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Article: Molecular epidemiological study of HIV-1 CRF01-ae transmission in Hong Kong

TitleMolecular epidemiological study of HIV-1 CRF01-ae transmission in Hong Kong
Authors
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
Citation
Journal Of Acquired Immune Deficiency Syndromes, 2009, v. 51 n. 5, p. 530-535 How to Cite?
AbstractOBJECTIVES:: The objective of this study was to investigate the transmission history of the HIV-1 CRF01-AE epidemics in Hong Kong between 1994 and 2007. METHODS:: A total of 465 HIV-1 CRF01-AE pol sequences were derived from an in-house or a commercial HIV-1 genotyping system. Phylogenies of CRF01-AE sequences were analyzed by the Bayesian coalescent method. RESULTS:: CRF01-AE patient population included 363 males (78.1%) and 102 females (21.9%), whereas 65% (314 of 465) were local Chinese. Major transmission routes were heterosexual contact (63%), followed by intravenous drug use (IDU) (19%) and men having sex with men (MSM) (17%). From phylogenetic analysis, local CRF01-AE strains were from multiple origins with 3 separate transmission clusters identified. Cluster 1 consisted mainly of Chinese male IDUs and heterosexuals. Clusters 2 and 3 included mainly local Chinese MSM and non-Chinese Asian IDUs, respectively. Chinese reference isolates available from China (Fujian, Guangxi, or Liaoning) were clonally related to our transmission clusters, demonstrating the epidemiological linkage of CRF01-AE infections between Hong Kong and China. The 3 individual local transmission clusters were estimated to have initiated since late 1980s and late 1990s, causing subsequent epidemics in the early 2000s. CONCLUSIONS:: This is the first comprehensive molecular epidemiological study of HIV-1 CRF01-AE in Hong Kong. It revealed that MSM contact is becoming a major route of local CRF01-AE transmission in Hong Kong. Epidemiological linkage of CRF01-AE between Hong Kong and China observed in this study indicates the importance of regular molecular epidemiological surveillance for the HIV-1 epidemic in our region. Copyright © 2009 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/157554
ISSN
2015 Impact Factor: 3.806
2015 SCImago Journal Rankings: 2.434
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, JHKen_US
dc.contributor.authorWong, KHen_US
dc.contributor.authorLi, Pen_US
dc.contributor.authorChan, KCen_US
dc.contributor.authorLee, MPen_US
dc.contributor.authorLam, HYen_US
dc.contributor.authorCheng, VCCen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorYam, WCen_US
dc.date.accessioned2012-08-08T08:51:12Z-
dc.date.available2012-08-08T08:51:12Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Acquired Immune Deficiency Syndromes, 2009, v. 51 n. 5, p. 530-535en_US
dc.identifier.issn1525-4135en_US
dc.identifier.urihttp://hdl.handle.net/10722/157554-
dc.description.abstractOBJECTIVES:: The objective of this study was to investigate the transmission history of the HIV-1 CRF01-AE epidemics in Hong Kong between 1994 and 2007. METHODS:: A total of 465 HIV-1 CRF01-AE pol sequences were derived from an in-house or a commercial HIV-1 genotyping system. Phylogenies of CRF01-AE sequences were analyzed by the Bayesian coalescent method. RESULTS:: CRF01-AE patient population included 363 males (78.1%) and 102 females (21.9%), whereas 65% (314 of 465) were local Chinese. Major transmission routes were heterosexual contact (63%), followed by intravenous drug use (IDU) (19%) and men having sex with men (MSM) (17%). From phylogenetic analysis, local CRF01-AE strains were from multiple origins with 3 separate transmission clusters identified. Cluster 1 consisted mainly of Chinese male IDUs and heterosexuals. Clusters 2 and 3 included mainly local Chinese MSM and non-Chinese Asian IDUs, respectively. Chinese reference isolates available from China (Fujian, Guangxi, or Liaoning) were clonally related to our transmission clusters, demonstrating the epidemiological linkage of CRF01-AE infections between Hong Kong and China. The 3 individual local transmission clusters were estimated to have initiated since late 1980s and late 1990s, causing subsequent epidemics in the early 2000s. CONCLUSIONS:: This is the first comprehensive molecular epidemiological study of HIV-1 CRF01-AE in Hong Kong. It revealed that MSM contact is becoming a major route of local CRF01-AE transmission in Hong Kong. Epidemiological linkage of CRF01-AE between Hong Kong and China observed in this study indicates the importance of regular molecular epidemiological surveillance for the HIV-1 epidemic in our region. Copyright © 2009 by Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.comen_US
dc.relation.ispartofJournal of Acquired Immune Deficiency Syndromesen_US
dc.rightsJournal of Acquired Immune Deficiency Syndromes. Copyright © Lippincott Williams & Wilkins.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Polen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHiv Infections - Complications - Epidemiology - Transmission - Virologyen_US
dc.subject.meshHiv-1 - Classification - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfectious Disease Transmission, Verticalen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Epidemiologyen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications, Infectious - Epidemiology - Virologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshYoung Adulten_US
dc.titleMolecular epidemiological study of HIV-1 CRF01-ae transmission in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.identifier.authorityYam, WC=rp00313en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/QAI.0b013e3181aac516en_US
dc.identifier.pmid19521252-
dc.identifier.scopuseid_2-s2.0-68449094359en_US
dc.identifier.hkuros157554-
dc.identifier.hkuros179898-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68449094359&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume51en_US
dc.identifier.issue5en_US
dc.identifier.spage530en_US
dc.identifier.epage535en_US
dc.identifier.isiWOS:000268346600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, JHK=35085819900en_US
dc.identifier.scopusauthoridWong, KH=7404758411en_US
dc.identifier.scopusauthoridLi, P=36068280500en_US
dc.identifier.scopusauthoridChan, KC=35097079800en_US
dc.identifier.scopusauthoridLee, MP=7409121315en_US
dc.identifier.scopusauthoridLam, HY=35097472400en_US
dc.identifier.scopusauthoridCheng, VCC=23670479400en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridYam, WC=7004281720en_US

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