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Article: Using β-lactamase to trigger supramolecular hydrogelation

TitleUsing β-lactamase to trigger supramolecular hydrogelation
Authors
Issue Date2007
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html
Citation
Journal of the American Chemical Society, 2007, v. 129 n. 2, p. 266-267 How to Cite?
AbstractThis paper reports the rational design and synthesis of a β-lactam conjugate. Treating the conjugate with β-lactamase cleaves the scissile β-lactam amide bond, releases a hydrogelator, and results in enzymatic formation of a supramolecular hydrogel. The process involves the use of a bacterial enzymethe one causes antibiotic inactivation and accounts for resistance to β-lactams in many clinical important pathogensto catalyze the formation of the hydrogel. It offers an opportunity to investigate the kinetics of these types of enzymatic reactions, screen inhibitors of the enzyme, and provides a new candidate to generate hydrogels for biomedical applications. Copyright © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/157469
ISSN
2015 Impact Factor: 13.038
2015 SCImago Journal Rankings: 7.123
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Zen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorLiang, Gen_US
dc.contributor.authorChow, KHen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorCao, Yen_US
dc.contributor.authorGuo, Zen_US
dc.contributor.authorXu, Ben_US
dc.date.accessioned2012-08-08T08:50:13Z-
dc.date.available2012-08-08T08:50:13Z-
dc.date.issued2007en_US
dc.identifier.citationJournal of the American Chemical Society, 2007, v. 129 n. 2, p. 266-267en_US
dc.identifier.issn0002-7863en_US
dc.identifier.urihttp://hdl.handle.net/10722/157469-
dc.description.abstractThis paper reports the rational design and synthesis of a β-lactam conjugate. Treating the conjugate with β-lactamase cleaves the scissile β-lactam amide bond, releases a hydrogelator, and results in enzymatic formation of a supramolecular hydrogel. The process involves the use of a bacterial enzymethe one causes antibiotic inactivation and accounts for resistance to β-lactams in many clinical important pathogensto catalyze the formation of the hydrogel. It offers an opportunity to investigate the kinetics of these types of enzymatic reactions, screen inhibitors of the enzyme, and provides a new candidate to generate hydrogels for biomedical applications. Copyright © 2006 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.htmlen_US
dc.relation.ispartofJournal of the American Chemical Societyen_US
dc.subject.meshCatalysisen_US
dc.subject.meshHydrogel - Chemical Synthesis - Chemistryen_US
dc.subject.meshMacromolecular Substances - Chemical Synthesis - Chemistryen_US
dc.subject.meshMolecular Conformationen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshBeta-Lactamases - Chemistryen_US
dc.titleUsing β-lactamase to trigger supramolecular hydrogelationen_US
dc.typeArticleen_US
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_US
dc.identifier.emailChow, KH: khchowb@hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityChow, KH=rp00370en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1021/ja0675604en_US
dc.identifier.pmid17212393-
dc.identifier.scopuseid_2-s2.0-33846206093en_US
dc.identifier.hkuros125896-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846206093&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume129en_US
dc.identifier.issue2en_US
dc.identifier.spage266en_US
dc.identifier.epage267en_US
dc.identifier.isiWOS:000243381200012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYang, Z=7405429759en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridLiang, G=12244977600en_US
dc.identifier.scopusauthoridChow, KH=7202180736en_US
dc.identifier.scopusauthoridWang, Q=36475873200en_US
dc.identifier.scopusauthoridCao, Y=7404524308en_US
dc.identifier.scopusauthoridGuo, Z=7404658303en_US
dc.identifier.scopusauthoridXu, B=24752310700en_US
dc.customcontrol.immutablesml 130524-

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