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Article: The hemagglutinin structure of an avian H1N1 influenza A virus
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TitleThe hemagglutinin structure of an avian H1N1 influenza A virus
 
AuthorsLin, T2 1
Wang, G4 3
Li, A2
Zhang, Q2
Wu, C2
Zhang, R2
Cai, Q2
Song, W1
Yuen, KY1
 
Issue Date2009
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
 
CitationVirology, 2009, v. 392 n. 1, p. 73-81 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.virol.2009.06.028
 
AbstractThe interaction between hemagglutinin (HA) and receptors is a kernel in the study of evolution and host adaptation of H1N1 influenza A viruses. The notion that the avian HA is associated with preferential specificity for receptors with Siaα2,3Gal glycosidic linkage over those with Siaα2,6Gal linkage is not all consistent with the available data on H1N1 viruses. By x-ray crystallography, the HA structure of an avian H1N1 influenza A virus, as well as its complexes with the receptor analogs, was determined. The structures revealed no preferential binding of avian receptor analogs over that of the human analog, suggesting that the HA/receptor binding might not be as stringent as is commonly believed in determining the host receptor preference for some subtypes of influenza viruses, such as the H1N1 viruses. The structure also showed difference in glycosylation despite the preservation of related sequences, which may partly contribute to the difference between structures of human and avian origin. © 2009 Elsevier Inc. All rights reserved.
 
ISSN0042-6822
2012 Impact Factor: 3.367
2012 SCImago Journal Rankings: 1.428
 
DOIhttp://dx.doi.org/10.1016/j.virol.2009.06.028
 
ISI Accession Number IDWOS:000269783500008
Funding AgencyGrant Number
National Science Foundation of China30870479
111 Project of ChinaB06016
Providence Foundation Limited
Research Fund for Infections Diseases of Hong Kong SAR
Li Ka Shing Foundation
Funding Information:

Discussions with Drs. Yi Guan and Honglin Chen helped greatly on the research, which are gratefully acknowledged. The authors thank the help from Dr. Vukica Srajer and others at the BioCARS of the Advance Photo Sources for data collection and processing. The work is supported by the National Science Foundation of China (Grant No. 30870479), the 111 Project of China No. B06016), the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh, the Research Fund for Infections Diseases of Hong Kong SAR, and the Li Ka Shing Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLin, T
 
dc.contributor.authorWang, G
 
dc.contributor.authorLi, A
 
dc.contributor.authorZhang, Q
 
dc.contributor.authorWu, C
 
dc.contributor.authorZhang, R
 
dc.contributor.authorCai, Q
 
dc.contributor.authorSong, W
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2012-08-08T08:51:14Z
 
dc.date.available2012-08-08T08:51:14Z
 
dc.date.issued2009
 
dc.description.abstractThe interaction between hemagglutinin (HA) and receptors is a kernel in the study of evolution and host adaptation of H1N1 influenza A viruses. The notion that the avian HA is associated with preferential specificity for receptors with Siaα2,3Gal glycosidic linkage over those with Siaα2,6Gal linkage is not all consistent with the available data on H1N1 viruses. By x-ray crystallography, the HA structure of an avian H1N1 influenza A virus, as well as its complexes with the receptor analogs, was determined. The structures revealed no preferential binding of avian receptor analogs over that of the human analog, suggesting that the HA/receptor binding might not be as stringent as is commonly believed in determining the host receptor preference for some subtypes of influenza viruses, such as the H1N1 viruses. The structure also showed difference in glycosylation despite the preservation of related sequences, which may partly contribute to the difference between structures of human and avian origin. © 2009 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationVirology, 2009, v. 392 n. 1, p. 73-81 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.virol.2009.06.028
 
dc.identifier.citeulike5274256
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.virol.2009.06.028
 
dc.identifier.epage81
 
dc.identifier.isiWOS:000269783500008
Funding AgencyGrant Number
National Science Foundation of China30870479
111 Project of ChinaB06016
Providence Foundation Limited
Research Fund for Infections Diseases of Hong Kong SAR
Li Ka Shing Foundation
Funding Information:

Discussions with Drs. Yi Guan and Honglin Chen helped greatly on the research, which are gratefully acknowledged. The authors thank the help from Dr. Vukica Srajer and others at the BioCARS of the Advance Photo Sources for data collection and processing. The work is supported by the National Science Foundation of China (Grant No. 30870479), the 111 Project of China No. B06016), the Providence Foundation Limited in memory of the late Dr. Lui Hac Minh, the Research Fund for Infections Diseases of Hong Kong SAR, and the Li Ka Shing Foundation.

 
dc.identifier.issn0042-6822
2012 Impact Factor: 3.367
2012 SCImago Journal Rankings: 1.428
 
dc.identifier.issue1
 
dc.identifier.pmid19628241
 
dc.identifier.scopuseid_2-s2.0-69249221242
 
dc.identifier.spage73
 
dc.identifier.urihttp://hdl.handle.net/10722/157556
 
dc.identifier.volume392
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
 
dc.publisher.placeUnited States
 
dc.relation.ispartofVirology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAmino Acid Sequence
 
dc.subject.meshAnimals
 
dc.subject.meshBase Sequence
 
dc.subject.meshBinding Sites
 
dc.subject.meshBirds - Virology
 
dc.subject.meshCarbohydrate Sequence
 
dc.subject.meshCrystallography, X-Ray
 
dc.subject.meshDna Primers - Genetics
 
dc.subject.meshGlycosylation
 
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus - Chemistry - Genetics
 
dc.subject.meshHumans
 
dc.subject.meshInfluenza A Virus, H1n1 Subtype - Chemistry - Genetics
 
dc.subject.meshMammals
 
dc.subject.meshModels, Molecular
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshMolecular Structure
 
dc.subject.meshProtein Structure, Quaternary
 
dc.subject.meshReceptors, Virus - Chemistry
 
dc.subject.meshSequence Homology, Amino Acid
 
dc.subject.meshSpecies Specificity
 
dc.subject.meshStatic Electricity
 
dc.titleThe hemagglutinin structure of an avian H1N1 influenza A virus
 
dc.typeArticle
 
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<contributor.author>Zhang, R</contributor.author>
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Author Affiliations
  1. Research Centre of Infection and Immunology
  2. Xiamen University
  3. Shantou University
  4. Medical College