Article: Community emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women

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TitleCommunity emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women
AuthorsHo, PL1
Poon, WWN1
Loke, SL2
Leung, MST3
Chow, KH1
Wong, RCW1
Yip, KS1
Lai, EL1
Tsang, KWT1
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
CitationJournal Of Antimicrobial Chemotherapy, 2007, v. 60 n. 1, p. 140-144 [How to Cite?]
DOI: http://dx.doi.org/10.1093/jac/dkm144
AbstractObjectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged ≥65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
ISSN0305-7453
2011 Impact Factor: 5.068
2011 SCImago Journal Rankings: 0.422
DOIhttp://dx.doi.org/10.1093/jac/dkm144
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHo, PL
dc.contributor.authorPoon, WWN
dc.contributor.authorLoke, SL
dc.contributor.authorLeung, MST
dc.contributor.authorChow, KH
dc.contributor.authorWong, RCW
dc.contributor.authorYip, KS
dc.contributor.authorLai, EL
dc.contributor.authorTsang, KWT
dc.date.accessioned2012-08-08T08:50:27Z
dc.date.available2012-08-08T08:50:27Z
dc.date.issued2007
dc.description.abstractObjectives: To conduct a territory-wide study of extended-spectrum b-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong. Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs. Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18-35 years, 5% (11/219) for women aged 36-50 years, 6.3% (4/63) for women aged 51-64 years and 10.6% (12/113) for women aged ≥65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTXM- 15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non- ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P 5 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18-35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1). Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Antimicrobial Chemotherapy, 2007, v. 60 n. 1, p. 140-144 [How to Cite?]
DOI: http://dx.doi.org/10.1093/jac/dkm144
dc.identifier.doihttp://dx.doi.org/10.1093/jac/dkm144
dc.identifier.epage144
dc.identifier.hkuros136518
dc.identifier.isiWOS:000248180200020
dc.identifier.issn0305-7453
2011 Impact Factor: 5.068
2011 SCImago Journal Rankings: 0.422
dc.identifier.issue1
dc.identifier.pmid17496058
dc.identifier.scopuseid_2-s2.0-34447552522
dc.identifier.spage140
dc.identifier.urihttp://hdl.handle.net/10722/157486
dc.identifier.volume60
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Antimicrobial Chemotherapy
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Antimicrobial Chemotherapy. Copyright © Oxford University Press.
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 And Over
dc.subject.meshAnti-Bacterial Agents - Pharmacology
dc.subject.meshCommunity-Acquired Infections - Epidemiology - Microbiology
dc.subject.meshEscherichia Coli - Drug Effects - Enzymology - Genetics - Isolation & Purification
dc.subject.meshEscherichia Coli Infections - Epidemiology - Microbiology
dc.subject.meshEscherichia Coli Proteins - Genetics - Metabolism
dc.subject.meshFemale
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMiddle Aged
dc.subject.meshPopulation Surveillance
dc.subject.meshUrinary Tract Infections - Epidemiology - Microbiology
dc.subject.meshUrine - Microbiology
dc.subject.meshBeta-Lactamases - Classification - Genetics - Metabolism
dc.titleCommunity emergence of CTX-M type extended-spectrum β-lactamases among urinary Escherichia coli from women
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. St. Teresa's Hospital
  3. null