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Article: Comparison of T-Spot.TB and tuberculin skin test among silicotic patients

TitleComparison of T-Spot.TB and tuberculin skin test among silicotic patients
Authors
KeywordsLatent tuberculosis infection
Silicosis
Smoking
Issue Date2008
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2008, v. 31 n. 2, p. 266-272 How to Cite?
AbstractIn the present study, T-Spot.TB and the tuberculin skin test (TST) were compared in the screening of latent tuberculosis infection among silicotic patients. A conditional probability model was used to compare the potential clinical utilities of T-Spot.TB and TST performed on 134 silicotic subjects from December 1, 2004 to January 31, 2007. Data from a historical cohort were also reanalysed for further comparison. Agreement with T-Spot.TB was best using a TST cut-off of 10 mm. Age ≥65 yrs independently predicted a tuberculin reaction <10 mm (odds ratio=3), but not a negative T-Spot.TB response. Lower measures of agreement were observed among current smokers and those aged ≥65 yrs. Tuberculin reaction size was well correlated with both early secretary antigenic target 6 and culture filtrate protein 10 spot counts, except among current smokers. Within the current estimates of sensitivity (88-95%) and specificity (86-99%) for T-Spot.TB, the positive likelihood ratio for T-Spot.TB test would be substantially higher (6.29-95.0 versus 1.65-1.94) and negative likelihood ratio substantially lower (0.05-0.14 versus 0.32-0.41) than the corresponding ratios for the tuberculin test. A low tuberculosis risk differential was similarly observed between tuberculin-negative and untreated tuberculin-positive subjects in the historical cohort. T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects. Copyright©ERS Journals Ltd 2008.
Persistent Identifierhttp://hdl.handle.net/10722/157509
ISSN
2014 Impact Factor: 7.636
2014 SCImago Journal Rankings: 2.855
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, CCen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorTam, CMen_HK
dc.contributor.authorLaw, WSen_HK
dc.contributor.authorWong, MYen_HK
dc.contributor.authorLeung, Men_HK
dc.contributor.authorTsui, Den_HK
dc.date.accessioned2012-08-08T08:50:41Z-
dc.date.available2012-08-08T08:50:41Z-
dc.date.issued2008en_HK
dc.identifier.citationEuropean Respiratory Journal, 2008, v. 31 n. 2, p. 266-272en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/157509-
dc.description.abstractIn the present study, T-Spot.TB and the tuberculin skin test (TST) were compared in the screening of latent tuberculosis infection among silicotic patients. A conditional probability model was used to compare the potential clinical utilities of T-Spot.TB and TST performed on 134 silicotic subjects from December 1, 2004 to January 31, 2007. Data from a historical cohort were also reanalysed for further comparison. Agreement with T-Spot.TB was best using a TST cut-off of 10 mm. Age ≥65 yrs independently predicted a tuberculin reaction <10 mm (odds ratio=3), but not a negative T-Spot.TB response. Lower measures of agreement were observed among current smokers and those aged ≥65 yrs. Tuberculin reaction size was well correlated with both early secretary antigenic target 6 and culture filtrate protein 10 spot counts, except among current smokers. Within the current estimates of sensitivity (88-95%) and specificity (86-99%) for T-Spot.TB, the positive likelihood ratio for T-Spot.TB test would be substantially higher (6.29-95.0 versus 1.65-1.94) and negative likelihood ratio substantially lower (0.05-0.14 versus 0.32-0.41) than the corresponding ratios for the tuberculin test. A low tuberculosis risk differential was similarly observed between tuberculin-negative and untreated tuberculin-positive subjects in the historical cohort. T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects. Copyright©ERS Journals Ltd 2008.en_HK
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectLatent tuberculosis infectionen_HK
dc.subjectSilicosisen_HK
dc.subjectSmokingen_HK
dc.titleComparison of T-Spot.TB and tuberculin skin test among silicotic patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailYam, WC: wcyam@hkucc.hku.hken_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailLeung, M:en_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityLeung, M=rp00148en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1183/09031936.00054707en_HK
dc.identifier.scopuseid_2-s2.0-40649086465en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40649086465&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue2en_HK
dc.identifier.spage266en_HK
dc.identifier.epage272en_HK
dc.identifier.isiWOS:000253038400009-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLeung, CC=7402612644en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridTam, CM=7201442997en_HK
dc.identifier.scopusauthoridLaw, WS=7103147875en_HK
dc.identifier.scopusauthoridWong, MY=26023969500en_HK
dc.identifier.scopusauthoridLeung, M=8862966600en_HK
dc.identifier.scopusauthoridTsui, D=35452031000en_HK

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