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Article: Community emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women

TitleCommunity emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women
Authors
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
Citation
Journal Of Antimicrobial Chemotherapy, 2007, v. 60 n. 1, p. 140-144 How to Cite?
AbstractObjectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged ≥65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/157486
ISSN
2014 Impact Factor: 5.313
2014 SCImago Journal Rankings: 1.983
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_US
dc.contributor.authorPoon, WWNen_US
dc.contributor.authorLoke, SLen_US
dc.contributor.authorLeung, MSTen_US
dc.contributor.authorChow, KHen_US
dc.contributor.authorWong, RCWen_US
dc.contributor.authorYip, KSen_US
dc.contributor.authorLai, ELen_US
dc.contributor.authorTsang, KWTen_US
dc.date.accessioned2012-08-08T08:50:27Z-
dc.date.available2012-08-08T08:50:27Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Antimicrobial Chemotherapy, 2007, v. 60 n. 1, p. 140-144en_US
dc.identifier.issn0305-7453en_US
dc.identifier.urihttp://hdl.handle.net/10722/157486-
dc.description.abstractObjectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged ≥65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/en_US
dc.relation.ispartofJournal of Antimicrobial Chemotherapyen_US
dc.rightsJournal of Antimicrobial Chemotherapy. Copyright © Oxford University Press.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnti-Bacterial Agents - Pharmacologyen_US
dc.subject.meshCommunity-Acquired Infections - Epidemiology - Microbiologyen_US
dc.subject.meshEscherichia Coli - Drug Effects - Enzymology - Genetics - Isolation & Purificationen_US
dc.subject.meshEscherichia Coli Infections - Epidemiology - Microbiologyen_US
dc.subject.meshEscherichia Coli Proteins - Genetics - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPopulation Surveillanceen_US
dc.subject.meshUrinary Tract Infections - Epidemiology - Microbiologyen_US
dc.subject.meshUrine - Microbiologyen_US
dc.subject.meshBeta-Lactamases - Classification - Genetics - Metabolismen_US
dc.titleCommunity emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from womenen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.emailChow, KH:khchowb@hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityChow, KH=rp00370en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/jac/dkm144en_US
dc.identifier.pmid17496058en_US
dc.identifier.scopuseid_2-s2.0-34447552522en_US
dc.identifier.hkuros136518-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447552522&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue1en_US
dc.identifier.spage140en_US
dc.identifier.epage144en_US
dc.identifier.isiWOS:000248180200020-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridPoon, WWN=34968449300en_US
dc.identifier.scopusauthoridLoke, SL=55228176700en_US
dc.identifier.scopusauthoridLeung, MST=36928968000en_US
dc.identifier.scopusauthoridChow, KH=7202180736en_US
dc.identifier.scopusauthoridWong, RCW=8612000100en_US
dc.identifier.scopusauthoridYip, KS=23020572500en_US
dc.identifier.scopusauthoridLai, EL=8238477100en_US
dc.identifier.scopusauthoridTsang, KWT=7201555024en_US

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