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Article: Avian influenza A (H5N1) infection in a patient in China, 2006.
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TitleAvian influenza A (H5N1) infection in a patient in China, 2006.
 
AuthorsChen, X1
Smith, GJ1
Zhou, B1
Qiu, C1
Wu, WL1
Li, Y1
Lu, P1
Duan, L1
Liu, S1
Yuan, J1
Yang, G1
Wang, H1
Cheng, J1
Jiang, H1
Peiris, JS1
Chen, H1
Yuen, KY1
Zhong, N1
Guan, Y1
 
Issue Date2007
 
CitationInfluenza And Other Respiratory Viruses, 2007, v. 1 n. 5-6, p. 207-213 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1750-2659.2007.00032.x
 
AbstractBACKGROUND: Highly pathogenic avian influenza H5N1 virus has caused increasing human infection in Eurasia since 2004. So far, H5N1 human infection has been associated with over 50% mortality that is partly because of delay of diagnosis and treatment. OBJECTIVES AND METHODS: Here, we report that an H5N1 influenza virus infected a 31-year-old patient in Shenzhen in June 2006. To identify the possible source of the infection, the human isolate and other H5N1 influenza viruses obtained from poultry and wild birds in southern China during the same period of time were characterized. RESULTS: Genetic and antigenic analyses revealed that the human H5N1 influenza virus, Shenzhen/406H/06, is of purely avian origin and is most closely related to viruses detected in poultry and wild birds in Hong Kong in early 2006. CONCLUSIONS: The findings of the present study suggest that the continued endemicity of H5N1 influenza virus in the poultry in southern China increases the chance for introduction of the virus to humans. This highlights the importance of continued surveillance of poultry and wild birds for determining the source for human H5N1 infection.
 
ISSN1750-2659
2013 SCImago Journal Rankings: 1.115
 
DOIhttp://dx.doi.org/10.1111/j.1750-2659.2007.00032.x
 
ISI Accession Number IDWOS:000207070000006
Funding AgencyGrant Number
Shenzhen Health Bureau and Guangdong Provincial Government
Li Ka Shing Foundation
National Institutes of Health under NIAIDHHSN266200700005C
Funding Information:

This work was supported by the Shenzhen Health Bureau and Guangdong Provincial Government and the Li Ka Shing Foundation. GJDS is supported by a career development award from the National Institutes of Health under NIAID contract HHSN266200700005C.

 
DC FieldValue
dc.contributor.authorChen, X
 
dc.contributor.authorSmith, GJ
 
dc.contributor.authorZhou, B
 
dc.contributor.authorQiu, C
 
dc.contributor.authorWu, WL
 
dc.contributor.authorLi, Y
 
dc.contributor.authorLu, P
 
dc.contributor.authorDuan, L
 
dc.contributor.authorLiu, S
 
dc.contributor.authorYuan, J
 
dc.contributor.authorYang, G
 
dc.contributor.authorWang, H
 
dc.contributor.authorCheng, J
 
dc.contributor.authorJiang, H
 
dc.contributor.authorPeiris, JS
 
dc.contributor.authorChen, H
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorZhong, N
 
dc.contributor.authorGuan, Y
 
dc.date.accessioned2012-08-08T08:51:10Z
 
dc.date.available2012-08-08T08:51:10Z
 
dc.date.issued2007
 
dc.description.abstractBACKGROUND: Highly pathogenic avian influenza H5N1 virus has caused increasing human infection in Eurasia since 2004. So far, H5N1 human infection has been associated with over 50% mortality that is partly because of delay of diagnosis and treatment. OBJECTIVES AND METHODS: Here, we report that an H5N1 influenza virus infected a 31-year-old patient in Shenzhen in June 2006. To identify the possible source of the infection, the human isolate and other H5N1 influenza viruses obtained from poultry and wild birds in southern China during the same period of time were characterized. RESULTS: Genetic and antigenic analyses revealed that the human H5N1 influenza virus, Shenzhen/406H/06, is of purely avian origin and is most closely related to viruses detected in poultry and wild birds in Hong Kong in early 2006. CONCLUSIONS: The findings of the present study suggest that the continued endemicity of H5N1 influenza virus in the poultry in southern China increases the chance for introduction of the virus to humans. This highlights the importance of continued surveillance of poultry and wild birds for determining the source for human H5N1 infection.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInfluenza And Other Respiratory Viruses, 2007, v. 1 n. 5-6, p. 207-213 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1750-2659.2007.00032.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1750-2659.2007.00032.x
 
dc.identifier.epage213
 
dc.identifier.hkuros146112
 
dc.identifier.isiWOS:000207070000006
Funding AgencyGrant Number
Shenzhen Health Bureau and Guangdong Provincial Government
Li Ka Shing Foundation
National Institutes of Health under NIAIDHHSN266200700005C
Funding Information:

