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Article: Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus

TitleLong-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus
Authors
Issue Date2006
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2006, v. 1 n. 1 How to Cite?
AbstractMost of the individuals infected with SARS coronavirus (SARS-CoV) spontaneously recovered without clinical intervention. However, the immunological correlates associated with patients' recovery are currently unknown. In this report, we have sequentially monitored 30 recovered patients over a two-year period to characterize temporal changes in SARS-CoV-specific antibody responses as well as cytotoxic T cell (CTL) responses. We have found persistence of robust antibody and CTL responses in all of the study subjects throughout the study period, with a moderate decline one year after the onset of symptoms. We have also identified two potential major CTL epitopes in N proteins based on ELISPOT analysis of pooled peptides. However, despite the potent immune responses and clinical recovery, peripheral lymphocyte counts in the recovered patients have not yet been restored to normal levels. In summary, our study has, for the first time, characterized the temporal and dynamic changes of humoral and CTL responses in the natural history of SARS-recovered individuals, and strongly supports the notion that high and sustainable levels of immune responses correlate strongly with the disease outcome. Our findings have direct implications for future design and development of effective therapeutic agents and vaccines against SARS-CoV infection. © 2006 Li et al.
Persistent Identifierhttp://hdl.handle.net/10722/157531
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
Funding AgencyGrant Number
Chinese Ministry of Science and Technology
National Institute of Health (NIH)U19 AI51915-02
European CommissionSP22-CT2004-511063
Funding Information:

This work was supported by the Chinese Ministry of Science and Technology, and partly by National Institute of Health (NIH) CIPRA-SARS Project (NIH U19 AI51915-02) and the European Commission grant EPISARS (SP22-CT2004-511063). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorXie, Jen_US
dc.contributor.authorHe, Yen_US
dc.contributor.authorFan, Hen_US
dc.contributor.authorBaril, Len_US
dc.contributor.authorQiu, Zen_US
dc.contributor.authorHan, Yen_US
dc.contributor.authorXu, Wen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorYou, Hen_US
dc.contributor.authorZuo, Yen_US
dc.contributor.authorFang, Qen_US
dc.contributor.authorYu, Jen_US
dc.contributor.authorChen, Zen_US
dc.contributor.authorZhang, Len_US
dc.date.accessioned2012-08-08T08:51:00Z-
dc.date.available2012-08-08T08:51:00Z-
dc.date.issued2006en_US
dc.identifier.citationPlos One, 2006, v. 1 n. 1en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/157531-
dc.description.abstractMost of the individuals infected with SARS coronavirus (SARS-CoV) spontaneously recovered without clinical intervention. However, the immunological correlates associated with patients' recovery are currently unknown. In this report, we have sequentially monitored 30 recovered patients over a two-year period to characterize temporal changes in SARS-CoV-specific antibody responses as well as cytotoxic T cell (CTL) responses. We have found persistence of robust antibody and CTL responses in all of the study subjects throughout the study period, with a moderate decline one year after the onset of symptoms. We have also identified two potential major CTL epitopes in N proteins based on ELISPOT analysis of pooled peptides. However, despite the potent immune responses and clinical recovery, peripheral lymphocyte counts in the recovered patients have not yet been restored to normal levels. In summary, our study has, for the first time, characterized the temporal and dynamic changes of humoral and CTL responses in the natural history of SARS-recovered individuals, and strongly supports the notion that high and sustainable levels of immune responses correlate strongly with the disease outcome. Our findings have direct implications for future design and development of effective therapeutic agents and vaccines against SARS-CoV infection. © 2006 Li et al.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleLong-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirusen_US
dc.typeArticleen_US
dc.identifier.emailChen, Z:zchenai@hkucc.hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0000024en_US
dc.identifier.pmid17183651-
dc.identifier.scopuseid_2-s2.0-55149099210en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55149099210&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1en_US
dc.identifier.issue1en_US
dc.identifier.isiWOS:000207443600024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=8876653800en_US
dc.identifier.scopusauthoridXie, J=7402994468en_US
dc.identifier.scopusauthoridHe, Y=8742157400en_US
dc.identifier.scopusauthoridFan, H=7402553911en_US
dc.identifier.scopusauthoridBaril, L=7004159068en_US
dc.identifier.scopusauthoridQiu, Z=7202941622en_US
dc.identifier.scopusauthoridHan, Y=22633985900en_US
dc.identifier.scopusauthoridXu, W=7404429675en_US
dc.identifier.scopusauthoridZhang, W=35226069200en_US
dc.identifier.scopusauthoridYou, H=7101663572en_US
dc.identifier.scopusauthoridZuo, Y=25631279600en_US
dc.identifier.scopusauthoridFang, Q=55248545600en_US
dc.identifier.scopusauthoridYu, J=7405525088en_US
dc.identifier.scopusauthoridChen, Z=35271180800en_US
dc.identifier.scopusauthoridZhang, L=8783285300en_US
dc.identifier.citeulike1013398-

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