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Article: Prevalence of avian influenza virus receptor in human respiratory tract

TitlePrevalence of avian influenza virus receptor in human respiratory tract
Authors
KeywordsH5N1
Influenza A virus
SAα2,3Gal linkage
SAα2,6Gal linkage
Sialic acid receptors
Issue Date2008
Citation
Progress In Biochemistry And Biophysics, 2008, v. 35 n. 12, p. 1387-1393 How to Cite?
AbstractSAα2,6 and SAα2,3 linked sialic acid molecules on epithelial cell membrane served as receptors for influenza virus, which are specifically recognized by human and avian influenza viruses, respectively. The distribution of these two species of sialic acids in human respiratory tract from different anatomical sites and different age groups was investigated. The results showed that SAα2,3Gal species was prevalent in respiratory bronchiole and lung alveolar epithelium, but was infrequent in trachea, bronchus and bronchiole. On the contrary, the SAα2,6Gal species was more common in the trachea and bronchus and to a lesser degree in the alveolar epithelium. When compared the expression levels of SAα2,6Gal and α2,3Gal in the respiratory tract among different age groups, no significant difference was found. In the ex vivo H5N1 virus infection study, alveolus epithelium were found to be more susceptible to avian influenza than trachea and bronchus epithelial cells. These results suggest that the human respiratory tract, to some extent, is permissive for avian influenza viruses. The currently-observed limited human to human transmission of H5N1 virus may be associated with the different abundance of SAα2,3Gal linkages in human upper respiratory tract among individuals.
Persistent Identifierhttp://hdl.handle.net/10722/157543
ISSN
2015 Impact Factor: 0.224
2015 SCImago Journal Rankings: 0.138
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZFen_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorLuo, DZen_HK
dc.contributor.authorFeng, ZBen_HK
dc.contributor.authorWei, MYen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorChen, HLen_HK
dc.contributor.authorZhang, JXen_HK
dc.date.accessioned2012-08-08T08:51:07Z-
dc.date.available2012-08-08T08:51:07Z-
dc.date.issued2008en_HK
dc.identifier.citationProgress In Biochemistry And Biophysics, 2008, v. 35 n. 12, p. 1387-1393en_HK
dc.identifier.issn1000-3282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157543-
dc.description.abstractSAα2,6 and SAα2,3 linked sialic acid molecules on epithelial cell membrane served as receptors for influenza virus, which are specifically recognized by human and avian influenza viruses, respectively. The distribution of these two species of sialic acids in human respiratory tract from different anatomical sites and different age groups was investigated. The results showed that SAα2,3Gal species was prevalent in respiratory bronchiole and lung alveolar epithelium, but was infrequent in trachea, bronchus and bronchiole. On the contrary, the SAα2,6Gal species was more common in the trachea and bronchus and to a lesser degree in the alveolar epithelium. When compared the expression levels of SAα2,6Gal and α2,3Gal in the respiratory tract among different age groups, no significant difference was found. In the ex vivo H5N1 virus infection study, alveolus epithelium were found to be more susceptible to avian influenza than trachea and bronchus epithelial cells. These results suggest that the human respiratory tract, to some extent, is permissive for avian influenza viruses. The currently-observed limited human to human transmission of H5N1 virus may be associated with the different abundance of SAα2,3Gal linkages in human upper respiratory tract among individuals.en_HK
dc.languageengen_US
dc.relation.ispartofProgress in Biochemistry and Biophysicsen_HK
dc.subjectH5N1en_HK
dc.subjectInfluenza A virusen_HK
dc.subjectSAα2,3Gal linkageen_HK
dc.subjectSAα2,6Gal linkageen_HK
dc.subjectSialic acid receptorsen_HK
dc.titlePrevalence of avian influenza virus receptor in human respiratory tracten_HK
dc.typeArticleen_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailChen, HL: hlchen@hku.hken_HK
dc.identifier.emailZhang, JX: zhangajx@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityChen, HL=rp00383en_HK
dc.identifier.authorityZhang, JX=rp00413en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-64749098330en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64749098330&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1387en_HK
dc.identifier.epage1393en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridZhang, ZF=25930204600en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridLuo, DZ=7202658140en_HK
dc.identifier.scopusauthoridFeng, ZB=8429407100en_HK
dc.identifier.scopusauthoridWei, MY=35207510800en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridChen, HL=26643315400en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK

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