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Article: Gene flow and competitive exclusion of avian influenza A virus in natural reservoir hosts

TitleGene flow and competitive exclusion of avian influenza A virus in natural reservoir hosts
Authors
KeywordsCompetition
Ecology
Evolution
Influenza A virus
Population dynamics
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2009, v. 390 n. 2, p. 289-297 How to Cite?
AbstractGeographical separation of host species has shaped the avian influenza A virus gene pool into independently evolving Eurasian and American lineages, although phylogenetic evidence for gene flow and reassortment indicates that these lineages also mix on occasion. While the evolutionary dynamics of the avian influenza gene pool have been described, the consequences of gene flow on virus evolution and population structure in this system have not been investigated. Here we show that viral gene flow from Eurasia has led to the replacement of endemic avian influenza viruses in North America, likely through competition for susceptible hosts. This competition is characterized by changes in rates of nucleotide substitution and selection pressures. However, the discontinuous distribution of susceptible hosts may produce long periods of co-circulation of competing virus strains before lineage extinction occurs. These results also suggest that viral competition for host resources may be an important mechanism in disease emergence. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157550
ISSN
2015 Impact Factor: 3.2
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID
Funding AgencyGrant Number
University Grants CommitteeAoE/M-12/06
National Institutes of HealthHHSN266200700005C
Funding Information:

This work was supported by the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06) of the Hong Kong SAR Government, the National Institutes of Health (NIAID contract HHSN266200700005C), and the Li Ka Shing Foundation. GJDS is supported by a career development award under NIAID contract HHSN266200700005C.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorBahl, Jen_US
dc.contributor.authorVijaykrishna, Den_US
dc.contributor.authorHolmes, ECen_US
dc.contributor.authorSmith, GJDen_US
dc.contributor.authorGuan, Yen_US
dc.date.accessioned2012-08-08T08:51:10Z-
dc.date.available2012-08-08T08:51:10Z-
dc.date.issued2009en_US
dc.identifier.citationVirology, 2009, v. 390 n. 2, p. 289-297en_US
dc.identifier.issn0042-6822en_US
dc.identifier.urihttp://hdl.handle.net/10722/157550-
dc.description.abstractGeographical separation of host species has shaped the avian influenza A virus gene pool into independently evolving Eurasian and American lineages, although phylogenetic evidence for gene flow and reassortment indicates that these lineages also mix on occasion. While the evolutionary dynamics of the avian influenza gene pool have been described, the consequences of gene flow on virus evolution and population structure in this system have not been investigated. Here we show that viral gene flow from Eurasia has led to the replacement of endemic avian influenza viruses in North America, likely through competition for susceptible hosts. This competition is characterized by changes in rates of nucleotide substitution and selection pressures. However, the discontinuous distribution of susceptible hosts may produce long periods of co-circulation of competing virus strains before lineage extinction occurs. These results also suggest that viral competition for host resources may be an important mechanism in disease emergence. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_US
dc.relation.ispartofVirologyen_US
dc.subjectCompetition-
dc.subjectEcology-
dc.subjectEvolution-
dc.subjectInfluenza A virus-
dc.subjectPopulation dynamics-
dc.subject.meshAnimalsen_US
dc.subject.meshAsiaen_US
dc.subject.meshBirdsen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshDisease Reservoirs - Virologyen_US
dc.subject.meshEuropeen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshGene Flowen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus - Geneticsen_US
dc.subject.meshInfluenza In Birds - Virologyen_US
dc.subject.meshMolecular Epidemiologyen_US
dc.subject.meshNorth Americaen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshRna, Viral - Geneticsen_US
dc.subject.meshSequence Homologyen_US
dc.titleGene flow and competitive exclusion of avian influenza A virus in natural reservoir hostsen_US
dc.typeArticleen_US
dc.identifier.emailSmith, GJD:gjsmith@hkucc.hku.hken_US
dc.identifier.emailGuan, Y:yguan@hkucc.hku.hken_US
dc.identifier.authoritySmith, GJD=rp00444en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.virol.2009.05.002en_US
dc.identifier.pmid19501380-
dc.identifier.scopuseid_2-s2.0-67649866123en_US
dc.identifier.hkuros157951-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649866123&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume390en_US
dc.identifier.issue2en_US
dc.identifier.spage289en_US
dc.identifier.epage297en_US
dc.identifier.isiWOS:000268218500016-
dc.publisher.placeUnited Statesen_US
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridBahl, J=35308668200en_US
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_US
dc.identifier.scopusauthoridHolmes, EC=35433598300en_US
dc.identifier.scopusauthoridSmith, GJD=8344015800en_US
dc.identifier.scopusauthoridGuan, Y=7202924055en_US
dc.identifier.citeulike4828465-

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