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Article: Avian influenza A (H5N1) infection in a patient in China, 2006.

TitleAvian influenza A (H5N1) infection in a patient in China, 2006.
Authors
Issue Date2007
Citation
Influenza And Other Respiratory Viruses, 2007, v. 1 n. 5-6, p. 207-213 How to Cite?
AbstractBACKGROUND: Highly pathogenic avian influenza H5N1 virus has caused increasing human infection in Eurasia since 2004. So far, H5N1 human infection has been associated with over 50% mortality that is partly because of delay of diagnosis and treatment. OBJECTIVES AND METHODS: Here, we report that an H5N1 influenza virus infected a 31-year-old patient in Shenzhen in June 2006. To identify the possible source of the infection, the human isolate and other H5N1 influenza viruses obtained from poultry and wild birds in southern China during the same period of time were characterized. RESULTS: Genetic and antigenic analyses revealed that the human H5N1 influenza virus, Shenzhen/406H/06, is of purely avian origin and is most closely related to viruses detected in poultry and wild birds in Hong Kong in early 2006. CONCLUSIONS: The findings of the present study suggest that the continued endemicity of H5N1 influenza virus in the poultry in southern China increases the chance for introduction of the virus to humans. This highlights the importance of continued surveillance of poultry and wild birds for determining the source for human H5N1 infection.
Persistent Identifierhttp://hdl.handle.net/10722/157548
ISSN
2014 Impact Factor: 2.201
2014 SCImago Journal Rankings: 0.976
ISI Accession Number ID
Funding AgencyGrant Number
Shenzhen Health Bureau and Guangdong Provincial Government
Li Ka Shing Foundation
National Institutes of Health under NIAIDHHSN266200700005C
Funding Information:

This work was supported by the Shenzhen Health Bureau and Guangdong Provincial Government and the Li Ka Shing Foundation. GJDS is supported by a career development award from the National Institutes of Health under NIAID contract HHSN266200700005C.

 

DC FieldValueLanguage
dc.contributor.authorChen, Xen_US
dc.contributor.authorSmith, GJen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorQiu, Cen_US
dc.contributor.authorWu, WLen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorLu, Pen_US
dc.contributor.authorDuan, Len_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorYuan, Jen_US
dc.contributor.authorYang, Gen_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorCheng, Jen_US
dc.contributor.authorJiang, Hen_US
dc.contributor.authorPeiris, JSen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorZhong, Nen_US
dc.contributor.authorGuan, Yen_US
dc.date.accessioned2012-08-08T08:51:10Z-
dc.date.available2012-08-08T08:51:10Z-
dc.date.issued2007en_US
dc.identifier.citationInfluenza And Other Respiratory Viruses, 2007, v. 1 n. 5-6, p. 207-213en_US
dc.identifier.issn1750-2659en_US
dc.identifier.urihttp://hdl.handle.net/10722/157548-
dc.description.abstractBACKGROUND: Highly pathogenic avian influenza H5N1 virus has caused increasing human infection in Eurasia since 2004. So far, H5N1 human infection has been associated with over 50% mortality that is partly because of delay of diagnosis and treatment. OBJECTIVES AND METHODS: Here, we report that an H5N1 influenza virus infected a 31-year-old patient in Shenzhen in June 2006. To identify the possible source of the infection, the human isolate and other H5N1 influenza viruses obtained from poultry and wild birds in southern China during the same period of time were characterized. RESULTS: Genetic and antigenic analyses revealed that the human H5N1 influenza virus, Shenzhen/406H/06, is of purely avian origin and is most closely related to viruses detected in poultry and wild birds in Hong Kong in early 2006. CONCLUSIONS: The findings of the present study suggest that the continued endemicity of H5N1 influenza virus in the poultry in southern China increases the chance for introduction of the virus to humans. This highlights the importance of continued surveillance of poultry and wild birds for determining the source for human H5N1 infection.en_US
dc.languageengen_US
dc.relation.ispartofInfluenza and other respiratory virusesen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Viral - Analysisen_US
dc.subject.meshBirds - Virologyen_US
dc.subject.meshChinaen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Genetics - Immunology - Isolation & Purificationen_US
dc.subject.meshInfluenza, Human - Diagnosis - Virologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPoultry - Virologyen_US
dc.subject.meshRna, Viral - Geneticsen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.titleAvian influenza A (H5N1) infection in a patient in China, 2006.en_US
dc.typeArticleen_US
dc.identifier.emailSmith, GJ:gjsmith@hkucc.hku.hken_US
dc.identifier.emailPeiris, JS:malik@hkucc.hku.hken_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.emailGuan, Y:yguan@hkucc.hku.hken_US
dc.identifier.authoritySmith, GJ=rp00444en_US
dc.identifier.authorityPeiris, JS=rp00410en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1750-2659.2007.00032.x-
dc.identifier.pmid19453428en_US
dc.identifier.scopuseid_2-s2.0-66449136070en_US
dc.identifier.hkuros146112-
dc.identifier.volume1en_US
dc.identifier.issue5-6en_US
dc.identifier.spage207en_US
dc.identifier.epage213en_US
dc.identifier.isiWOS:000207070000006-
dc.identifier.scopusauthoridChen, X=8710357400en_US
dc.identifier.scopusauthoridSmith, GJ=8344015800en_US
dc.identifier.scopusauthoridZhou, B=7401906727en_US
dc.identifier.scopusauthoridQiu, C=35277368000en_US
dc.identifier.scopusauthoridWu, WL=16835478800en_US
dc.identifier.scopusauthoridLi, Y=8934248500en_US
dc.identifier.scopusauthoridLu, P=55041420800en_US
dc.identifier.scopusauthoridDuan, L=7201932765en_US
dc.identifier.scopusauthoridLiu, S=7409464778en_US
dc.identifier.scopusauthoridYuan, J=35277840900en_US
dc.identifier.scopusauthoridYang, G=7405754750en_US
dc.identifier.scopusauthoridWang, H=13805533100en_US
dc.identifier.scopusauthoridCheng, J=7405940946en_US
dc.identifier.scopusauthoridJiang, H=36698011400en_US
dc.identifier.scopusauthoridPeiris, JS=7005486823en_US
dc.identifier.scopusauthoridChen, H=8898573000en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridZhong, N=7102137996en_US
dc.identifier.scopusauthoridGuan, Y=7202924055en_US

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