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Article: Combining fluorescent probes and biofunctional magnetic nanoparticles for rapid detection of bacteria in human blood

TitleCombining fluorescent probes and biofunctional magnetic nanoparticles for rapid detection of bacteria in human blood
Authors
Issue Date2006
Citation
Advanced Materials, 2006, v. 18 n. 23, p. 3145-3148 How to Cite?
AbstractAn ultrasensitive procedure to detect bacteria in human blood or blood products using biofunctional magnetic nanoparticles in combination with a fluorescent probe is described. The presence of bacteria in blood components, particularly in the platelets are required to be monitored. The rate of bacterial contamination increases with the duration of storage of the platelet, as it has to be stored in room temperature. Magnetic nanoparticles were used as the platform for introducing Vancomycin (Van) to generate multivalent interactions, and capture the bacteria from the blood samples. This protocol allowed the detection of bacteria from the samples within two hours and had low sensitivity. The combination of magnetic manipulation and fluorescence eliminates the requirement for expensive or complicated instruments and allows implementation on a portable or hand-held device.
Persistent Identifierhttp://hdl.handle.net/10722/157467
ISSN
2015 Impact Factor: 18.96
2015 SCImago Journal Rankings: 9.021
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGao, Jen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorMak, GCen_US
dc.contributor.authorGu, Hen_US
dc.contributor.authorXu, Ben_US
dc.date.accessioned2012-08-08T08:50:12Z-
dc.date.available2012-08-08T08:50:12Z-
dc.date.issued2006en_US
dc.identifier.citationAdvanced Materials, 2006, v. 18 n. 23, p. 3145-3148en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttp://hdl.handle.net/10722/157467-
dc.description.abstractAn ultrasensitive procedure to detect bacteria in human blood or blood products using biofunctional magnetic nanoparticles in combination with a fluorescent probe is described. The presence of bacteria in blood components, particularly in the platelets are required to be monitored. The rate of bacterial contamination increases with the duration of storage of the platelet, as it has to be stored in room temperature. Magnetic nanoparticles were used as the platform for introducing Vancomycin (Van) to generate multivalent interactions, and capture the bacteria from the blood samples. This protocol allowed the detection of bacteria from the samples within two hours and had low sensitivity. The combination of magnetic manipulation and fluorescence eliminates the requirement for expensive or complicated instruments and allows implementation on a portable or hand-held device.en_US
dc.languageengen_US
dc.relation.ispartofAdvanced Materialsen_US
dc.titleCombining fluorescent probes and biofunctional magnetic nanoparticles for rapid detection of bacteria in human blooden_US
dc.typeArticleen_US
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_US
dc.identifier.authorityHo, PL=rp00406en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/adma.200601058en_US
dc.identifier.scopuseid_2-s2.0-33846146340en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846146340&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue23en_US
dc.identifier.spage3145en_US
dc.identifier.epage3148en_US
dc.identifier.isiWOS:000243183700015-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridGao, J=35487458900en_US
dc.identifier.scopusauthoridLi, H=36076816800en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridMak, GC=8883252800en_US
dc.identifier.scopusauthoridGu, H=7402683197en_US
dc.identifier.scopusauthoridXu, B=24752310700en_US

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