Article: Antimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes

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TitleAntimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
AuthorsHo, PL4
Wong, RCW1
Yip, KS4
Loke, SL2
Leung, MST3
Mak, GC4
Chow, FKH4
Tsang, KWT4
Que, TL1
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
CitationDiagnostic Microbiology And Infectious Disease, 2007, v. 59 n. 4, p. 439-445 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
AbstractThis study evaluated the antimicrobial resistance profile of outpatient urinary Escherichia coli isolated from women obtained throughout Hong Kong during 2004-2005. Of 1067 single patient isolates analyzed, 60.1% were resistant to ampicillin, 34% were resistant to co-trimoxazole, and 22.1% were resistant to ciprofloxacin. Thirty-four (6.6%) of 519 isolates in 2004 and 55 (10%) of 548 isolates in 2005 were extended-spectrum β-lactamase (ESBL) producers with a CTX-M phenotype. Rates of non-β-lactam resistance and ESBL production were strongly influenced by patient age. The age-stratified rates for dual co-trimoxazole and ciprofloxacin resistance and for ESBL production were 10.9% and 7.6% in women aged 18-35 years, 13% and 6.9% in women aged 36-50 years, 20.4% and 8.8% in women aged 51-64 years, and 23.7% and 11.8% in women aged ≥65 years, respectively. Nitrofurantoin and fosfomycin remain active against >90% of the isolates, irrespective of the resistance phenotypes for other drugs. Our results documented the emergence of problematic resistance phenotypes among community urinary E. coli and highlight the need to explore strategies for their containment. © 2007 Elsevier Inc. All rights reserved.
ISSN0732-8893
2011 Impact Factor: 2.528
2011 SCImago Journal Rankings: 0.210
DOIhttp://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
ISI Accession Number IDWOS:000251809600014
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, PL
dc.contributor.authorWong, RCW
dc.contributor.authorYip, KS
dc.contributor.authorLoke, SL
dc.contributor.authorLeung, MST
dc.contributor.authorMak, GC
dc.contributor.authorChow, FKH
dc.contributor.authorTsang, KWT
dc.contributor.authorQue, TL
dc.date.accessioned2012-08-08T08:50:34Z
dc.date.available2012-08-08T08:50:34Z
dc.date.issued2007
dc.description.abstractThis study evaluated the antimicrobial resistance profile of outpatient urinary Escherichia coli isolated from women obtained throughout Hong Kong during 2004-2005. Of 1067 single patient isolates analyzed, 60.1% were resistant to ampicillin, 34% were resistant to co-trimoxazole, and 22.1% were resistant to ciprofloxacin. Thirty-four (6.6%) of 519 isolates in 2004 and 55 (10%) of 548 isolates in 2005 were extended-spectrum β-lactamase (ESBL) producers with a CTX-M phenotype. Rates of non-β-lactam resistance and ESBL production were strongly influenced by patient age. The age-stratified rates for dual co-trimoxazole and ciprofloxacin resistance and for ESBL production were 10.9% and 7.6% in women aged 18-35 years, 13% and 6.9% in women aged 36-50 years, 20.4% and 8.8% in women aged 51-64 years, and 23.7% and 11.8% in women aged ≥65 years, respectively. Nitrofurantoin and fosfomycin remain active against >90% of the isolates, irrespective of the resistance phenotypes for other drugs. Our results documented the emergence of problematic resistance phenotypes among community urinary E. coli and highlight the need to explore strategies for their containment. © 2007 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2007, v. 59 n. 4, p. 439-445 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
dc.identifier.doihttp://dx.doi.org/10.1016/j.diagmicrobio.2007.06.012
dc.identifier.epage445
dc.identifier.isiWOS:000251809600014
dc.identifier.issn0732-8893
2011 Impact Factor: 2.528
2011 SCImago Journal Rankings: 0.210
dc.identifier.issue4
dc.identifier.pmid17888610
dc.identifier.scopuseid_2-s2.0-36549006487
dc.identifier.spage439
dc.identifier.urihttp://hdl.handle.net/10722/157496
dc.identifier.volume59
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
dc.publisher.placeUnited States
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnti-Bacterial Agents - Pharmacology
dc.subject.meshDrug Resistance, Multiple, Bacterial
dc.subject.meshEscherichia Coli - Drug Effects - Enzymology
dc.subject.meshEscherichia Coli Infections - Epidemiology - Microbiology
dc.subject.meshFemale
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMiddle Aged
dc.subject.meshOutpatients
dc.subject.meshPhenotype
dc.subject.meshPopulation Surveillance
dc.subject.meshUrinary Tract Infections - Epidemiology - Microbiology
dc.subject.meshBeta-Lactamases - Biosynthesis
dc.titleAntimicrobial resistance in Escherichia coli outpatient urinary isolates from women: emerging multidrug resistance phenotypes
dc.typeArticle
Author Affiliations
  1. Tuen Mun Hospital
  2. St. Teresa's Hospital
  3. null
  4. Centre of Infection