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Article: A novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor

TitleA novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor
Authors
Issue Date2004
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.com
Citation
AIDS, 2004, v. 18 n. 12, p. 1729-1732 How to Cite?
AbstractA Nepalese heterozygous carrier of a CCR5 mutant, designated 118delF, was characterized. There was a 3 basepair deletion at 352-354 in the CCR5 open reading frame, resulting in the deletion of the phe-118 residue located in the third transmembrane domain. The mutant protein has retained antigen specificity near the third extracellular loop (ECL3), but that of ECL2 is markedly reduced. The mutation has also abrogated HIV co-receptor activity. Clinically, the HIV disease had progressed slowly.
Persistent Identifierhttp://hdl.handle.net/10722/157516
ISSN
2015 Impact Factor: 4.407
2015 SCImago Journal Rankings: 3.112
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhao, XYen_US
dc.contributor.authorLee, SSen_US
dc.contributor.authorWong, KHen_US
dc.contributor.authorChan, KCWen_US
dc.contributor.authorHe, ZMen_US
dc.contributor.authorMa, Sen_US
dc.contributor.authorNg, Fen_US
dc.contributor.authorChan, CCSen_US
dc.contributor.authorHo, Ten_US
dc.contributor.authorNg, MHen_US
dc.contributor.authorZheng, Ben_US
dc.date.accessioned2012-08-08T08:50:48Z-
dc.date.available2012-08-08T08:50:48Z-
dc.date.issued2004en_US
dc.identifier.citationAIDS, 2004, v. 18 n. 12, p. 1729-1732en_US
dc.identifier.issn0269-9370en_US
dc.identifier.urihttp://hdl.handle.net/10722/157516-
dc.description.abstractA Nepalese heterozygous carrier of a CCR5 mutant, designated 118delF, was characterized. There was a 3 basepair deletion at 352-354 in the CCR5 open reading frame, resulting in the deletion of the phe-118 residue located in the third transmembrane domain. The mutant protein has retained antigen specificity near the third extracellular loop (ECL3), but that of ECL2 is markedly reduced. The mutation has also abrogated HIV co-receptor activity. Clinically, the HIV disease had progressed slowly.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.comen_US
dc.relation.ispartofAIDSen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshHiv Infections - Genetics - Immunologyen_US
dc.subject.meshHiv-1 - Genetics - Immunologyen_US
dc.subject.meshHeterozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshMutation - Genetics - Immunologyen_US
dc.subject.meshRna, Messenger - Analysisen_US
dc.subject.meshRna, Viral - Analysisen_US
dc.subject.meshReceptors, Ccr5 - Genetics - Immunologyen_US
dc.subject.meshReceptors, Chemokine - Genetics - Immunologyen_US
dc.subject.meshReceptors, Hiv - Genetics - Immunologyen_US
dc.subject.meshSequence Deletionen_US
dc.titleA novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptoren_US
dc.typeArticleen_US
dc.identifier.emailChan, KCW: kchan10@HKUCC.hku.hken_US
dc.identifier.emailNg, F: fng@HKUCC-COM.hku.hk-
dc.identifier.emailChan, CS: cschan@hkucc.hku.hk-
dc.identifier.emailNg, MH: hrmmnmh@hkucc.hku.hk-
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hk-
dc.identifier.authorityZheng, BJ=rp00353en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/01.aids.0000131382.15232.dcen_US
dc.identifier.pmid15280786-
dc.identifier.scopuseid_2-s2.0-4143116692en_US
dc.identifier.hkuros99125-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4143116692&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue12en_US
dc.identifier.spage1729en_US
dc.identifier.epage1732en_US
dc.identifier.isiWOS:000223475000016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhao, XY=7407577215en_US
dc.identifier.scopusauthoridLee, SS=7601394467en_US
dc.identifier.scopusauthoridWong, KH=7404758411en_US
dc.identifier.scopusauthoridChan, KCW=35097079800en_US
dc.identifier.scopusauthoridHe, ZM=35603357900en_US
dc.identifier.scopusauthoridMa, S=26028397100en_US
dc.identifier.scopusauthoridNg, F=7103125273en_US
dc.identifier.scopusauthoridChan, CCS=36984586600en_US
dc.identifier.scopusauthoridHo, T=20134358700en_US
dc.identifier.scopusauthoridNg, MH=7202076421en_US
dc.identifier.scopusauthoridZheng, BJ=7201780588en_US

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