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- Scopus: eid_2-s2.0-73349115240
- PMID: 19258634
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Article: An oral mucosal DNA vaccine for SARS coronavirus infections.
Title | An oral mucosal DNA vaccine for SARS coronavirus infections. |
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Authors | |
Issue Date | 2009 |
Publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html |
Citation | Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 2, p. 41-42 How to Cite? |
Abstract | 1. When different forms of SARS coronavirus (SARS-CoV) spike protein-based vaccines for generation of a neutralising antibody response to SARS-CoV were injected into a mouse model, all the mice immunised with intramuscular tPA-optimised 800 DNA vaccine boosted with intraperitoneal recombinant spike polypeptide generated by Escherichia coli and intramuscular CTLA4Hinge SARS800 DNA vaccine boosted with intraperitoneal S-peptide had neutralising antibody titres of>1:1280.2. This observation may have major practical value for field studies, such as the immunisation of civet cats, as the cost of recombinant proteins produced by E coli is much lower than those produced by eukaryotic systems.3. This study indicates that the type of vaccine used for priming is crucial for determining the type of immune response developed.Subsequent doses will boost the immune response generated by the first dose of vaccine. |
Persistent Identifier | http://hdl.handle.net/10722/157573 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
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dc.contributor.author | Yuen, KY | en_US |
dc.contributor.author | Woo, PC | en_US |
dc.contributor.author | Lau, SK | en_US |
dc.date.accessioned | 2012-08-08T08:51:23Z | - |
dc.date.available | 2012-08-08T08:51:23Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 2, p. 41-42 | en_US |
dc.identifier.issn | 1024-2708 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/157573 | - |
dc.description.abstract | 1. When different forms of SARS coronavirus (SARS-CoV) spike protein-based vaccines for generation of a neutralising antibody response to SARS-CoV were injected into a mouse model, all the mice immunised with intramuscular tPA-optimised 800 DNA vaccine boosted with intraperitoneal recombinant spike polypeptide generated by Escherichia coli and intramuscular CTLA4Hinge SARS800 DNA vaccine boosted with intraperitoneal S-peptide had neutralising antibody titres of>1:1280.2. This observation may have major practical value for field studies, such as the immunisation of civet cats, as the cost of recombinant proteins produced by E coli is much lower than those produced by eukaryotic systems.3. This study indicates that the type of vaccine used for priming is crucial for determining the type of immune response developed.Subsequent doses will boost the immune response generated by the first dose of vaccine. | en_US |
dc.language | eng | en_US |
dc.publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html | en_US |
dc.relation.ispartof | Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine | en_US |
dc.subject.mesh | Administration, Oral | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antibodies, Viral - Immunology | en_US |
dc.subject.mesh | Escherichia Coli Proteins - Immunology | en_US |
dc.subject.mesh | Injections, Intramuscular | en_US |
dc.subject.mesh | Membrane Glycoproteins - Administration & Dosage - Immunology | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mouth Mucosa - Metabolism | en_US |
dc.subject.mesh | Sars Virus - Immunology | en_US |
dc.subject.mesh | Severe Acute Respiratory Syndrome - Immunology - Prevention & Control | en_US |
dc.subject.mesh | Vaccines, Dna - Administration & Dosage - Immunology | en_US |
dc.subject.mesh | Viral Envelope Proteins - Administration & Dosage - Immunology | en_US |
dc.subject.mesh | Viral Vaccines - Administration & Dosage - Immunology | en_US |
dc.title | An oral mucosal DNA vaccine for SARS coronavirus infections. | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yuen, KY:kyyuen@hkucc.hku.hk | en_US |
dc.identifier.email | Woo, PC:pcywoo@hkucc.hku.hk | en_US |
dc.identifier.email | Lau, SK:skplau@hkucc.hku.hk | en_US |
dc.identifier.authority | Yuen, KY=rp00366 | en_US |
dc.identifier.authority | Woo, PC=rp00430 | en_US |
dc.identifier.authority | Lau, SK=rp00486 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 19258634 | - |
dc.identifier.scopus | eid_2-s2.0-73349115240 | en_US |
dc.identifier.volume | 15 Suppl 2 | en_US |
dc.identifier.spage | 41 | en_US |
dc.identifier.epage | 42 | en_US |
dc.publisher.place | Hong Kong | en_US |
dc.identifier.scopusauthorid | Yuen, KY=36078079100 | en_US |
dc.identifier.scopusauthorid | Woo, PC=7201801340 | en_US |
dc.identifier.scopusauthorid | Lau, SK=7401596211 | en_US |
dc.identifier.issnl | 1024-2708 | - |