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Article: Molecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong

TitleMolecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kong
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 2, p. 135-142 How to Cite?
Abstract
This territory-wide study evaluated the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in residential care homes for elderly (RCHEs) in Hong Kong. MRSA colonization was assessed by taking swab culture from anterior nares and active skin lesions. Of 487 RCHEs surveyed, 80 MRSA strains were recovered from 1563 residents, giving a prevalence of 5.1%. Twenty-four isolates had SCCmec II, 2 had SCCmec III, 17 had SCCmec IV, 36 had SCCmec V, and 1 had a composite SCCmec type. Pulsed-field gel electrophoresis typing clustered 75 isolates into 7 clones (HKU10 to 50, HKU80, and HKU90). Two predominant types, HKU30 and HKU50, which together account for 75% of all MRSA strains, were found in 13 and 15 of the 18 geographic districts in Hong Kong, respectively. The main features for HKU50 strains were spa t1081/ST45-IV or V, capsular type 8, agrIV, and hla, seg, sei positive. On the other hand, HKU30 strains had spa t002/ST5-II, capsular type 5, agrII, and were hla, seg, sei positive. HKU30 strains were often multidrug resistant (MDR, involving ciprofloxacin, erythromycin, gentamicin, and tetracycline). In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157520
ISSN
2013 Impact Factor: 2.568
2013 SCImago Journal Rankings: 1.275
ISI Accession Number ID
References

 

Author Affiliations
  1. Centre for Health Protection
  2. Centre of Infection
DC FieldValueLanguage
dc.contributor.authorHo, PLen_US
dc.contributor.authorLai, ELen_US
dc.contributor.authorChow, KHen_US
dc.contributor.authorChow, LSMen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorYung, RWHen_US
dc.date.accessioned2012-08-08T08:50:52Z-
dc.date.available2012-08-08T08:50:52Z-
dc.date.issued2008en_US
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2008, v. 61 n. 2, p. 135-142en_US
dc.identifier.issn0732-8893en_US
dc.identifier.urihttp://hdl.handle.net/10722/157520-
dc.description.abstractThis territory-wide study evaluated the molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in residential care homes for elderly (RCHEs) in Hong Kong. MRSA colonization was assessed by taking swab culture from anterior nares and active skin lesions. Of 487 RCHEs surveyed, 80 MRSA strains were recovered from 1563 residents, giving a prevalence of 5.1%. Twenty-four isolates had SCCmec II, 2 had SCCmec III, 17 had SCCmec IV, 36 had SCCmec V, and 1 had a composite SCCmec type. Pulsed-field gel electrophoresis typing clustered 75 isolates into 7 clones (HKU10 to 50, HKU80, and HKU90). Two predominant types, HKU30 and HKU50, which together account for 75% of all MRSA strains, were found in 13 and 15 of the 18 geographic districts in Hong Kong, respectively. The main features for HKU50 strains were spa t1081/ST45-IV or V, capsular type 8, agrIV, and hla, seg, sei positive. On the other hand, HKU30 strains had spa t002/ST5-II, capsular type 5, agrII, and were hla, seg, sei positive. HKU30 strains were often multidrug resistant (MDR, involving ciprofloxacin, erythromycin, gentamicin, and tetracycline). In contrast, HKU50 strains exhibit both multidrug resistance (MDR) (involving ciprofloxacin, erythromycin, and tetracycline, but not gentamicin) and non-MDR patterns. © 2008 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_US
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnti-Bacterial Agents - Pharmacologyen_US
dc.subject.meshCarrier State - Epidemiology - Microbiologyen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshCross Infection - Epidemiology - Microbiologyen_US
dc.subject.meshDna Fingerprintingen_US
dc.subject.meshDna, Bacterial - Geneticsen_US
dc.subject.meshDrug Resistance, Multiple, Bacterialen_US
dc.subject.meshElectrophoresis, Gel, Pulsed-Fielden_US
dc.subject.meshGenes, Bacterialen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMethicillin Resistance - Geneticsen_US
dc.subject.meshMolecular Epidemiologyen_US
dc.subject.meshNose - Microbiologyen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshStaphylococcal Skin Infections - Epidemiology - Microbiologyen_US
dc.subject.meshStaphylococcus Aureus - Classification - Drug Effects - Isolation & Purificationen_US
dc.titleMolecular epidemiology of methicillin-resistant Staphylococcus aureus in residential care homes for the elderly in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.emailChow, KH:khchowb@hku.hken_US
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityChow, KH=rp00370en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.diagmicrobio.2007.12.017en_US
dc.identifier.pmid18272314en_US
dc.identifier.scopuseid_2-s2.0-43749099823en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43749099823&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume61en_US
dc.identifier.issue2en_US
dc.identifier.spage135en_US
dc.identifier.epage142en_US
dc.identifier.isiWOS:000256489400002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridLai, EL=8238477100en_US
dc.identifier.scopusauthoridChow, KH=7202180736en_US
dc.identifier.scopusauthoridChow, LSM=24279360000en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridYung, RWH=7005594277en_US

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