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Article: Community emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women
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TitleCommunity emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women
 
AuthorsHo, PL1
Poon, WWN1
Loke, SL2
Leung, MST3
Chow, KH1
Wong, RCW1
Yip, KS1
Lai, EL1
Tsang, KWT1
 
Issue Date2007
 
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
 
CitationJournal Of Antimicrobial Chemotherapy, 2007, v. 60 n. 1, p. 140-144 [How to Cite?]
DOI: http://dx.doi.org/10.1093/jac/dkm144
 
AbstractObjectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged ≥65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
 
ISSN0305-7453
2012 Impact Factor: 5.338
2012 SCImago Journal Rankings: 1.814
 
DOIhttp://dx.doi.org/10.1093/jac/dkm144
 
ISI Accession Number IDWOS:000248180200020
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHo, PL
 
dc.contributor.authorPoon, WWN
 
dc.contributor.authorLoke, SL
 
dc.contributor.authorLeung, MST
 
dc.contributor.authorChow, KH
 
dc.contributor.authorWong, RCW
 
dc.contributor.authorYip, KS
 
dc.contributor.authorLai, EL
 
dc.contributor.authorTsang, KWT
 
dc.date.accessioned2012-08-08T08:50:27Z
 
dc.date.available2012-08-08T08:50:27Z
 
dc.date.issued2007
 
dc.description.abstractObjectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged ≥65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Antimicrobial Chemotherapy, 2007, v. 60 n. 1, p. 140-144 [How to Cite?]
DOI: http://dx.doi.org/10.1093/jac/dkm144
 
dc.identifier.doihttp://dx.doi.org/10.1093/jac/dkm144
 
dc.identifier.epage144
 
dc.identifier.hkuros136518
 
dc.identifier.isiWOS:000248180200020
 
dc.identifier.issn0305-7453
2012 Impact Factor: 5.338
2012 SCImago Journal Rankings: 1.814
 
dc.identifier.issue1
 
dc.identifier.pmid17496058
 
dc.identifier.scopuseid_2-s2.0-34447552522
 
dc.identifier.spage140
 
dc.identifier.urihttp://hdl.handle.net/10722/157486
 
dc.identifier.volume60
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Antimicrobial Chemotherapy
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Antimicrobial Chemotherapy. Copyright © Oxford University Press.
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshAnti-Bacterial Agents - Pharmacology
 
dc.subject.meshCommunity-Acquired Infections - Epidemiology - Microbiology
 
dc.subject.meshEscherichia Coli - Drug Effects - Enzymology - Genetics - Isolation & Purification
 
dc.subject.meshEscherichia Coli Infections - Epidemiology - Microbiology
 
dc.subject.meshEscherichia Coli Proteins - Genetics - Metabolism
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshMicrobial Sensitivity Tests
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPopulation Surveillance
 
dc.subject.meshUrinary Tract Infections - Epidemiology - Microbiology
 
dc.subject.meshUrine - Microbiology
 
dc.subject.meshBeta-Lactamases - Classification - Genetics - Metabolism
 
dc.titleCommunity emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women
 
dc.typeArticle
 
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<contributor.author>Poon, WWN</contributor.author>
<contributor.author>Loke, SL</contributor.author>
<contributor.author>Leung, MST</contributor.author>
<contributor.author>Chow, KH</contributor.author>
<contributor.author>Wong, RCW</contributor.author>
<contributor.author>Yip, KS</contributor.author>
<contributor.author>Lai, EL</contributor.author>
<contributor.author>Tsang, KWT</contributor.author>
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<description.abstract>Objectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged &#8805;65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. &#169; The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. St. Teresa's Hospital
  3. null