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Article: Catabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada
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TitleCatabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada
 
AuthorsLau, SKP1
Mcnabb, A3
Woo, GKS1
Hoang, L2 3
Fung, AMY1
Chung, LMW1
Woo, PCY1
Yuen, KY1
 
Issue Date2007
 
CitationJournal Of Clinical Microbiology, 2007, v. 45 n. 2, p. 395-401 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.01831-06
 
AbstractFour bacterial isolates were recovered from the blood cultures of four patients, two of whom were from Hong Kong and two of whom were from Canada. The two Hong Kong strains were isolated from a 48-year-old man with intestinal obstruction and secondary sepsis (strain HKU16T) and from a 39-year-old man with acute appendicitis (strain HKU17), while the two Canadian strains were isolated from a 74-year-old man with biliary sepsis (strain CA1) and from a 66-year-old woman with metastatic carcinoma and sepsis (strain CA2). While the first three patients survived, the last patient died 2 weeks after the episode of bacteremia. All four isolates are strictly anaerobic, nonsporulating, gram-positive coccobacilli that were unidentified by conventional phenotypic tests and commercial identification systems. They grow on sheep blood agar as nonhemolytic pinpoint colonies after 48 h of incubation at 37°C in an anaerobic environment. All are catalase positive and motile, with flagella. They produce acid from arabinose, glucose, mannose, and xylose. They do not produce indole or reduce nitrate. They are sensitive to penicillin, vancomycin, and metronidazole but resistant to cefotaxime. 16S rRNA gene sequence analysis showed 16.0%, 16.8%, and 21.0% base differences from Clostridium propionicum, Clostridium neopropionicum, and Atopobium minutum, respectively. The G+C content of strain HKU16T is 40.2% ± 2.2%. Based on their phylogenetic affiliation, unique G+C content, and phenotypic characteristics, we propose a new genus and species, Catabacter hongkongensis gen. nov., sp. nov., to describe the bacterium, for which HKU16 is the type strain, and suggest that it be assigned to a new family, Catabacteriaceae. The gastrointestinal tract was probably the source of the bacterium for at least three of the four patients. The isolation of a catalase-positive, motile, nonsporulating, anaerobic gram-positive bacillus in clinical laboratories should raise the possibility of C. hongkongensis. Further studies should be performed to ascertain the epidemiology and other disease associations of this bacterium. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
 
ISSN0095-1137
2012 Impact Factor: 4.068
2012 SCImago Journal Rankings: 1.785
 
DOIhttp://dx.doi.org/10.1128/JCM.01831-06
 
ISI Accession Number IDWOS:000244270000022
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLau, SKP
 
dc.contributor.authorMcnabb, A
 
dc.contributor.authorWoo, GKS
 
dc.contributor.authorHoang, L
 
dc.contributor.authorFung, AMY
 
dc.contributor.authorChung, LMW
 
dc.contributor.authorWoo, PCY
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2012-08-08T08:50:15Z
 
dc.date.available2012-08-08T08:50:15Z
 
dc.date.issued2007
 
dc.description.abstractFour bacterial isolates were recovered from the blood cultures of four patients, two of whom were from Hong Kong and two of whom were from Canada. The two Hong Kong strains were isolated from a 48-year-old man with intestinal obstruction and secondary sepsis (strain HKU16T) and from a 39-year-old man with acute appendicitis (strain HKU17), while the two Canadian strains were isolated from a 74-year-old man with biliary sepsis (strain CA1) and from a 66-year-old woman with metastatic carcinoma and sepsis (strain CA2). While the first three patients survived, the last patient died 2 weeks after the episode of bacteremia. All four isolates are strictly anaerobic, nonsporulating, gram-positive coccobacilli that were unidentified by conventional phenotypic tests and commercial identification systems. They grow on sheep blood agar as nonhemolytic pinpoint colonies after 48 h of incubation at 37°C in an anaerobic environment. All are catalase positive and motile, with flagella. They produce acid from arabinose, glucose, mannose, and xylose. They do not produce indole or reduce nitrate. They are sensitive to penicillin, vancomycin, and metronidazole but resistant to cefotaxime. 16S rRNA gene sequence analysis showed 16.0%, 16.8%, and 21.0% base differences from Clostridium propionicum, Clostridium neopropionicum, and Atopobium minutum, respectively. The G+C content of strain HKU16T is 40.2% ± 2.2%. Based on their phylogenetic affiliation, unique G+C content, and phenotypic characteristics, we propose a new genus and species, Catabacter hongkongensis gen. nov., sp. nov., to describe the bacterium, for which HKU16 is the type strain, and suggest that it be assigned to a new family, Catabacteriaceae. The gastrointestinal tract was probably the source of the bacterium for at least three of the four patients. The isolation of a catalase-positive, motile, nonsporulating, anaerobic gram-positive bacillus in clinical laboratories should raise the possibility of C. hongkongensis. Further studies should be performed to ascertain the epidemiology and other disease associations of this bacterium. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Clinical Microbiology, 2007, v. 45 n. 2, p. 395-401 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.01831-06
 
dc.identifier.doihttp://dx.doi.org/10.1128/JCM.01831-06
 
dc.identifier.epage401
 
dc.identifier.hkuros127781
 
dc.identifier.isiWOS:000244270000022
 
dc.identifier.issn0095-1137
2012 Impact Factor: 4.068
2012 SCImago Journal Rankings: 1.785
 
dc.identifier.issue2
 
dc.identifier.pmid17122022
 
dc.identifier.scopuseid_2-s2.0-33847022234
 
dc.identifier.spage395
 
dc.identifier.urihttp://hdl.handle.net/10722/157472
 
dc.identifier.volume45
 
dc.languageeng
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Microbiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAnaerobiosis
 
dc.subject.meshBacteremia - Epidemiology - Microbiology
 
dc.subject.meshBacterial Typing Techniques
 
dc.subject.meshBase Composition
 
dc.subject.meshBlood - Microbiology
 
dc.subject.meshCanada - Epidemiology
 
dc.subject.meshCulture Media
 
dc.subject.meshFemale
 
dc.subject.meshGram-Positive Bacteria - Classification - Genetics - Isolation & Purification
 
dc.subject.meshGram-Positive Bacterial Infections - Epidemiology - Microbiology
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshPhenotype
 
dc.subject.meshPhylogeny
 
dc.subject.meshRna, Ribosomal, 16S - Genetics
 
dc.subject.meshSequence Analysis, Dna
 
dc.titleCatabacter hongkongensis gen. nov., sp. nov., isolated from blood cultures of patients from Hong Kong and Canada
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. The University of British Columbia
  3. BC Centre for Disease Control