This work was supported by the Shenzhen Health Bureau and Guangdong Provincial Government and the Li Ka Shing Foundation. GJDS is supported by a career development award from the National Institutes of Health under NIAID contract HHSN266200700005C.

 
dc.identifier.issn1750-2659
2013 SCImago Journal Rankings: 1.115
 
dc.identifier.issue5-6
 
dc.identifier.pmid19453428
 
dc.identifier.scopuseid_2-s2.0-66449136070
 
dc.identifier.spage207
 
dc.identifier.urihttp://hdl.handle.net/10722/157548
 
dc.identifier.volume1
 
dc.languageeng
 
dc.relation.ispartofInfluenza and other respiratory viruses
 
dc.rightsThe definitive version is available at www.blackwell-synergy.com
 
dc.subject.meshAdult
 
dc.subject.meshAnimals
 
dc.subject.meshAntigens, Viral - Analysis
 
dc.subject.meshBirds - Virology
 
dc.subject.meshChina
 
dc.subject.meshHumans
 
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Genetics - Immunology - Isolation & Purification
 
dc.subject.meshInfluenza, Human - Diagnosis - Virology
 
dc.subject.meshMale
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshPoultry - Virology
 
dc.subject.meshRna, Viral - Genetics
 
dc.subject.meshSequence Analysis, Dna
 
dc.titleAvian influenza A (H5N1) infection in a patient in China, 2006.
 
dc.typeArticle
 
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<contributor.author>Smith, GJ</contributor.author>
<contributor.author>Zhou, B</contributor.author>
<contributor.author>Qiu, C</contributor.author>
<contributor.author>Wu, WL</contributor.author>
<contributor.author>Li, Y</contributor.author>
<contributor.author>Lu, P</contributor.author>
<contributor.author>Duan, L</contributor.author>
<contributor.author>Liu, S</contributor.author>
<contributor.author>Yuan, J</contributor.author>
<contributor.author>Yang, G</contributor.author>
<contributor.author>Wang, H</contributor.author>
<contributor.author>Cheng, J</contributor.author>
<contributor.author>Jiang, H</contributor.author>
<contributor.author>Peiris, JS</contributor.author>
<contributor.author>Chen, H</contributor.author>
<contributor.author>Yuen, KY</contributor.author>
<contributor.author>Zhong, N</contributor.author>
<contributor.author>Guan, Y</contributor.author>
<date.accessioned>2012-08-08T08:51:10Z</date.accessioned>
<date.available>2012-08-08T08:51:10Z</date.available>
<date.issued>2007</date.issued>
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<identifier.uri>http://hdl.handle.net/10722/157548</identifier.uri>
<description.abstract>BACKGROUND: Highly pathogenic avian influenza H5N1 virus has caused increasing human infection in Eurasia since 2004. So far, H5N1 human infection has been associated with over 50% mortality that is partly because of delay of diagnosis and treatment. OBJECTIVES AND METHODS: Here, we report that an H5N1 influenza virus infected a 31-year-old patient in Shenzhen in June 2006. To identify the possible source of the infection, the human isolate and other H5N1 influenza viruses obtained from poultry and wild birds in southern China during the same period of time were characterized. RESULTS: Genetic and antigenic analyses revealed that the human H5N1 influenza virus, Shenzhen/406H/06, is of purely avian origin and is most closely related to viruses detected in poultry and wild birds in Hong Kong in early 2006. CONCLUSIONS: The findings of the present study suggest that the continued endemicity of H5N1 influenza virus in the poultry in southern China increases the chance for introduction of the virus to humans. This highlights the importance of continued surveillance of poultry and wild birds for determining the source for human H5N1 infection.</description.abstract>
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<subject.mesh>China</subject.mesh>
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<subject.mesh>Male</subject.mesh>
<subject.mesh>Molecular Sequence Data</subject.mesh>
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Author Affiliations
  1. Shenzhen Donghu Hospital