Article: Comparison of T-Spot.TB and tuberculin skin test among silicotic patients

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TitleComparison of T-Spot.TB and tuberculin skin test among silicotic patients
AuthorsLeung, CC1 3
Yam, WC2
Yew, WW4
Ho, PL2
Tam, CM3
Law, WS3
Wong, MY3
Leung, M3
Tsui, D3
KeywordsLatent tuberculosis infection
Silicosis
Smoking
Issue Date2008
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
CitationEuropean Respiratory Journal, 2008, v. 31 n. 2, p. 266-272 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.00054707
AbstractIn the present study, T-Spot.TB and the tuberculin skin test (TST) were compared in the screening of latent tuberculosis infection among silicotic patients. A conditional probability model was used to compare the potential clinical utilities of T-Spot.TB and TST performed on 134 silicotic subjects from December 1, 2004 to January 31, 2007. Data from a historical cohort were also reanalysed for further comparison. Agreement with T-Spot.TB was best using a TST cut-off of 10 mm. Age ≥65 yrs independently predicted a tuberculin reaction <10 mm (odds ratio=3), but not a negative T-Spot.TB response. Lower measures of agreement were observed among current smokers and those aged ≥65 yrs. Tuberculin reaction size was well correlated with both early secretary antigenic target 6 and culture filtrate protein 10 spot counts, except among current smokers. Within the current estimates of sensitivity (88-95%) and specificity (86-99%) for T-Spot.TB, the positive likelihood ratio for T-Spot.TB test would be substantially higher (6.29-95.0 versus 1.65-1.94) and negative likelihood ratio substantially lower (0.05-0.14 versus 0.32-0.41) than the corresponding ratios for the tuberculin test. A low tuberculosis risk differential was similarly observed between tuberculin-negative and untreated tuberculin-positive subjects in the historical cohort. T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects. Copyright©ERS Journals Ltd 2008.
ISSN0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
DOIhttp://dx.doi.org/10.1183/09031936.00054707
ISI Accession Number IDWOS:000253038400009
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLeung, CC
dc.contributor.authorYam, WC
dc.contributor.authorYew, WW
dc.contributor.authorHo, PL
dc.contributor.authorTam, CM
dc.contributor.authorLaw, WS
dc.contributor.authorWong, MY
dc.contributor.authorLeung, M
dc.contributor.authorTsui, D
dc.date.accessioned2012-08-08T08:50:41Z
dc.date.available2012-08-08T08:50:41Z
dc.date.issued2008
dc.description.abstractIn the present study, T-Spot.TB and the tuberculin skin test (TST) were compared in the screening of latent tuberculosis infection among silicotic patients. A conditional probability model was used to compare the potential clinical utilities of T-Spot.TB and TST performed on 134 silicotic subjects from December 1, 2004 to January 31, 2007. Data from a historical cohort were also reanalysed for further comparison. Agreement with T-Spot.TB was best using a TST cut-off of 10 mm. Age ≥65 yrs independently predicted a tuberculin reaction <10 mm (odds ratio=3), but not a negative T-Spot.TB response. Lower measures of agreement were observed among current smokers and those aged ≥65 yrs. Tuberculin reaction size was well correlated with both early secretary antigenic target 6 and culture filtrate protein 10 spot counts, except among current smokers. Within the current estimates of sensitivity (88-95%) and specificity (86-99%) for T-Spot.TB, the positive likelihood ratio for T-Spot.TB test would be substantially higher (6.29-95.0 versus 1.65-1.94) and negative likelihood ratio substantially lower (0.05-0.14 versus 0.32-0.41) than the corresponding ratios for the tuberculin test. A low tuberculosis risk differential was similarly observed between tuberculin-negative and untreated tuberculin-positive subjects in the historical cohort. T-Spot.TB is likely to perform better than tuberculin test in the screening of latent tuberculosis infection among silicotic subjects. Copyright©ERS Journals Ltd 2008.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Respiratory Journal, 2008, v. 31 n. 2, p. 266-272 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.00054707
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.00054707
dc.identifier.epage272
dc.identifier.isiWOS:000253038400009
dc.identifier.issn0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
dc.identifier.issue2
dc.identifier.scopuseid_2-s2.0-40649086465
dc.identifier.spage266
dc.identifier.urihttp://hdl.handle.net/10722/157509
dc.identifier.volume31
dc.languageeng
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
dc.publisher.placeSwitzerland
dc.relation.ispartofEuropean Respiratory Journal
dc.relation.referencesReferences in Scopus
dc.subjectLatent tuberculosis infection
dc.subjectSilicosis
dc.subjectSmoking
dc.titleComparison of T-Spot.TB and tuberculin skin test among silicotic patients
dc.typeArticle
Author Affiliations
  1. Pneumoconiosis Clinic
  2. The University of Hong Kong
  3. Centre for Health Protection
  4. Grantham Hospital Hong Kong