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Article: Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007

TitleAntigenic profile of avian H5N1 viruses in Asia from 2002 to 2007
Authors
Issue Date2008
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2008, v. 82 n. 4, p. 1798-1807 How to Cite?
AbstractAntigenic profiles of post-2002 H5N1 viruses representing major genetic clades and various geographic sources were investigated using a panel of 17 monoclonal antibodies raised from five H5N1 strains. Four antigenic groups from seven clades of H5N1 virus were distinguished and characterized based on their cross-reactivity to the monoclonal antibodies in hemagglutination inhibition and cell-based neutralization assays. Genetic polymorphisms associated with the variation of antigenicity of H5N1 strains were identified and further verified in antigenic analysis with recombinant H5N1 viruses carrying specific mutations in the hemagglutinin protein. Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera raised against clade 1 and 2 H5N1 viruses, suggesting that these sites represent antigenically significant amino acids. These results provide a comprehensive antigenic profile for H5N1 virus strains circulating in recent years and will facilitate the recognition of emerging antigenic variants of H5N1 virus and aid in the selection of vaccine strains. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157504
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, WLen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorSong, Wen_HK
dc.contributor.authorLau, SYen_HK
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorSmith, GJen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLin, Ten_HK
dc.contributor.authorXia, Nen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorChen, Hen_HK
dc.date.accessioned2012-08-08T08:50:39Z-
dc.date.available2012-08-08T08:50:39Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal of Virology, 2008, v. 82 n. 4, p. 1798-1807en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/157504-
dc.description.abstractAntigenic profiles of post-2002 H5N1 viruses representing major genetic clades and various geographic sources were investigated using a panel of 17 monoclonal antibodies raised from five H5N1 strains. Four antigenic groups from seven clades of H5N1 virus were distinguished and characterized based on their cross-reactivity to the monoclonal antibodies in hemagglutination inhibition and cell-based neutralization assays. Genetic polymorphisms associated with the variation of antigenicity of H5N1 strains were identified and further verified in antigenic analysis with recombinant H5N1 viruses carrying specific mutations in the hemagglutinin protein. Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera raised against clade 1 and 2 H5N1 viruses, suggesting that these sites represent antigenically significant amino acids. These results provide a comprehensive antigenic profile for H5N1 virus strains circulating in recent years and will facilitate the recognition of emerging antigenic variants of H5N1 virus and aid in the selection of vaccine strains. Copyright © 2008, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshAntigenic Variationen_US
dc.subject.meshAntigens, Viral - Classification - Genetics - Immunologyen_US
dc.subject.meshAsia - Epidemiologyen_US
dc.subject.meshBirdsen_US
dc.subject.meshCross Reactionsen_US
dc.subject.meshHemagglutinins, Viral - Classification - Genetics - Immunologyen_US
dc.subject.meshInfluenza A Virus, H5N1 Subtype - Genetics - Immunologyen_US
dc.subject.meshInfluenza Vaccines - Genetics - Immunologyen_US
dc.subject.meshInfluenza In Birds - Epidemiology - Virologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshProtein Conformationen_US
dc.titleAntigenic profile of avian H5N1 viruses in Asia from 2002 to 2007en_HK
dc.typeArticleen_HK
dc.identifier.emailWu, WL: hazelwu@hkucc.hku.hken_HK
dc.identifier.emailWang, P: puiwang@hkucc.hku.hken_HK
dc.identifier.emailSong, W: dbsswj@nus.edu.sgen_HK
dc.identifier.emailLau, SY: lausiuying@hotmail.comen_HK
dc.identifier.emailRayner, JM: raynerj2002@yahoo.com-
dc.identifier.emailSmith, GJ: gjsmith@hkucc.hku.hk-
dc.identifier.emailWebster, RG: stjude@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailLin, T: twlin@scripps.edu-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.authoritySmith, GJD=rp00444en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1128/JVI.02256-07en_HK
dc.identifier.pmid18077726-
dc.identifier.pmcidPMC2258718-
dc.identifier.scopuseid_2-s2.0-38949120565en_HK
dc.identifier.hkuros146122-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38949120565&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1798en_HK
dc.identifier.epage1807en_HK
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:000252909300016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWai, LW=23490386700en_HK
dc.identifier.scopusauthoridChen, Y=10739973700en_HK
dc.identifier.scopusauthoridWang, P=13907209900en_HK
dc.identifier.scopusauthoridSong, W=23490429800en_HK
dc.identifier.scopusauthoridLau, SY=35083705100en_HK
dc.identifier.scopusauthoridRayner, JM=12752258200en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLin, T=7404860987en_HK
dc.identifier.scopusauthoridXia, N=35187953700en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.citeulike2320259-
dc.customcontrol.immutablesml 130528-

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