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Article: A 7-year-old boy dying of acute encephalopathy: Com august 2009 case 1

TitleA 7-year-old boy dying of acute encephalopathy: Com august 2009 case 1
Authors
Issue Date2010
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1015-6305&site=1
Citation
Brain Pathology, 2010, v. 20 n. 1, p. 261-264 How to Cite?
AbstractA 7 year old Chinese boy died of a rapidly progressive encephalopathy after influenza infection. MRI showed bilateral and symmetrical lesions including the thalamus and brainstem tegmentum. The pathology of necrosis and vasculopathy were in keeping with acute necrotizing encephalopathy (ANE). ANE was first described in Japan and carries a high mortality and morbidity. A vasculopathy with breakdown of the blood-brain-barrier was incriminated but the pathogenesis remained obscure and autopsy studies have been limited. A review of the literature showed only nine postmortem reports in the acute stage. Symmetrical brain necrosis always involved the thalamus followed by the tegmentum of the pons and other regions. Exudative vasculopathy was commonly observed and often accompanied by endothelial cell necrosis. In the present case there was inflammatory fibrinoid vasculitis which has not been previously described. © 2010 International Society of Neuropathology.
Persistent Identifierhttp://hdl.handle.net/10722/157569
ISSN
2015 Impact Factor: 5.256
2015 SCImago Journal Rankings: 2.092
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, WFen_US
dc.contributor.authorChiu, SCen_US
dc.contributor.authorLam, DSYen_US
dc.contributor.authorWong, YCen_US
dc.contributor.authorTam, Sen_US
dc.contributor.authorKwong, NSen_US
dc.contributor.authorLoo, KTen_US
dc.contributor.authorYuen, KYen_US
dc.date.accessioned2012-08-08T08:51:21Z-
dc.date.available2012-08-08T08:51:21Z-
dc.date.issued2010en_US
dc.identifier.citationBrain Pathology, 2010, v. 20 n. 1, p. 261-264en_US
dc.identifier.issn1015-6305en_US
dc.identifier.urihttp://hdl.handle.net/10722/157569-
dc.description.abstractA 7 year old Chinese boy died of a rapidly progressive encephalopathy after influenza infection. MRI showed bilateral and symmetrical lesions including the thalamus and brainstem tegmentum. The pathology of necrosis and vasculopathy were in keeping with acute necrotizing encephalopathy (ANE). ANE was first described in Japan and carries a high mortality and morbidity. A vasculopathy with breakdown of the blood-brain-barrier was incriminated but the pathogenesis remained obscure and autopsy studies have been limited. A review of the literature showed only nine postmortem reports in the acute stage. Symmetrical brain necrosis always involved the thalamus followed by the tegmentum of the pons and other regions. Exudative vasculopathy was commonly observed and often accompanied by endothelial cell necrosis. In the present case there was inflammatory fibrinoid vasculitis which has not been previously described. © 2010 International Society of Neuropathology.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1015-6305&site=1en_US
dc.relation.ispartofBrain Pathologyen_US
dc.subject.meshAsthma - Complicationsen_US
dc.subject.meshBrain Stem - Pathologyen_US
dc.subject.meshCerebellum - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshGlasgow Coma Scaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H1n1 Subtypeen_US
dc.subject.meshInfluenza, Human - Complications - Pathologyen_US
dc.subject.meshLeukoencephalitis, Acute Hemorrhagic - Etiology - Pathologyen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshThalamus - Pathologyen_US
dc.titleA 7-year-old boy dying of acute encephalopathy: Com august 2009 case 1en_US
dc.typeArticleen_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1750-3639.2009.00346.xen_US
dc.identifier.pmid20438486-
dc.identifier.scopuseid_2-s2.0-71549171160en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-71549171160&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.spage261en_US
dc.identifier.epage264en_US
dc.identifier.isiWOS:000272437500024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNg, WF=7401613384en_US
dc.identifier.scopusauthoridChiu, SC=37044601500en_US
dc.identifier.scopusauthoridLam, DSY=12796063000en_US
dc.identifier.scopusauthoridWong, YC=7403040273en_US
dc.identifier.scopusauthoridTam, S=7202037323en_US
dc.identifier.scopusauthoridKwong, NS=12646682000en_US
dc.identifier.scopusauthoridLoo, KT=7003558714en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US

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