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Article: Molecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
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TitleMolecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
 
AuthorsHo, PL2
Lai, EL2
Chow, KH2
Chow, LSM1
Yuen, KY2
Yung, RWH1
 
Issue Date2008
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
CitationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 2, p. 135-142 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.12.017
 
AbstractThis territory-wide study evaluated the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in residential care homes for elderly (RCHEs) in Hong Kong. MRSA colonization was assessed by taking swab culture from anterior nares and active skin lesions. Of 487 RCHEs surveyed, 80 MRSA strains were recovered from 1563 residents, giving a prevalence of 5.1%. Twenty-four isolates had SCCmec II, 2 had SCCmec III, 17 had SCCmec IV, 36 had SCCmec V, and 1 had a composite SCCmec type. Pulsed-field gel electrophoresis typing clustered 75 isolates into 7 clones (HKU10 to 50, HKU80, and HKU90). Two predominant types, HKU30 and HKU50, which together account for 75% of all MRSA strains, were found in 13 and 15 of the 18 geographic districts in Hong Kong, respectively. The main features for HKU50 strains were spa t1081/ST45-IV or V, capsular type 8, agrIV, and hla, seg, sei positive. On the other hand, HKU30 strains had spa t002/ST5-II, capsular type 5, agrII, and were hla, seg, sei positive. HKU30 strains were often multidrug resistant (MDR, involving ciprofloxacin, erythromycin, gentamicin, and tetracycline). In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns. © 2008 Elsevier Inc. All rights reserved.
 
ISSN0732-8893
2012 Impact Factor: 2.26
2012 SCImago Journal Rankings: 0.971
 
DOIhttp://dx.doi.org/10.1016/j.diagmicrobio.2007.12.017
 
ISI Accession Number IDWOS:000256489400002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorLai, EL
 
dc.contributor.authorChow, KH
 
dc.contributor.authorChow, LSM
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorYung, RWH
 
dc.date.accessioned2012-08-08T08:50:52Z
 
dc.date.available2012-08-08T08:50:52Z
 
dc.date.issued2008
 
dc.description.abstractThis territory-wide study evaluated the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in residential care homes for elderly (RCHEs) in Hong Kong. MRSA colonization was assessed by taking swab culture from anterior nares and active skin lesions. Of 487 RCHEs surveyed, 80 MRSA strains were recovered from 1563 residents, giving a prevalence of 5.1%. Twenty-four isolates had SCCmec II, 2 had SCCmec III, 17 had SCCmec IV, 36 had SCCmec V, and 1 had a composite SCCmec type. Pulsed-field gel electrophoresis typing clustered 75 isolates into 7 clones (HKU10 to 50, HKU80, and HKU90). Two predominant types, HKU30 and HKU50, which together account for 75% of all MRSA strains, were found in 13 and 15 of the 18 geographic districts in Hong Kong, respectively. The main features for HKU50 strains were spa t1081/ST45-IV or V, capsular type 8, agrIV, and hla, seg, sei positive. On the other hand, HKU30 strains had spa t002/ST5-II, capsular type 5, agrII, and were hla, seg, sei positive. HKU30 strains were often multidrug resistant (MDR, involving ciprofloxacin, erythromycin, gentamicin, and tetracycline). In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns. © 2008 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 2, p. 135-142 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.12.017
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.diagmicrobio.2007.12.017
 
dc.identifier.epage142
 
dc.identifier.isiWOS:000256489400002
 
dc.identifier.issn0732-8893
2012 Impact Factor: 2.26
2012 SCImago Journal Rankings: 0.971
 
dc.identifier.issue2
 
dc.identifier.pmid18272314
 
dc.identifier.scopuseid_2-s2.0-43749099823
 
dc.identifier.spage135
 
dc.identifier.urihttp://hdl.handle.net/10722/157520
 
dc.identifier.volume61
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshAnti-Bacterial Agents - Pharmacology
 
dc.subject.meshCarrier State - Epidemiology - Microbiology
 
dc.subject.meshCluster Analysis
 
dc.subject.meshCross Infection - Epidemiology - Microbiology
 
dc.subject.meshDna Fingerprinting
 
dc.subject.meshDna, Bacterial - Genetics
 
dc.subject.meshDrug Resistance, Multiple, Bacterial
 
dc.subject.meshElectrophoresis, Gel, Pulsed-Field
 
dc.subject.meshGenes, Bacterial
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshMethicillin Resistance - Genetics
 
dc.subject.meshMolecular Epidemiology
 
dc.subject.meshNose - Microbiology
 
dc.subject.meshPrevalence
 
dc.subject.meshStaphylococcal Skin Infections - Epidemiology - Microbiology
 
dc.subject.meshStaphylococcus Aureus - Classification - Drug Effects - Isolation & Purification
 
dc.titleMolecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
 
dc.typeArticle
 
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Author Affiliations
  1. Centre for Health Protection
  2. Centre of Infection