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Article: Antimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
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TitleAntimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
 
AuthorsHo, PL4
Wong, RCW1
Yip, KS4
Loke, SL2
Leung, MST3
Mak, GC4
Chow, FKH4
Tsang, KWT4
Que, TL1
 
Issue Date2007
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
CitationDiagnostic Microbiology And Infectious Disease, 2007, v. 59 n. 4, p. 439-445 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
 
AbstractThis study evaluated the antimicrobial resistance profile of outpatient urinary Escherichia coli isolated from women obtained throughout Hong Kong during 2004-2005. Of 1067 single patient isolates analyzed, 60.1% were resistant to ampicillin, 34% were resistant to co-trimoxazole, and 22.1% were resistant to ciprofloxacin. Thirty-four (6.6%) of 519 isolates in 2004 and 55 (10%) of 548 isolates in 2005 were extended-spectrum β-lactamase (ESBL) producers with a CTX-M phenotype. Rates of non-β-lactam resistance and ESBL production were strongly influenced by patient age. The age-stratified rates for dual co-trimoxazole and ciprofloxacin resistance and for ESBL production were 10.9% and 7.6% in women aged 18-35 years, 13% and 6.9% in women aged 36-50 years, 20.4% and 8.8% in women aged 51-64 years, and 23.7% and 11.8% in women aged ≥65 years, respectively. Nitrofurantoin and fosfomycin remain active against >90% of the isolates, irrespective of the resistance phenotypes for other drugs. Our results documented the emergence of problematic resistance phenotypes among community urinary E. coli and highlight the need to explore strategies for their containment. © 2007 Elsevier Inc. All rights reserved.
 
ISSN0732-8893
2012 Impact Factor: 2.26
2012 SCImago Journal Rankings: 0.971
 
DOIhttp://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
 
ISI Accession Number IDWOS:000251809600014
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorWong, RCW
 
dc.contributor.authorYip, KS
 
dc.contributor.authorLoke, SL
 
dc.contributor.authorLeung, MST
 
dc.contributor.authorMak, GC
 
dc.contributor.authorChow, FKH
 
dc.contributor.authorTsang, KWT
 
dc.contributor.authorQue, TL
 
dc.date.accessioned2012-08-08T08:50:34Z
 
dc.date.available2012-08-08T08:50:34Z
 
dc.date.issued2007
 
dc.description.abstractThis study evaluated the antimicrobial resistance profile of outpatient urinary Escherichia coli isolated from women obtained throughout Hong Kong during 2004-2005. Of 1067 single patient isolates analyzed, 60.1% were resistant to ampicillin, 34% were resistant to co-trimoxazole, and 22.1% were resistant to ciprofloxacin. Thirty-four (6.6%) of 519 isolates in 2004 and 55 (10%) of 548 isolates in 2005 were extended-spectrum β-lactamase (ESBL) producers with a CTX-M phenotype. Rates of non-β-lactam resistance and ESBL production were strongly influenced by patient age. The age-stratified rates for dual co-trimoxazole and ciprofloxacin resistance and for ESBL production were 10.9% and 7.6% in women aged 18-35 years, 13% and 6.9% in women aged 36-50 years, 20.4% and 8.8% in women aged 51-64 years, and 23.7% and 11.8% in women aged ≥65 years, respectively. Nitrofurantoin and fosfomycin remain active against >90% of the isolates, irrespective of the resistance phenotypes for other drugs. Our results documented the emergence of problematic resistance phenotypes among community urinary E. coli and highlight the need to explore strategies for their containment. © 2007 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2007, v. 59 n. 4, p. 439-445 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
 
dc.identifier.epage445
 
dc.identifier.isiWOS:000251809600014
 
dc.identifier.issn0732-8893
2012 Impact Factor: 2.26
2012 SCImago Journal Rankings: 0.971
 
dc.identifier.issue4
 
dc.identifier.pmid17888610
 
dc.identifier.scopuseid_2-s2.0-36549006487
 
dc.identifier.spage439
 
dc.identifier.urihttp://hdl.handle.net/10722/157496
 
dc.identifier.volume59
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAnti-Bacterial Agents - Pharmacology
 
dc.subject.meshDrug Resistance, Multiple, Bacterial
 
dc.subject.meshEscherichia Coli - Drug Effects - Enzymology
 
dc.subject.meshEscherichia Coli Infections - Epidemiology - Microbiology
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshMicrobial Sensitivity Tests
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOutpatients
 
dc.subject.meshPhenotype
 
dc.subject.meshPopulation Surveillance
 
dc.subject.meshUrinary Tract Infections - Epidemiology - Microbiology
 
dc.subject.meshBeta-Lactamases - Biosynthesis
 
dc.titleAntimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
 
dc.typeArticle
 
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Author Affiliations
  1. Tuen Mun Hospital
  2. St. Teresa's Hospital
  3. null
  4. Centre of Infection