was 43.5% (admission children, 37.7%; household children, 20.7% and household adults, 50.3%). Household colonization index (defined by number of household carriers/total number of members) was significantly higher among families with at least one individual having a history of prolonged (>3months) out-of-town residence in the previous year (mean ± standard deviation; yes group, 0.67 ± 0.36 vs. no group, 0.39 ± 0.28, P=. 0.009) and was inversely correlated with the living space per person (R-square = 0.139, P = 0.006). Among 29 households with at least two carriers of CTX-M-producing enterobacteria, six clusters of clonally related strains were shared by 15 individuals from seven households; with both intra- and inter-household transmission. Conclusion: CTX-M beta-lactamases may spread extensively amongst family members in the home. © 2010 The British Infection Society.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jinfen_HK
dc.relation.ispartofJournal of Infectionen_HK
dc.subjectColonizationen_HK
dc.subjectExtended-spectrum beta-lactamasesen_HK
dc.subjectMolecular epidemiologyen_HK
dc.subjectRisk factorsen_HK
dc.titleFecal carriage of CTXM type extended-spectrum beta-lactamase-producing organisms by children and their household contactsen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailChow, KH:khchowb@hku.hken_HK
dc.identifier.emailChiu, SS:ssschiu@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityChow, KH=rp00370en_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jinf.2010.02.002en_HK
dc.identifier.scopuseid_2-s2.0-77952574674en_HK
dc.identifier.hkuros169768-
dc.identifier.hkuros219368-
dc.identifier.hkuros220706-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952574674&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue4en_HK
dc.identifier.spage286en_HK
dc.identifier.epage292en_HK
dc.identifier.isiWOS:000275789100005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLo, WU=35558916700en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChow, KH=7202180736en_HK
dc.identifier.scopusauthoridLai, EL=8238477100en_HK
dc.identifier.scopusauthoridYeung, F=35560057200en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK

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