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Article: Establishment of influenza A virus (H6N1) in minor poultry species in southern China

TitleEstablishment of influenza A virus (H6N1) in minor poultry species in southern China
Authors
Issue Date2007
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2007, v. 81 n. 19, p. 10402-10412 How to Cite?
AbstractAn H6N1 virus, A/teal/Hong Kong/W312/97 (W312), was isolated during the "bird flu" incident in Hong Kong in 1997. Genetic analysis suggested that this virus might be the progenitor of the A/Hong Kong/156/97 (HK/97) H5N1 virus, as seven of eight gene segments of those viruses had a common source. Continuing surveillance in Hong Kong showed that a W312-like virus was prevalent in quail and pheasants in 1999; however, the further development of H6N1 viruses has not been investigated since 2001. Here we report influenza virus surveillance data collected in southern China from 2000 to 2005 that show that H6N1 viruses have become established and endemic in minor poultry species and replicate mainly in the respiratory tract. Phylogenetic analysis indicated that all H6N1 isolates had W312-like hemagglutinin and neuraminidase genes. However, reassortment of internal genes between different subtype virus lineages, including H5N1, H9N2, and other avian viruses, generated multiple novel H6N1 genotypes in different types of poultry. These novel H6N1/N2 viruses are double, triple, or even quadruple reassortants. Reassortment between a W312-like H6N1 virus and an A/quail/Hong Kong/G1/97 (HK/97)-like H9N2 virus simultaneously generated novel H6N2 subtype viruses that were persistent in poultry. Molecular analyses suggest that W312-like viruses may not be the precursors of HK/97 virus but reassortants from an HK/97-like virus and another unidentified H6 subtype virus. These results provide further evidence of the pivotal role of the live poultry market system of southern China in generating increased genetic diversity in influenza viruses in this region. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157489
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorDhanasekaran, Ven_HK
dc.contributor.authorSmith, GJen_HK
dc.contributor.authorFan, XHen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorBahl, Jen_HK
dc.contributor.authorDuan, Len_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorTai, Hen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2012-08-08T08:50:28Z-
dc.date.available2012-08-08T08:50:28Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal of Virology, 2007, v. 81 n. 19, p. 10402-10412en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/157489-
dc.description.abstractAn H6N1 virus, A/teal/Hong Kong/W312/97 (W312), was isolated during the "bird flu" incident in Hong Kong in 1997. Genetic analysis suggested that this virus might be the progenitor of the A/Hong Kong/156/97 (HK/97) H5N1 virus, as seven of eight gene segments of those viruses had a common source. Continuing surveillance in Hong Kong showed that a W312-like virus was prevalent in quail and pheasants in 1999; however, the further development of H6N1 viruses has not been investigated since 2001. Here we report influenza virus surveillance data collected in southern China from 2000 to 2005 that show that H6N1 viruses have become established and endemic in minor poultry species and replicate mainly in the respiratory tract. Phylogenetic analysis indicated that all H6N1 isolates had W312-like hemagglutinin and neuraminidase genes. However, reassortment of internal genes between different subtype virus lineages, including H5N1, H9N2, and other avian viruses, generated multiple novel H6N1 genotypes in different types of poultry. These novel H6N1/N2 viruses are double, triple, or even quadruple reassortants. Reassortment between a W312-like H6N1 virus and an A/quail/Hong Kong/G1/97 (HK/97)-like H9N2 virus simultaneously generated novel H6N2 subtype viruses that were persistent in poultry. Molecular analyses suggest that W312-like viruses may not be the precursors of HK/97 virus but reassortants from an HK/97-like virus and another unidentified H6 subtype virus. These results provide further evidence of the pivotal role of the live poultry market system of southern China in generating increased genetic diversity in influenza viruses in this region. Copyright © 2007, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Viral - Analysisen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshGenes, Viralen_US
dc.subject.meshGenotypeen_US
dc.subject.meshInfluenza A Virus - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshInfluenza In Birds - Epidemiology - Virologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPoultry - Virologyen_US
dc.subject.meshSerotypingen_US
dc.titleEstablishment of influenza A virus (H6N1) in minor poultry species in southern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailDhanasekaran, V: veejay.here@gmail.comen_HK
dc.identifier.emailSmith, GJ: gjsmith@hkucc.hku.hken_HK
dc.identifier.emailZhang, J: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailDuan, L: dlhku@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hk-
dc.identifier.authoritySmith, GJ=rp00444en_HK
dc.identifier.authorityZhang, J=rp00413en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1128/JVI.01157-07en_HK
dc.identifier.pmid17652385-
dc.identifier.scopuseid_2-s2.0-34648822384en_HK
dc.identifier.hkuros132177-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34648822384&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue19en_HK
dc.identifier.spage10402en_HK
dc.identifier.epage10412en_HK
dc.identifier.isiWOS:000249617400020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridVijaykrishna, D=12752817700en_HK
dc.identifier.scopusauthoridSmith, GJD=8344015800en_HK
dc.identifier.scopusauthoridFan, XH=35227217200en_HK
dc.identifier.scopusauthoridZhang, JX=12752135600en_HK
dc.identifier.scopusauthoridBahl, J=35308668200en_HK
dc.identifier.scopusauthoridDuan, L=7201932765en_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridTai, H=41162004200en_HK
dc.identifier.scopusauthoridWang, J=36078145500en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.customcontrol.immutablesml 130524-

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