File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: An oral mucosal DNA vaccine for SARS coronavirus infections.

TitleAn oral mucosal DNA vaccine for SARS coronavirus infections.
Authors
Issue Date2009
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 2, p. 41-42 How to Cite?
Abstract1. When different forms of SARS coronavirus (SARS-CoV) spike protein-based vaccines for generation of a neutralising antibody response to SARS-CoV were injected into a mouse model, all the mice immunised with intramuscular tPA-optimised 800 DNA vaccine boosted with intraperitoneal recombinant spike polypeptide generated by Escherichia coli and intramuscular CTLA4Hinge SARS800 DNA vaccine boosted with intraperitoneal S-peptide had neutralising antibody titres of>1:1280.2. This observation may have major practical value for field studies, such as the immunisation of civet cats, as the cost of recombinant proteins produced by E coli is much lower than those produced by eukaryotic systems.3. This study indicates that the type of vaccine used for priming is crucial for determining the type of immune response developed.Subsequent doses will boost the immune response generated by the first dose of vaccine.
Persistent Identifierhttp://hdl.handle.net/10722/157573
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorYuen, KYen_US
dc.contributor.authorWoo, PCen_US
dc.contributor.authorLau, SKen_US
dc.date.accessioned2012-08-08T08:51:23Z-
dc.date.available2012-08-08T08:51:23Z-
dc.date.issued2009en_US
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 2, p. 41-42en_US
dc.identifier.issn1024-2708en_US
dc.identifier.urihttp://hdl.handle.net/10722/157573-
dc.description.abstract1. When different forms of SARS coronavirus (SARS-CoV) spike protein-based vaccines for generation of a neutralising antibody response to SARS-CoV were injected into a mouse model, all the mice immunised with intramuscular tPA-optimised 800 DNA vaccine boosted with intraperitoneal recombinant spike polypeptide generated by Escherichia coli and intramuscular CTLA4Hinge SARS800 DNA vaccine boosted with intraperitoneal S-peptide had neutralising antibody titres of>1:1280.2. This observation may have major practical value for field studies, such as the immunisation of civet cats, as the cost of recombinant proteins produced by E coli is much lower than those produced by eukaryotic systems.3. This study indicates that the type of vaccine used for priming is crucial for determining the type of immune response developed.Subsequent doses will boost the immune response generated by the first dose of vaccine.en_US
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_US
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Viral - Immunologyen_US
dc.subject.meshEscherichia Coli Proteins - Immunologyen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshMembrane Glycoproteins - Administration & Dosage - Immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMouth Mucosa - Metabolismen_US
dc.subject.meshSars Virus - Immunologyen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Immunology - Prevention & Controlen_US
dc.subject.meshVaccines, Dna - Administration & Dosage - Immunologyen_US
dc.subject.meshViral Envelope Proteins - Administration & Dosage - Immunologyen_US
dc.subject.meshViral Vaccines - Administration & Dosage - Immunologyen_US
dc.titleAn oral mucosal DNA vaccine for SARS coronavirus infections.en_US
dc.typeArticleen_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.emailWoo, PC:pcywoo@hkucc.hku.hken_US
dc.identifier.emailLau, SK:skplau@hkucc.hku.hken_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.identifier.authorityWoo, PC=rp00430en_US
dc.identifier.authorityLau, SK=rp00486en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid19258634-
dc.identifier.scopuseid_2-s2.0-73349115240en_US
dc.identifier.volume15 Suppl 2en_US
dc.identifier.spage41en_US
dc.identifier.epage42en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridWoo, PC=7201801340en_US
dc.identifier.scopusauthoridLau, SK=7401596211en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats